Chronic Stress Effects on Sexual Behavior in Male and Female Rats

Gorzalka, Boris B.; Hanson, Laura; Brotto, Lori A.

doi:10.1016/s0091-3057(98)00106-3

Cited by 50 publications

(19 citation statements)

References 54 publications

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“…Males showed a greater number of saline-induced (spontaneous) WDS than females. This finding is consistent with previous experiments showing an increased rate of WDS in males, either spontaneous or DOI-induced (Gorzalka et al 1998). It has also been found that gonadectomy decreases 5-HT 2A mRNA in the hypothalamus, possibly indicating an interaction between the 5-HT 2A receptor and testosterone (Zhang et al 1999).…”

Section: Discussionsupporting

confidence: 94%

Prenatal ethanol exposure in rats alters serotonergic-mediated behavioral and physiological function

Hofmann

Simms

et al. 2002

Psychopharmacology

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Section: Discussionsupporting

confidence: 94%

Prenatal ethanol exposure in rats alters serotonergic-mediated behavioral and physiological function

Hofmann

Simms

et al. 2002

Psychopharmacology

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“…In other social mammals, it is not unusual to find reproduction being influenced by behavioral and environmental factors, although in most cases it is the dominant individual that suppresses reproduction in subordinates [Brant et al, 1998;Creel et al, 1993;Packard et al, 1985]. Some cases of suppressed reproductive activity have been linked to a lack of normal social activity [Arnold and Dittami, 1997;Saltzman et al, 1998;Baker et al, 1999;De Jong et al, 2000;Moberg et al, 2000;Wielebnowski et al, 2002;Gorzalka et al, 1998;Soltis et al, 2003]. Elephants are highly social, but in captivity often are housed in small, unrelated herds.…”

Section: Discussionmentioning

confidence: 99%

Results of a second survey to assess the reproductive status of female Asian and African elephants in North America

2010

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Surveys are being conducted to monitor the reproductive health of elephants managed by the TAG/SSP. This study summarizes results of a 2005 survey and compares data to one conducted in 2002. Surveys were returned for 100% and 79.0% of Asian and African elephants, respectively. Of those, 79.3% of Asian and 92.1% of African elephants had weekly progestagen data to assess ovarian cyclicity. For Asian elephants, acyclicity rates were similar between the 2002 and 2005 surveys (13.3% versus 10.9%), whereas irregular cycling increased in 2005 (2.6% versus 7.6%), respectively. For African elephants, the percentages of both acyclicity (22.0% versus 31.2%) and irregular cycling females (5.2% versus 11.8%) increased. In both species, ovarian inactivity was more prevalent in the older age categories (>30 years of age), but for African elephants also occurred in the reproductive aged groups. Reproductive tract pathologies did not account for the majority of acyclicity problems. Several females changed cyclicity status between the two surveys, including from noncycling to cycling, suggesting this is not an irreversible condition. However, seven African females went from cycling to abnormal or no cyclic activity. In summary, the incidence of ovarian acyclicity in Asian elephants is low and stable, but appears to be increasing in African females. These findings reinforce the need for long-term reproductive monitoring programs and continuous reproductive surveys, even for females not being considered for breeding. With more data we hope to determine what factors are related to changes in ovarian status and how to reverse the trend towards acyclicity.

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“…253 However, the majority of studies in various models found that females are actually less susceptible to the effects of the stress or behave as if they had been administered antidepressants compared to their male counterparts in the model. [254][255][256][257][258][259][260] It is clear that many ethologically relevant behaviors in mice have gender-dependent effects, which may result in an interference with the behavioral readout and subsequent sensitivity to antidepressant drugs. 256,257 It is therefore important to investigate gender differences between various strains of genetically modified mice and to also study how behaviors are influenced by ovarian steroids over the estrous cycle.…”

Section: Are There Strain Differences?mentioning

confidence: 99%

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

2004

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The ability to modify mice genetically has been one of the major breakthroughs in modern medical science affecting every discipline including psychiatry. It is hoped that the application of such technologies will result in the identification of novel targets for the treatment of diseases such as depression and to gain a better understanding of the molecular pathophysiological mechanisms that are regulated by current clinically effective antidepressant medications. The advent of these tools has resulted in the need to adopt, refine and develop mouse-specific models for analyses of depression-like behavior or behavioral patterns modulated by antidepressants. In this review, we will focus on the utility of current models (eg forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, drug-withdrawal-induced anhedonia) and research strategies aimed at investigating novel targets relevant to depression in the mouse. We will focus on key questions that are considered relevant for examining the utility of such models. Further, we describe other avenues of research that may give clues as to whether indeed a genetically modified animal has alterations relevant to clinical depression. We suggest that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depressionrelated pathology.

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Chronic Stress Effects on Sexual Behavior in Male and Female Rats

Cited by 50 publications

References 54 publications

Prenatal ethanol exposure in rats alters serotonergic-mediated behavioral and physiological function

Prenatal ethanol exposure in rats alters serotonergic-mediated behavioral and physiological function

Results of a second survey to assess the reproductive status of female Asian and African elephants in North America

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

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