Chronic sleep disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in adolescent female mice

Murack, Michael; Chandrasegaram, Rajini; Smith, Kevin B.; Ah-Yen, Emily G.; Rheaume, E.; Malette-Guyon, Étienne; Nanji, Zahra; Semchishen, Seana; Latus, Olivia; Messier, Claude; Ismail, Nafissa

doi:10.1016/j.bbr.2020.113001

Cited by 32 publications

(18 citation statements)

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“…The average age of the patient group was (43.5 ± 5.2) years, which was also in line with the higher incidence of depression and menopause [ 50 , 51 ]. This may be because females show greater activation of the HPA axis than males, and the loss of estrogen during menopause shows the greatest HPA axis dysregulation [ 52 , 53 ]. The distribution of HAMD-24 scores in the control group ranged from 0 to 7, and none of them had depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

et al. 2022

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Background: Saliva cortisol is considered to be a biomarker of depression prediction. However, saliva collection methods can affect the saliva cortisol level. Objective: This study aims to determine the ideal saliva collection method and explore the application value of saliva cortisol in depression prediction. Methods: 30 depressed patients and 30 healthy controls were instructed to collect saliva samples in the morning with six collection methods. Simultaneous venous blood was collected. Enzyme-linked immunosorbent assay was used to determine the cortisol level. The 24-observerrated Hamilton depression rating scale (HAMD-24) was used to assess the severity of depression. Results: The significant differences in saliva cortisol levels depend on the saliva collection methods. The level of unstimulated whole saliva cortisol was most correlated with blood (r = 0.91). The stimulated parotid saliva cortisol can better predict depression. The area under the curve was 0.89. In addition, the saliva cortisol level of the depression patients was significantly higher than the healthy controls. The correlation between the cortisol level and the HAMD-24 score was highly significant. The higher the saliva cortisol level, the higher the HAMD-24 score. Conclusions: All the above findings point to an exciting opportunity for non-invasive monitoring of cortisol through saliva.

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Section: Discussionmentioning

confidence: 99%

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

et al. 2022

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“…Gentle handling 4 h at beginning of light phase from P42-50 but not P70-78 lead to increased immobility duration and reduced latency to immobility in the forced swim task on the last day of the protocol in both males and females ( Murack et al, 2021 ). Interestingly, corticosterone was increased in females, but not males after 30 min of restraint the day after the end of both gentle handling protocols.…”

Section: Behavioral Consequences Of Developmental Sleep Disruptionmentioning

confidence: 99%

“…An animal's cage includes its light source, the developmental chronic circadian disruption (DCCD) paradigm mimics severe shift-work with the light cycle advances dramatically every other or every fourth day ( Smarr et al, 2017 ; Ameen et al, 2022 ). Animal manipulation involves either gentle handling ( Medina et al, 2022 ; Weisman et al, 2011 ; Saré et al, 2016 , 2019 , 2022a ; Araujo et al, 2018 ; Yang et al, 2012 ; Murack et al, 2021 ) when the animal enters a sleep state, placing the animal on a platform over water where they are required to stay awake to avoid falling into the water ( da Silva Rocha-Lopes et al, 2018 ; Shaffery et al, 2006 ; Shaffery et al, 2002 ; Chen et al, 2015 ), or installing a sweeping bar that moves through the cage to enforce wakefulness ( Wallace et al, 2015 ; Atrooz et al, 2019 ). Pharmacological manipulation involves administration of a drug (e.g.…”

Section: Introduction: Function Of Normal Sleep In Developmentmentioning

confidence: 99%

Loss of sleep when it is needed most – Consequences of persistent developmental sleep disruption: A scoping review of rodent models

Milman

Tinsley

Raju

et al. 2023

Neurobiology of Sleep and Circadian Rhythms

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“…It was shown that chronic sleep disruption induces depression-like behavior in both adolescent male and female mice [ 30 ]. However, at the same time, it is well known that sleep deprivation has an antidepressant effect in patients with depression [ 31 , 32 , 33 ], alleviating depressive symptoms in 60% of them [ 34 , 35 ].…”

Section: Chronic Sleep Deprivationmentioning

confidence: 99%

Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables

Markov

Новосадова

2022

Biology

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Major depressive disorder (MDD) is one of the most common mood disorders worldwide. A lack of understanding of the exact neurobiological mechanisms of depression complicates the search for new effective drugs. Animal models are an important tool in the search for new approaches to the treatment of this disorder. All animal models of depression have certain advantages and disadvantages. We often hear that the main drawback of the chronic unpredictable mild stress (CUMS) model of depression is its poor reproducibility, but rarely does anyone try to find the real causes and sources of such poor reproducibility. Analyzing the articles available in the PubMed database, we tried to identify the factors that may be the sources of the poor reproducibility of CUMS. Among such factors, there may be chronic sleep deprivation, painful stressors, social stress, the difference in sex and age of animals, different stress susceptibility of different animal strains, handling quality, habituation to stressful factors, various combinations of physical and psychological stressors in the CUMS protocol, the influence of olfactory and auditory stimuli on animals, as well as the possible influence of various other factors that are rarely taken into account by researchers. We assume that careful inspection of these factors will increase the reproducibility of the CUMS model between laboratories and allow to make the interpretation of the obtained results and their comparison between laboratories to be more adequate.

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Chronic sleep disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in adolescent female mice

Cited by 32 publications

References 66 publications

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

Loss of sleep when it is needed most – Consequences of persistent developmental sleep disruption: A scoping review of rodent models

Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables

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