Chronic sleep restriction during development can lead to long-lasting behavioral effects

Saré, Rachel Michelle; Levine, Merlin; Hildreth, Christine; Picchioni, Dante; Smith, Carolyn Beebe

doi:10.1016/j.physbeh.2015.12.019

Cited by 40 publications

(52 citation statements)

References 27 publications

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“…2 This figure represents grounds for concern as sleep plays a key role in brain development and plasticity. 3 In addition, children affected by this difficulty often present associations with neurobehavioral disorders and a risk to mental health indicators. 4,5 Moreover, studies have shown that organized physical activity (PA) and cardiorespiratory fitness (CRF) are also associated with mental health.…”

Section: Introductionmentioning

confidence: 99%

Sleep and Childhood Mental Health: Role of Physical Activity and Cardiorespiratory Fitness

Fochesatto

Gaya

Brand

et al. 2020

Rev Bras Med Esporte

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Introduction: Sleep is considered an important health indicator and plays a key role in brain development and plasticity. Objective: To ascertain whether there is a relationship between sleep quality and mental health indicators and whether organized physical activity (PA) or cardiorespiratory fitness (CRF) act as moderators of this association. Methods: This is a cross-sectional study with a quantitative approach. The sample consisted of 226 students between six and 11 years of age, male and female, in the early years of elementary education at a public school in Porto Alegre, Brazil, which was selected for convenience. CRF was measured by running test and six-minute walk. Sleep quality and organized physical activity outside of school were verified through an anamnesis, socioeconomic status through an adaptation of the ABEP (Brazilian Association of Research Companies) questionnaire, and mental health indicators with the assistance of the Strengths and Difficulties Questionnaire, all answered by parents. Frequencies, means, standard deviations and generalized linear models were used for the data analysis, while a 95% confidence interval was used for the analyses. Results: Sleep quality was associated with total difficulties (β=7.659, p<0.001), emotional symptoms (β= 1.754; p=0.001), hyperactivity/inattentiveness (β=3.054, p <0.001), conduct problems (β=1.619, p<0.001) and peer relationship problems (β=1.231; p=0.007) in boys. In girls it was related to total difficulties (β=3.421; p=0.006), and conduct problems (β=1.235; p=0.003). However, the interactions were not significant. Conclusion: Although they occur independently, stress is placed on the importance of sleeping well, engaging in organized PA and having good CRF levels for the improvement and maintenance of mental health. Level of evidence III; Case-control study.

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Section: Introductionmentioning

confidence: 99%

Sleep and Childhood Mental Health: Role of Physical Activity and Cardiorespiratory Fitness

Fochesatto

Gaya

Brand

et al. 2020

Rev Bras Med Esporte

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“…2A and 2B), suggesting that distinct neural circuits underlie the shaping of these behavioral preferences and are vulnerable to sleep interventions at distinct developmental stages. More interestingly, both sleep manipulations, regardless in early childhood (Sare et al, 2016;Sare et al, 2019) or during adolescence (Fig. 3A and 3B), resulted to long-lasting behavioral changes in social interactions, highlighting the idea that sleep helps to shape the neural network underlying social behavior when it is still plastic during development, and the effects become "fixed" as the neural network matures in adulthood.…”

Section: Discussion: a Critical Period For Shaping The Neural Networkmentioning

confidence: 90%

“…Adolescence, on the other hand, provides an ideal time window that sleep monitoring and manipulations are feasible and the adolescent brain still undergoes substantial developmental changes such as synapse remodeling and circuit refinement (Bhatt et al, 2009;Bian et al, 2015;Moyer and Zuo, 2018). A study using chronic sleep restriction during the early postnatal stage in mice (P5 -P42) showed that it induced a series of longlasting behavioral changes 4 weeks after the completion of sleep restriction, including hypoactvity in both sexes, slightly increased sociality and social novelty preference in female mice but not in male mice, and female-specific decrease of marble burying behavior (Sare et al, 2016). However, a most recent follow-up study from the same lab showed that the same postnatal sleep restriction in male mice indeed led to changes of social interaction behaviors, with sociality increased but social novelty preference impaired (Sare et al, 2019).…”

Section: Discussion: a Critical Period For Shaping The Neural Networkmentioning

confidence: 99%

Adolescent sleep is critical for the developmental shaping of social novelty preference

