Chronic stress-induced changes in REM sleep on theta oscillations in the rat hippocampus and amygdala

Hegde, Preethi; Jayakrishnan, H.R.; Chattarji, Sumantra; Kutty, Bindu M.; Laxmi, T. Rao

doi:10.1016/j.brainres.2011.01.055

Cited by 25 publications

(16 citation statements)

References 67 publications

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“…Furthermore, nighttime locomotor activity was unaffected in the unilateral VTH-stimulated animals, which is of particular interest due to the role of the hypothalamus in the regulation of autonomic tone, circadian rhythm and sleep-wakefulness. Disturbance in these functions are associated with chronic stress and may lead to somatic and psychiatric disorders [38,41,42]. The present study, however, provides no information on whether VTH DBS has any effect on body weight or if the cardiocerebrovascular reaction to acute stimulation is transient like the aggressive behavior.…”

Section: Discussioncontrasting

confidence: 43%

Hypothalamic Deep Brain Stimulation Influences Autonomic and Limbic Circuitry Involved in the Regulation of Aggression and Cardiocerebrovascular Control in the Göttingen Minipig

Ettrup

Sørensen²,

Rodell³

et al. 2012

Stereotact Funct Neurosurg

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Background: Deep brain stimulation (DBS) in the ventral tuberal hypothalamus (VTH) is currently under investigation for the treatment of severe obesity. Stimulation impact on a number of closely related hypothalamic neural systems could potentially influence normal hypothalamic function and thereby generate adverse side effects. Objective: To assess the feasibility and safety of VTH DBS in a non-primate large animal model. Methods: In the VTH of 6 Göttingen minipigs, quadropolar leads were implanted bilaterally (n = 2) or unilaterally (n = 4), using optimized MRI sequences allowing identification of major diencephalic landmarks. Heart rate, weight, behavior and nighttime locomotor activity were recorded throughout the study period. Two of the unilaterally implanted minipigs were examined with [¹⁵O]H₂O positron emission tomography (PET) scans performed in DBS-off and DBS-on mode. Results: VTH DBS elicited an amplitude-dependent increase in heart rate and transient aggressive behavior. PET demonstrated that VTH DBS caused a global increase in cerebral blood flow velocities and decreased mean transit time. Conclusions: VTH DBS results in behavioral and physiological changes, which may derive from activation of closely related limbic and autonomic networks. Caution and further studies of longer length should be requested before this procedure is used more widely in humans.

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Section: Discussioncontrasting

confidence: 43%

Hypothalamic Deep Brain Stimulation Influences Autonomic and Limbic Circuitry Involved in the Regulation of Aggression and Cardiocerebrovascular Control in the Göttingen Minipig

Ettrup

Sørensen²,

Rodell³

et al. 2012

Stereotact Funct Neurosurg

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“…There is evidence that the functional efficiency of REM sleep may vary both in pathological and normal conditions. For example, chronic stress in rats has been found to synchronize the theta rhythm between the hippocampus and amygdala, which was accompanied by increased amounts of REM sleep (Hegde et al, 2011). Further, Pellicciari et al (2013) provide evidence for functional inefficiency of REM sleep alpha activity in depression in humans, which can be remediated by repetitive trans-cranial magnetic stimulation.…”

Section: Discussionmentioning

confidence: 99%

Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children

et al. 2017

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Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral functions in children with common developmental psychiatric conditions compared to typically developing children (TDC). Twenty-four children with attention-deficit/hyperactivity disorder (ADHD), 21 with Tourette syndrome/tic disorder (TD), 21 with ADHD/TD comorbidity, and 22 TDC, matched for age and gender, underwent a two-night PSG, and their psychopathological scores and intelligence quotient (IQ) were assessed. Major PSG findings showed more REM sleep and shorter REM latency in the children with psychiatric disorders than in the TDC. Multiple regression analyses revealed that in groups with developmental psychopathology, REM sleep proportion correlated positively with scores of inattention and negatively with performance IQ. In contrast, in the group of TDC, REM sleep proportion correlated negatively with scores of inattention and positively with performance IQ. Whilst shorter REM latency was associated with greater inattention scores in children with psychopathology, no such an association existed in the group of TDC. Altogether, these results indicate an opposite impact of REM sleep on neurobehavioral functioning, related to presence or absence of developmental psychiatric disorders. Our findings suggest that during development, REM sleep functions may interact dissimilarly with different pathways of brain maturation.

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“…Attenuation of theta activity in the hippocampus and amygdala has been observed after chronic stress in rats [48]. In addition to peripheral changes in stress hormone levels, the stress situation may also influence central structures implicated in cognitive processes such as the hippocampus and amygdala.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Ahnaou

Drinkenburg²

2016

Neuropsychobiology

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Depression is a heterogeneous disorder characterized by alterations at psychological, behavioural, physiological, neurophysiological, and neurochemical levels. Social stress is a prevalent stress in man, and the repeated social defeat stress model in rats has been proposed as being the rodent equivalent to loss of control, which in subordinate animals produces alterations that resemble several of the cardinal symptoms found in depressed patients. Here, rats followed a resident-intruder protocol for 4 consecutive days during which behavioural, physiological, and electroencephalographic (EEG) parameters were simultaneously monitored in subordinate rats. On day 5, prefrontal dopamine (DA) and hippocampal serotonin (5-HT) as well as corticosterone were measured in submissive rats that had visual, acoustic, and olfactory (but no physical) contact with a dominant, resident conspecific rat. Socially defeated rats demonstrated increases in ultrasonic vocalizations (20-25 KHz), freezing, submissive defensive behaviour, inactivity, and haemodynamic response, while decreases were found in repetitive grooming behaviour and body weight. Additionally, alterations in the sleep-wake architecture were associated with reduced active waking, enhanced light sleep, and increased frequency of transitions from light sleep to quiet wakefulness, indicating sleep instability. Moreover, the attenuation of EEG power over the frequency range of 4.2-30 Hz, associated with a sharp transient increase in delta oscillations, appeared to reflect increased brain activity and metabolism in subordinate animals. These EEG changes were synchronous with a marked increase in body temperature and a decrease in locomotor activity. Furthermore, psychosocial stress consistently increased 5-HT, DA, and corticosterone levels.The increased levels of cortical DA and hippocampal 5-HT during social threat may reflect a coping mechanism to promote alertness and psychological adaptation to provocative and threatening stimuli. These neurophysiological changes are hypothesized to be the consequence of dynamics in monoamine systems, which could be useful markers for disease progression in the aetiology of depression.

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Chronic stress-induced changes in REM sleep on theta oscillations in the rat hippocampus and amygdala

Cited by 25 publications

References 67 publications

Hypothalamic Deep Brain Stimulation Influences Autonomic and Limbic Circuitry Involved in the Regulation of Aggression and Cardiocerebrovascular Control in the Göttingen Minipig

Hypothalamic Deep Brain Stimulation Influences Autonomic and Limbic Circuitry Involved in the Regulation of Aggression and Cardiocerebrovascular Control in the Göttingen Minipig

Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

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