Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis

Vegas, Oscar; Poligone, Brian; Blackcloud, Paul; Gilmore, Elaine S.; VanBuskirk, JoAnne; Ritchlin, Christopher T.; Pentland, Alice P.; Walter, Scott; Nousari, Yasmine; Tausk, Francisco

doi:10.1016/j.bbi.2017.10.022

Cited by 22 publications

(13 citation statements)

References 83 publications

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“…Moreover, SLURP-1 was found to antagonize biological functions attributed to Chrna7 in patients with pancreatic cancer ( 95 ) or malignant melanoma ( 96 ). In skin plagued by an inflammatory disease this pro-inflammatory effect could hence have deleterious effects and worsen inflammation, while it could protect from cancer progression and potentially viral infections in other contexts ( 33 , 41 , 97 ).…”

Section: Discussionmentioning

confidence: 99%

New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice

et al. 2021

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Background: The alpha7 nicotinic acetylcholine receptor (Chrna7) plays an essential anti-inflammatory role in immune homeostasis and was recently found on mast cells (MC). Psychosocial stress can trigger MC hyperactivation and increases pro-inflammatory cytokines in target tissues such as the skin. If the cholinergic system (CS) and Chrna7 ligands play a role in these cascades is largely unknown.Objective: To elucidate the role of the CS in the response to psychosocial stress using a mouse-model for stress-triggered cutaneous inflammatory circuits.Methods: Key CS markers (ACh, Ch, SLURP-1, SLURP-2, Lynx1, Chrm3, Chrna7, Chrna9, ChAT, VAChT, Oct3, AChE, and BChE) in skin and its MC (sMC), MC activation, immune parameters (TNFα, IL1β, IL10, TGFβ, HIF1α, and STAT3) and oxidative stress were analyzed in skin from 24 h noise-stressed mice and in cultured MC (cMC) from C57BL/6 or Chrna7-Knockout mice.Results: First, Chrna7 and SLURP-1 mRNA were exclusively upregulated in stressed skin. Second, histomorphometry located Chrna7 and SLURP-1 in nerves and sMC and demonstrated upregulated contacts and increased Chrna7+ sMC in stressed skin, while 5 ng/mL SLURP-1 degranulated cMC. Third, IL1β+ sMC were high in stressed skin, and while SLURP-1 alone had no significant effect on cMC cytokines, it upregulated IL1β in cMC from Chrna7-KO and in IL1β-treated wildtype cMC. In addition, HIF1α+ sMC were high in stressed skin and Chrna7-agonist AR-R 17779 induced ROS in cMC while SLURP-1 upregulated TNFα and IL1β in cMC when HIF1α was blocked.Conclusions: These data infer that the CS plays a role in the regulation of stress-sensitive inflammatory responses but may have a surprising pro-inflammatory effect in healthy skin, driving IL1β expression if SLURP-1 is involved.

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Section: Discussionmentioning

confidence: 99%

New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice

et al. 2021

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“…Recently, a hypothesis of the gut-brain-skin axis is being developed [68]. It has been proved that various skin disorders (urticarial, atopic dermatitis, psoriasis) have a strong correlation with the emotional status of the patient [69,70,71,72]. It has been shown that there is a negative influence on the immune system causing a greater risk of infections in patients subjected to mild to severe chronic stress [72].…”

Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world's population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone's modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.

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“…Moreover, we showed that the stress hormone GC (i.e., corticosterone) was increased in arthritic mice compared with that in control mice, and further increases were observed in stressed arthritic mice. Stress worsens skin diseases, such as psoriasis, and this phenomenon could be related to defects in the hypothalamic-pituitary-adrenal (HPA)-axis, altered glucocorticosteroid availability, or GCR dysfunction [27]. Because corticosterone generally has immunosuppressive effects, this hormone decreases IL-6 levels but stimulates; however, IL-2 plus corticosterone treatment increases IL-6 [28].…”

Section: Discussionmentioning

confidence: 99%

Deterioration of dry skin in arthritis model mice via stress-induced changes in immune cells in the thymus and spleen

Goto

Hiramoto

Takada

et al. 2019

Preprint

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19Skin dryness is a characteristic of rheumatoid arthritis model mice. We previously reported 20 that the stress hormone glucocorticoid (i.e., corticosterone) is related to the induction of dry 21 skin in arthritic mice. However, the mechanism through which stress induces dry skin in 22 these mice is still unclear. Therefore, in this study, we examined the relationship between 23 stress and induction of dry skin in arthritic mice. Physical stress load in mice with 24 DBA/1JJmsSlc collagen-induced arthritis was treated with water immersion stress, and 25 transepidermal water loss and the expression of markers associated with allergic reactions 26 and inflammation was evaluated. Deterioration of skin dryness was observed in stressed 27 arthritic mice compared with that in unstressed arthritic mice. Moreover, plasma levels of 28 interleukin-6 and corticosterone were increased in stressed arthritic mice compared with 29 those in unstressed arthritic mice. We also observed decreased regulatory T cell numbers and 30 increased T helper type 2 cell numbers in the thymus of stressed arthritic mice compared with 31 those in unstressed arthritic mice. These results suggested that abnormalities in the immune 32 system were related to deterioration of dry skin in stressed arthritic mice. Thus, reduction of 33 stress may prevent deterioration of dry skin in mice with arthritis. 34 36 37 corticotropin-releasing hormone production, leading to increased secretion of 57 adrenocorticotropic hormone by the pituitary gland [12]. These changes caused increased 58 synthesis and secretion of GC from the adrenal glands. GC has anti-inflammatory effects, but 59 induces abnormalities in the structure and function of the skin by upregulating Toll-like 60 receptor 2 [13]. Furthermore, treatment with the GC receptor (GCR) inhibitor RU486 61ameliorates dry skin in arthritic mice [11]. Accordingly, stress is related to induction of dry 62 skin in arthritic mice. Additionally, stress is involved in the onset of RA itself [14]. However, 63 despite these studies, the mechanisms through which stress induces dry skin in arthritic mice 64 are still unclear. 65In this study, we evaluated the effects of water immersion stress on dry skin in 66 arthritic mice. 67 MATERIALS AND METHODS 68Animals 69 Specific pathogen-free DBA/1JJmsSlc mice (10 weeks old) were obtained from Japan SLC 70 (Hamamatsu, Shizuoka, Japan). We used these mice as a collagen-induced arthritic mouse 71 model. The method for inducing arthritis in these mice was described previously [11]. The 72 mice were housed under a 12:12-h light/dark cycle at a constant temperature of 23°C ± 2°C 73 and 55% ± 10% relative humidity. The mice had free access to water and laboratory chow 74 (CE-2; Oriental Yeast Co., Tokyo, Japan). All animals were treated in accordance with the 76 (approval number: 66). All experiments were performed under sodium pentobarbital 77 anesthesia. 78Experimental design 79 After allowing the mice to acclimate for 1 week, stress treatment was applied for 4 days, and 80 mi...

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Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis

Cited by 22 publications

References 83 publications

New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice

New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice

Environmental risk factors and epigenetic alternations in psoriasis

Deterioration of dry skin in arthritis model mice via stress-induced changes in immune cells in the thymus and spleen

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