Chronic stress in nonelderly caregivers

Vedhara, Kavita; McDermott, Michael P.; Evans, Thomas G.; Treanor, John J.; Plummer, Sue; Tallon, Deborah; Cruttenden, Kim; Schifitto, Giovanni

doi:10.1016/s0022-3999(02)00343-4

Cited by 77 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies that have examined the antibody response to medical vaccination in younger caregivers have reported inconsistent results. The first study of this type compared hormonal and immune status between 41 partner of multiple sclerosis patients and 62 controls (Vedhara et al 2002). Multiple sclerosis was chosen as a serious chronic and degenerative illness that usually causes physical and cognitive complications (Barcellos et al 2002), and as such thought to cause equivalent level of burden for caregivers as seen in spouses and partners of dementia patients.…”

Section: Psychological Stress and Immunitymentioning

confidence: 99%

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Vitlić

Lord

Phillips

2014

AGE

103

View full text Add to dashboard Cite

The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens. It is a complex system that consists of a large number of components performing different functions. The adequate and controlled interaction between these components is necessary for a robust and strong immune response. There are, however, many factors that interfere with the way the immune response functions. Stress and ageing now consistently appear in the literature as factors that act upon the immune system in the way that is often damaging. This review focuses on the role of stress and ageing in altering the robustness of the immune response first separately, and then simultaneously, discussing the effects that emerge from their interplay. The special focus is on the psychological stress and the impact that it has at different levels, from the whole system to the individual molecules, resulting in consequences for physical health.

show abstract

Section: Psychological Stress and Immunitymentioning

confidence: 99%

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Vitlić

Lord

Phillips

2014

AGE

103

View full text Add to dashboard Cite

show abstract

“…In studies focused on the daily profiles of HPA activity in caregivers, elevated daytime cortisol levels during the entire day together with greater emotional distress have been reported in elderly caregivers of dementia patients (Vedhara et al, 1999). However, low levels of cortisol together with a lack of variation in anxiety and depression have been found in middle-aged caregivers of multiple sclerosis patients (Vedhara et al, 2002). In younger caregivers, elevated daytime cortisol levels, likely associated with behavioral problems of the care recipient, have been reported (Seltzer et al, 2009; however, low levels of cortisol have been found in caregivers of children with cerebral palsy (Bella et al, 2011).…”

mentioning

confidence: 99%

Salivary cortisol and immunoglobulin A: Responses to stress as predictors of health complaints reported by caregivers of offspring with autistic spectrum disorder

Andrés-García

Moya-Albiol

González-Bono

2012

Hormones and Behavior

View full text Add to dashboard Cite

“…Many studies [14,24,36,37,38,39,40] have shown that stress can alter the immune function. The central nervous system, the endocrine system and the immune system are complex systems that interact with each other, and stressors can change immune responses by affecting the interaction of these systems [39].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies [12,17,38,43,44] explained that chronic stress reduces both humoral and cellular immune responses against influenza infections. Additionally, it has been shown that this type of stress decreases the efficiency of current influenza vaccines in the induction of protective immune responses in vaccinated groups [17,19,20,38].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Suppressive Effects of Chronic Stress on Influenza Virus Protection after Vaccination with Plasmid DNA-Encoded Nucleoprotein

Nezam

Hosseini

Kheiri³

et al. 2015

Neuroimmunomodulation

View full text Add to dashboard Cite

Background: Influenza is a highly infectious and acute respiratory disease caused by an infection of the host respiratory tract mucosa by the influenza virus. The use of DNA vaccines that express conserved genes such as nucleoprotein (NP) represents a new method of vaccination against influenza. In this study, the effect of chronic stress on the efficiency of this type of vaccine has been evaluated in a mouse model. Methods: The NP DNA vaccine was administered intradermally 3 times on days 0, 3 and 6 to stressed and nonstressed male BALB/c mice. Two weeks after the last immunization, half of these mice were challenged with A/Puerto Rico/8/34 (PR8) influenza virus and were weighed for 12 days, and their mortality rate was assessed during this period. The cellular immune response of the other half of the mice was evaluated by cytotoxicity assay. Results: The results indicate a significant reduction in the cytotoxic T-lymphocyte response of stressed mice in comparison with unstressed mice. Also, the percentage of weight loss and mortality after the challenge in stressed mice was significantly increased compared to the other group. Conclusion: These results indicate that the NP DNA vaccine is not able to induce any effective cytotoxic T-lymphocyte response against influenza virus in stressed mice and cannot induce protective immunity against influenza infection in this group of mice.

show abstract

Chronic stress in nonelderly caregivers

Cited by 77 publications

References 22 publications

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Salivary cortisol and immunoglobulin A: Responses to stress as predictors of health complaints reported by caregivers of offspring with autistic spectrum disorder

Suppressive Effects of Chronic Stress on Influenza Virus Protection after Vaccination with Plasmid DNA-Encoded Nucleoprotein

Contact Info

Product

Resources

About