2024
DOI: 10.1002/eji.202451299
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Chronic stimulation desensitizes β2‐adrenergic receptor responses in natural killer cells

Martin Jürgens,
Maren Claus,
Sabine Wingert
et al.

Abstract: Adrenergic receptors (ARs) are preferentially expressed by innate lymphocytes such as natural killer (NK) cells. Here, we study the effect of epinephrine‐mediated stimulation of the β2‐adrenergic receptor (β2AR) on the function of human NK cells. Epinephrine stimulation inhibited early NK cell signaling events and blocked the function of the integrin LFA‐1. This reduced the adhesion of NK cells to ICAM‐1, explaining how NK cells are mobilized into the peripheral blood upon epinephrine release during acute stre… Show more

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