Bian¹,

Lecea²

2020

Preprint

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AbstractSleep takes one-third of our lives, yet its functions remain largely unknown. A large proportion of young patients with neurodevelopmental disorders such as autism spectrum disorders (ASDs) and schizophrenia have sleep problems, including delayed sleep onset, shortened sleep duration and sleep fragmentation, which have been linked to social interaction deficit, a shared symptom of these disorders. However, the causal relationship between sleep disruption and social defects as well as the underlying mechanisms have not yet been established despite its importance in understanding the etiology of these disorders and developing potential therapeutic means. Here using the three-chamber social interaction test, we found that developmental sleep disruption (SD) in adolescent mice caused significant and long-lasting impairment in the preference towards social novelty during adult social interactions without affecting the overall sociality. Interestingly, SD performed in the adulthood did not induce any social defect, indicating a critical period within adolescence during which sleep shapes social novelty preference. Furthermore, by analyzing the adolescent sleep and adult social behavior in a mouse model of Shank3 mutation that mimics a genetic aberrance in ASDs, we found that the development of sociality is correlated with adolescent NREM sleep while social novelty preference is correlated with adolescent REM sleep. Collectively, these results demonstrate a critical role of adolescent sleep in the forming of social novelty preference and the developmental shaping of social behavior.

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“…Their study provides the present study with foundational evidence of memory deficits as a result of adolescent CSR. Their findings speak to the vulnerability of the adolescent brain, as do a number of other studies in which sleep disturbances in adolescence show immediate and, in some cases, long-lasting changes(Billeh et al, 2016; Novati et al, 2011;Saré et al, 2016;Ribeiro-Silva et al, 2016). The demonstrated vulnerability of the adolescent brain to sleep deficiency and the gap in research on resulting cognitive…”

mentioning

confidence: 76%

“…The same rats also underwent testing four weeks later at PND 67 and 70 in an attempt to investigate not only immediate effects of CSR in adolescence, but also if adolescent CSR effects on cognition persist into adulthood. The four-week delay is a dependable timeframe for examining the long-lasting effects to adulthood of an adolescent manipulation as PND 65 coincides with adulthood in the rat (Saré et al, 2016;Billeh et al, 2016;Spear, 2015).…”

Section: Purpose Of the Present Studymentioning

confidence: 99%

Immediate and long-lasting cognitive consequences of adolescent chronic sleep restriction.

Howard¹,

Hunter²

2019

Behavioral Neuroscience

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Adolescence is a critical developmental period. An important change that occurs in adolescence is the neurological maturation for adult-type cognitive abilities. Research has linked adequate sleep quantity to successful learning and memory capabilities. However, due to a shift in sleep timing drive in adolescence, in combination with early awakening for school, the adolescent population is experiencing chronic sleep restriction (CSR). What repercussions to long-term memory capabilities could CSR in adolescence have immediately and are the consequences longlasting? The present study modeled human adolescent CSR in rats through four hours of sleep deprivation for five days, followed by two days of unrestricted sleep, and five more days of four hours of sleep deprivation; thus the rats were exposed to CSR throughout the two-week rat adolescent period. Long-term hippocampal dependent and non-hippocampal dependent memory were tested through the object location task and the object recognition task, respectively. Testing occurred in adolescence and after a four-week delay during which the rats slept freely and matured to adulthood. The results showed that, given the appropriate conditions for successful long-term memory, the rats exposed to CSR in adolescence showed impaired hippocampal dependent memory in adolescence and this impairment was also evident in adulthood. These findings were not the case for non-hippocampal dependent memory, for which a significant effect of sleep was not found. Given the findings of the hippocampal dependent task, these results suggest that CSR in adolescence may influence less than optimal memory performance among adolescents. Further, the pattern in adulthood suggests that even after undisturbed sleep in the period from adolescence to adult maturation, the consequences of adolescent CSR are relentless. The findings in this study inform the research as the first rodent model of adolescent CSR and indicate practical implications for the health of adolescents.

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Chronic sleep restriction during development can lead to long-lasting behavioral effects

Cited by 40 publications

References 27 publications

Sleep and Childhood Mental Health: Role of Physical Activity and Cardiorespiratory Fitness

Sleep and Childhood Mental Health: Role of Physical Activity and Cardiorespiratory Fitness

Adolescent sleep is critical for the developmental shaping of social novelty preference

Immediate and long-lasting cognitive consequences of adolescent chronic sleep restriction.

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