Chronic spatial working memory deficit associated with the superior longitudinal fasciculus: a study using voxel-based lesion-symptom mapping and intraoperative direct stimulation in right prefrontal glioma surgery

Kinoshita, Masashi; Nakajima, Riho; Shinohara, Harumichi; Miyashita, Katsuyoshi; Tanaka, Shingo; Okita, Hirokazu; Nakada, Mitsutoshi; Hayashi, Yutaka

doi:10.3171/2015.10.jns1591

Cited by 67 publications

(44 citation statements)

References 45 publications

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“…FAT расположен по задней границе опухоли и тесно прилежит к ней; д -интраоперационное фото: 0, 2, 3, 41 -зоны нарушений речи в ложе раны, полученные при прямой электрической стимуляции; обращает на себя внимание топография выявленных зон, соответствующая ходу волокон FAT; е -МРТ после операции в первые 72 ч. Стрелкой обозначена гемостатическая метка (оставленный в полости ложа по заднему контуру опухоли фрагмент гемостатической марли в зоне найденных при электрической стимуляции речевых нарушений), ж -послеоперационная МР-трактография: желтым цветом обозначен AF, синим -FAT, зеленым цветом выделены остатки опухоли. ционного исследования у больных с эпилепсией или опухолями головного мозга, подкорковые волокна таким способом оценить нелегко [22].…”

Section: Discussionunclassified

Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe

et al. 2018

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Surgery of intracerebral tumors involving long association fibers is a challenge. In this study, we analyze the results of intraoperative mapping of the superior longitudinal, arcuate, and frontal aslant tracts in surgery of brain gliomas. Purpose. The study purpose was to compare the results of intraoperative mapping and the postoperative speech function in patients with gliomas of the premotor area of the speech-dominant frontal lobe, which involved the superior longitudinal, arcuate, and frontal aslant tracts, who were operated on using awake craniotomy. Material and methods. Twelve patients with left frontal lobe gliomas were operated on: 11 patients were right-handed, and one patient was a left-hander retrained at an early age. Histological types of tumors were represented by Grade II diffuse astrocytomas (6 patients), Grade III anaplastic astrocytomas (1 patient), Grade IV glioblastoma (1 patient), Grade II oligodendroglioma (1 patient), and Grade III anaplastic oligodendrogliomas (3 patients). The mean age of patients was 45 (29-67) years; there were 6 males and 6 females. All patients underwent preoperative and postoperative MRI with reconstruction of the long association fibers and determination of the topographic anatomical relationships between the fibers and the tumor. Surgery was performed using the asleep-awake-asleep protocol with intraoperative awakening of patients. All patients underwent cortical and subcortical electrophysiological stimulation to control the localization of eloquent structures and to clarify the safe limits of resection. For intraoperative speech monitoring, a computerized naming test was used with naming of nouns or verbs, and automatic speech was evaluated (counting from 1 to 10, enumeration of months and days of the week), which was complemented by a talk with the patient. Speech disorders before, during, and after surgery were evaluated by a neuropsychologist. The mean current strength during direct electrical stimulation was 3 (1.9-6.5) mA. Results. The association fibers were intraoperatively identified in all patients (SLF/AF in 11 patients; FAT in one patient). In 4 patients, the cortical motor speech area was intraoperatively mapped; in three cases, tumor resection was accompanied by speech disturbances outside the stimulation. During direct electrical stimulation, speech disturbances developed in 7 of 12 cases. All patients underwent control MRI within the first 48-72 h: total resection (more than 90% of the tumor) was performed in 7 cases; subtotal resection was achieved in two patients; partial resection was performed in two cases. According to postoperative MR tractography, the resected tumor bed was adjacent to the SLF/AF complex in 7 cases, located near the SLF/AF complex in three cases, and adjacent to the FAT in two cases. Postoperatively, 11 out of 12 patients had worsening of neurological symptoms in the form of various speech disturbances. In one patient, speech disturbances developed 2 days after surgery, which was associated with an increase in edema. On e...

