Chronic spontaneous urticaria: cutaneous reaction and laboratory aspects

Campos, Vitor Celso M.; Yassumoto, Letícia; Filho, Odilon M. Almeida; Antunes, Roseli N. S.; Calamita, Zamir

doi:10.5935/1676-2444.20160020

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…Our study revealed a prevalence of ANA positivity of 31%, which was slightly higher than other studies. The prevalence of ANA-positive CSU patients has varied from 10.5% to 29% in other studies [ 21 – 26 ] ( Table 3 ). This may be explained by the different sensitivity and specificity of testing methods and technician experience (14) and ethnic differences in the study populations.…”

Section: Discussionmentioning

confidence: 93%

“…Urticaria Activity Score summed over 7 days (UAS7) quantifies the daily quantity of wheals (range: 0-none to 3-severe) and daily severity of pruritus (range: 0-none to 3-severe) for seven consecutive days with a maximum weekly score of 42 [15]. UAS7 severity scores are classified as severe urticaria (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42), moderate urticaria (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), and mild urticaria (0-15). UAS7 scores were recorded by each subject during the seven days prior to each visit.…”

Section: Duration Of Treatment Andmentioning

confidence: 99%

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Do Antinuclear Antibodies Influence the Clinical Features of Chronic Spontaneous Urticaria?: A Retrospective Cohort Study

Arunkajohnsak

Jiamton

Tuchinda

et al. 2022

BioMed Research International

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Background. Antinuclear antibody (ANA) is often used as a screening test for autoimmune comorbidities in patients with chronic spontaneous urticaria (CSU). However, the relationship of ANA status and the clinical course of the disease have not been fully described. Objectives. To compare clinical features of CSU patients who are positive and negative for ANA. Methods. This was a retrospective cohort study that enrolled CSU patients attending the Urticaria Clinic at Siriraj Hospital from 2013 to 2019. Demographics, clinical characteristics, laboratory investigations, and treatments were collected until July 2021. All patients were investigated for ANA. Clinical feature data was compared between CSU patients with positive ANA and negative ANA groups using the 2-sample t -test and the Mann–Whitney U test for quantitative variables. The chi-squared test or Fisher’s exact test was conducted to explore the association of qualitative variables. Disease relapse and remission were analysed via Kaplan-Meier survival analysis. Results. Of 323 CSU patients, 31% had positive ANA. There were no significant differences in disease severity or impairment in quality of life. Patients with a positive ANA test had significantly lower prevalence of allergic rhinitis ( p = .048 ) and significantly higher level of erythrocyte sedimentation rate ( p = 0.007 ). Kaplan-Meier survival analysis showed that 2% of ANA positive CSU patients achieved remission status after one year and 28% did so after five years. There was no statistically significant difference in time to remission and time to relapse between ANA-positive and negative groups. Conclusion. Positive ANA in CSU patients could not indicate the differences in main disease characteristics from the ANA-negative CSU patients. Investigation for ANA may be useful in CSU patients who are suspected of having autoimmune diseases.

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Section: Discussionmentioning

confidence: 93%

Section: Duration Of Treatment Andmentioning

confidence: 99%

Do Antinuclear Antibodies Influence the Clinical Features of Chronic Spontaneous Urticaria?: A Retrospective Cohort Study

Arunkajohnsak

Jiamton

Tuchinda

et al. 2022

BioMed Research International

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“…Positive antinuclear antibodies 13/63 (20.6) of CSU 10 248/12,778 (1.9) -131/195 (67.2) of CSU 10,120,155,158,160,196,197 Elevated erythrocyte sedimentation rate 18/63 (28.6) 10 3/184 (1.6) -65/133 (48.9) 10,74,155,160,165,172,178,198 Elevated total serum IgE c NA 14/330 (4.2) -34/62 (54.8) 12,28,36,74,165,[199][200][201] Positive ASST 11/61 (18.0) -3/5 (60.0) of CSU 20,37,40,42 12/45 (26.7) -49/67 (73.1) of CSU 10,28,36,37,40,74,108,111,130,142,150,155,156,160,168,196,[202][203][204][205]…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Prevalence, Clinical Manifestations, Treatment, and Clinical Course of Chronic Urticaria in Elderly: A Systematic Review

Kulthanan¹,

Rujitharanawong²,

Munprom³

et al. 2022

JAA

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Purpose Data specific to the epidemiology, clinical features, and management of chronic urticaria (CU) in the geriatric population remain limited and not well understood. We aim to systematically review the prevalence, clinical manifestations, treatment, and clinical course of elderly patients with CU. Patients and methods Original articles that included data of elderly (aged >60 years) with CU that were published until February 2021 were searched in PubMed, Scopus, and Embase using predfefined search terms. Related articles were evaluated according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Results Among the included 85 studies and 1,112,066 elderly CU patients, most (57.4%) were women. The prevalence of elderly CU in the general population ranged from 0.2–2.8%, and from 0.7–33.3% among all CU patients. Compared to adult CU, elderly CU patients had a higher percentage of wheal alone (73.9%), and lower rate of positive autologous serum skin test and atopy. Gastrointestinal diseases were the most common comorbidity (71.9%), and there was a high rate of malignancies and autoimmune diseases. Second generation H 1 -antihistamines were commonly used, and achievement of complete control was most often reported. Omalizumab was prescribed in 59 refractory patients, and a significant response to treatment was reported in most patients. The treatment of comorbidities also yielded significant improvement in CU. Conclusion Elderly CU was found to be different from adult CU in both clinical and laboratory aspects. H 1 - antihistamines are effective as first-line therapy with minimal side-effects at licensed doses. Treatment of secondary causes is important since the elderly usually have age-related comorbidities.

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Chronic spontaneous urticaria: cutaneous reaction and laboratory aspects

Cited by 2 publications

References 2 publications

Do Antinuclear Antibodies Influence the Clinical Features of Chronic Spontaneous Urticaria?: A Retrospective Cohort Study

Do Antinuclear Antibodies Influence the Clinical Features of Chronic Spontaneous Urticaria?: A Retrospective Cohort Study

Prevalence, Clinical Manifestations, Treatment, and Clinical Course of Chronic Urticaria in Elderly: A Systematic Review

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