Chronic stress in pregnant rats: effects on growth rate, anxiety and memory capabilities of the offspring

Lordi, B; Patin, V; Protais, P.; Mellier, Daniel; Caston, J.

doi:10.1016/s0167-8760(00)00100-8

Cited by 79 publications

(43 citation statements)

References 29 publications

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“…As regards the body weight of the breeding evaluated in P0, a considerably lower weight was presented by the S group compared to the control group, results that coincide with other studies (Lordi et al, 2000;Minagi et al, 2009); an evaluation of stressed female's breeding during the last trimester of gestation.…”

Section: Discussionsupporting

confidence: 87%

Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

2012

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SUMMARY:Prenatal stress has been associated with alterations in weight and body size, as well as disturbances in the process of developing skeletal ossification, occurring during childbirth and the early stages of life. However, the effect evidence of prenatal stress on bone growth and development during the gestation period has been low; therefore, it is unknown whether these alterations are associated with potential for growth disorders Because of this, the study aims to determine the short-term effects of prenatal stress on the CF-1 mouse bone structure growth in your date of birth. The female mice were divided randomly in two groups: controlled (n=2) and stressed (n=3). The latter was put under stress by means of movement restriction during the last week of gestation. Second, an evaluation of their gestational development was made, obtaining measurements of their weight. Finally, diaphanization with KOH and staining with Alizarin red was used to measure the length of their appendicular bones and their flat pelvic bones, of 53 P0 mice (25 control; 28 stressed during gestation). The stressed mice's body weight (p=0.02) and the length of their appendicular bones (radii, p=0.0011; ulnae, p= 0.0001; humeri, p=0.0001; femorae, p=0.0006; tibiae, p=0.0015) were affected significantly in contrast with the controlled group. On the other hand, there were no significant differences in maternal body weight and length of the mice pelvic bones (isquium, ilium; p>0.05). The prenatal stress by means of movement restriction alters the osseous appendicular morphology of the CF-1 mouse evaluated at birth.

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Section: Discussionsupporting

confidence: 87%

Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

2012

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“…This result is in agreement with the study by Lordi et al, (2000), who evaluated the offspring of females stressed during the last trimester of gestation. These results can be explained by two mechanisms associated with the effect of GCs and catecholamines on the developing fetus: the first states that the GCs cause an increase in circulating glucose, an alteration of insulin receptors and an increase in lipolysis, leading to lower weight at birth in comparison with control animals (Ain et al, 2005).…”

Section: Discussionsupporting

confidence: 93%

Prenatal Stress Caused by Movement Restriction Induces Changes in the Development of Skull Bone in CF-1 Mice Progeny

et al. 2013

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SUMMARY:Prenatal stress is associated with changes in body weight and size, and with disorders of the skeletal bone development process. However, there is a lack of documentation on the impact of prenatal stress on skull bone anatomy during the gestation period. Therefore, this research focuses on the short-term effects of prenatal stress on the skull bone anatomy of CF-1 mice on the day of birth. Methodology: Gestating females were divided at random into two groups (control and stressed). The experimental group was subjected to the stress of movement restriction during the final week of gestation. Upon birth the body weight of the progeny was evaluated (control group, n=34; stressed group, n=29). They were then cleaned and stained with alizarin red in order to evaluate the length, width and suture spaces of the skull bone anatomy from superior and inferior views. Results: Gestational stress significantly altered the skull bone anatomy (p<0.05) of the offspring at birth in comparison with the control group. Conclusion: Prenatal stress alters the skull bone anatomy of the CF-1 mouse at birth.

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“…In contrast, other studies using a similar experimental model showed that maternal stress induced high anxiety-like behavior in adult offspring without any influence on spatial learning (Vallee et al, 1997). It was also shown that repeated emotional stress on the 19th day of pregnancy is sufficient to induce a defect in conditioned memory but not anxiety (Lordi et al, 2000).…”

Section: Introductionmentioning

confidence: 87%

Maternal Stress Produces Learning Deficits Associated with Impairment of NMDA Receptor-Mediated Synaptic Plasticity

Geum²,

et al. 2006

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Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochemical analysis demonstrated a substantial decrease in NR1 and NR2B subunits of the NMDA receptor in synapses of the hippocampus, and the interaction between these two subunits appeared to be reduced. These results suggest that prolonged maternal stress leads to long-lasting malfunction of the hippocampus, which extends to and is manifested in adulthood.

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Chronic stress in pregnant rats: effects on growth rate, anxiety and memory capabilities of the offspring

Cited by 79 publications

References 29 publications

Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

Prenatal Stress Caused by Movement Restriction Induces Changes in the Development of Skull Bone in CF-1 Mice Progeny

Maternal Stress Produces Learning Deficits Associated with Impairment of NMDA Receptor-Mediated Synaptic Plasticity

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