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Section: Discussionunclassified

Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe

et al. 2018

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“…Neuroimaging studies have implicated the frontal and posterior parietal cortices in working memory . This coordination is likely supported by the SLF, and several studies have demonstrated a relationship between the SLF and working memory . A DTI study of individuals with Gulf War illness showed a correlation between abnormality of the right SLF and fatigue .…”

Section: Discussionmentioning

confidence: 99%

“…28,29 This coordination is likely supported by the SLF, and several studies have demonstrated a relationship between the SLF and working memory. 30,31 A DTI study of individuals with Gulf War illness showed a correlation between abnormality of the right SLF and fatigue. 32 Thus, dysfunction in the right SLF may underlie some of the core affective symptoms seen in ME/CFS.…”

Section: Discussionmentioning

confidence: 99%

Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging

Kimura

Sato

Ota

et al. 2018

Magnetic Resonance Imaging

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Background Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor imaging (DTI). Purpose To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI and NODDI metrics. Study Type Prospective. Population Twenty ME/CFS patients and 23 healthy controls were recruited. Field Strength/Sequence Three‐b value DWI (b‐values = 0, 1000, and 2000 sec/mm2) and 3D T1‐weighted images were at 3.0T. Assessment Mean kurtosis (MK), neurite density index (NDI), orientation dispersion index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were calculated. Statistical Testing The two‐sample t‐test analysis in SPM12 software was used to compare the differences between ME/CFS and control groups. Results In the ME/CFS patients, we observed significant FA decreases in the genu of the corpus callosum and the anterior limb of the right internal capsule (P < 0.05), but no significant difference in MD (P = 0.164); there were also significant MK decreases in the right frontal area, anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and left parietal area (P < 0.05). Significant NDI decreases were observed in the right posterior cingulate gyrus, SLF, and left frontal area of the ME/CFS patients (P < 0.05). Significant ODI decreases were seen in the bilateral occipital areas, right superior temporal gyrus, the anterior limb of internal capsule, and the posterior cingulate gyrus (P < 0.05), and significant ODI increases were revealed in the bilateral occipital and right temporal areas (P < 0.05). Data Conclusion Right SLF abnormalities may be a diagnostic marker for ME/CFS. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:818–824.

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“…21,37) Our previous study suggested that spatial working memory would be performed via parieto-frontal networks, especially with the right SLF I and II, damage to which caused chronic impairment of this function. 38) …”

Section: White Matter Tracts and Dessmentioning

confidence: 99%

Critical Neural Networks in Awake Surgery for Gliomas

Kinoshita

Miyashita

Tsutsui

et al. 2016

Neurol. Med. Chir.(Tokyo)

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From the embarrassing character commonly infiltrating eloquent brain regions, the surgical resection of glioma remains challenging. Owing to the recent development of in vivo visualization techniques for the human brain, white matter regions can be delineated using diffusion tensor imaging (DTI) as a routine clinical practice in neurosurgery. In confirmation of the results of DTI tractography, a direct electrical stimulation (DES) substantially influences the investigation of cortico-subcortical networks, which can be identified via specific symptoms elicited in the concerned white matter tracts (eg., the arcuate fascicle, superior longitudinal fascicles, inferior fronto-occipital fascicle, inferior longitudinal fascicle, frontal aslant tract, sensori-motor tracts, optic radiation, and so forth). During awake surgery for glioma using DES, it is important to identify the anatomo-functional structure of white matter tracts to identify the surgical boundaries of brain regions not only to achieve maximal resection of the glioma but also to maximally preserve quality of life. However, the risk exists that neurosurgeons may be misled by the inability of DTI to visualize the actual anatomy of the white matter fibers, resulting in inappropriate decisions regarding surgical boundaries. This review article provides information of the critical neuronal network that is necessary to identify and understand in awake surgery for glioma, with special references to white matter tracts and the author’s experiences.

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Chronic spatial working memory deficit associated with the superior longitudinal fasciculus: a study using voxel-based lesion-symptom mapping and intraoperative direct stimulation in right prefrontal glioma surgery

Cited by 67 publications

References 45 publications

Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe

Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe

Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging

Critical Neural Networks in Awake Surgery for Gliomas

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