Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways

Bittar, Thibault P.; Pelaez, Mari Carmen; Silva, Jose Cesar Hernandez; Quessy, Francis; Lavigne, Andrée-Anne; Morency, Daphnée; Blanchette, Léa-Jeanne; Arsenault, Elizabeth; Chérasse, Yoan; Seigneur, Josée; Timofeev, Igor; Sephton, Chantelle F.; Proulx, Christophe D.; Labonté, Benoit

doi:10.1016/j.biopsych.2021.02.014

Cited by 36 publications

(35 citation statements)

References 78 publications

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“…Overall, the sum of evidence reported here suggests that chronic stress induces a global reorganization of neuronal spine and arborization in the mPFC, disrupting the frontotemporal neuronal network's integrity differently in males and females (Sarkar and Kabbaj, 2016;Bittar et al, 2021). Importantly, these sex-specific changes, affecting excitatory and inhibitory neuronal populations are likely to interfere with the balance between excitatory and inhibitory (E/I) tones required to maintain proper function of the mPFC (Fee et al, 2017).…”

Section: E/i Balance Integrity In Stressed Males and Femalesmentioning

confidence: 70%

“…In contrast, E/I imbalance in VTAprojecting mPFC neurons was only trending toward excitation with higher excitatory inputs in both sexes but no change in the inhibitory tones imposed over these neurons in both stressed males and females (Bittar et al, 2021). Interestingly, this was corroborated by pathway-specific variations in the expression of GABA and glutamate NMDA receptor subunits (Bittar et al, 2021) as a potential mechanistic explanation for these stressinduced functional changes.…”

Section: E/i Balance Integrity In Stressed Males and Femalesmentioning

confidence: 90%

“…This has been strongly supported by an increasing number of functional studies in animal models of chronic stress dissecting the contribution of the different neuronal circuits of the mPFC in the expression of depressive-like behaviors in males and females ( Vialou et al, 2014 ; Bagot et al, 2015 ; Dolzani et al, 2018 ; Liu W.-Z. et al, 2020 ; Marcus et al, 2020 ; Bittar et al, 2021 ). Here, we review the literature on the involvement of the mPFC and its neuronal circuitry in mediating the expression of depressive-like behaviors.…”

Section: Introductionmentioning

confidence: 91%

“…This complex process appears to involve a series of morphological and anatomical alterations OFT, open field test; sCVS, subthreshold chronic variable stress; SDS, social defeat stress; SPT, sucrose preference test. (Radley et al, 2004;Gilabert-Juan et al, 2013;Sarkar and Kabbaj, 2016;Bittar et al, 2021) combined with changes in the strength of mPFC inputs from several brain structures (Marcus et al, 2020;Bittar et al, 2021). Ultimately, these modifications induced by stress interfere with the E/I balance in the mPFC in a sexspecific fashion and finally with the top-down processing of sensory and emotional information.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Cortico-cortical neurons from layers II/III project to ipsilateral and contralateral cortical areas, while cortico-fugal neurons spread across layers II/III, V, and VI project mainly to subcortical regions. Subsequent differences can be made between cortico-fugal neurons ( Figure 2 ) with NAc-projecting mPFC pyramidal neurons being mainly located in layers II/III and VTA-projecting mPFC neurons being mainly enriched in sublayers V ( Gabbott et al, 2005 ; Kim et al, 2017 ; Bittar et al, 2021 ).…”

Section: Cell Type-specific Distribution and Anatomical Organization Of The Mpfcmentioning

confidence: 99%

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Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

Bittar

Labonté

2021

Front. Behav. Neurosci.

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Despite decades of research on the neurobiology of major depressive disorder (MDD), the mechanisms underlying its expression remain unknown. The medial prefrontal cortex (mPFC), a hub region involved in emotional processing and stress response elaboration, is highly impacted in MDD patients and animal models of chronic stress. Recent advances showed alterations in the morphology and activity of mPFC neurons along with profound changes in their transcriptional programs. Studies at the circuitry level highlighted the relevance of deciphering the contributions of the distinct prefrontal circuits in the elaboration of adapted and maladapted behavioral responses in the context of chronic stress. Interestingly, MDD presents a sexual dimorphism, a feature recognized in the molecular field but understudied on the circuit level. This review examines the recent literature and summarizes the contribution of the mPFC circuitry in the expression of MDD in males and females along with the morphological and functional alterations that change the activity of these neuronal circuits in human MDD and animal models of depressive-like behaviors.

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Section: E/i Balance Integrity In Stressed Males and Femalesmentioning

confidence: 70%

Section: E/i Balance Integrity In Stressed Males and Femalesmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 91%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Cell Type-specific Distribution and Anatomical Organization Of The Mpfcmentioning

confidence: 99%

See 3 more Smart Citations

Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

Bittar

Labonté

2021

Front. Behav. Neurosci.

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Odor awareness modulates the association between perceived stress and chemosensory anhedonia in women

Hu,

Tuluhong,

Han

2024

PsyCh Journal

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Chronic stress alters reward sensitivity and contributes to anhedonia. Chemosensation is dominated by a hedonic dimension, but little is known about the association between chronic perceived stress and hedonic chemosensation in non‐clinical populations. In the current study, 325 participants (201 females) completed a questionnaire‐based survey measuring their chronic perceived stress (Perceived Stress Scale; PSS), chemosensory pleasure (Chemosensory Pleasure Scale; CPS), and olfactory metacognitive abilities (odor awareness, affective impact of odor, importance of olfaction). For females, higher PSS scores significantly predicted lower CPS scores, which is mediated by the positive odor awareness. Moreover, negative odor awareness was identified as a moderator underlying the relationship between PSS and CPS scores in females but not in males. For females, higher PSS predicted lower CPS for those with lower, but not for those with higher levels of negative odor awareness. These results show that the link between chronic perceived stress and chemosensory anhedonia is pronounced in females, with olfactory perception playing a key role. The current study provides insights into the understanding of stress‐related anhedonia and into the development of effective treatments.

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Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review

Barbee

Gourley

2022

Addiction Neuroscience

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Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways

Cited by 36 publications

References 78 publications

Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

Odor awareness modulates the association between perceived stress and chemosensory anhedonia in women

Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review

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