Chronic Stress Is Associated with High Cortisol Levels and Emotional Coping Mechanisms in Amnestic Mild Cognitive Impairment

Souza-Talarico, Juliana Nery de; Chaves, Eliane Corrêa; Nitrini, Ricardo; Caramelli, Paulo

doi:10.1159/000259696

Cited by 15 publications

(11 citation statements)

References 48 publications

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“…Among patients with dementia plus depression, higher MMSE score was significantly associated with higher evening cortisol levels. This is opposite to previous literature (Souza-Talarico et al, 2009, Singh-Manoux et al, 2014. Patients with Alzheimer's dementia often have hippocampal atrophy.…”

Section: Discussioncontrasting

confidence: 99%

“…We did not find such distribution of cortisol levels between the four diagnostic groups. It has been shown that higher cortisol levels are associated with depression (Balardin et al, 2011) and cognition, though the last has been controversial (Singh-Manoux et al, 2014, Souza-Talarico et al, 2009. We found higher cortisol ratio among patients with both dementia and depression as compared to those with either depression or dementia, and the reference group.…”

Section: Discussionmentioning

confidence: 49%

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Cortisol levels among older people with and without depression and dementia

Barca

Eldholm

Persson

et al. 2018

Int. Psychogeriatr.

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Cortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 older people, from the community (home and nursing homes) and specialized care (memory clinics and old age psychiatry wards), mean age 76.8 (SD = 10.3) (dementia n = 319, depression, n = 154, dementia plus depression n = 53, and reference group n = 124), was included. Assessment included the Mini Mental State Examination (MMSE), Cornell scale for depression in dementia, activities of daily living scales, and salivary cortisol. Number of drugs was registered. The results showed that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. Characteristics significantly associated with cortisol levels were higher MMSE score (in patients with dementia and co-morbid depression), male gender (in people with dementia), and number of medications (in the reference group). We conclude that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. The association of cortisol level with MMSE score among patients with dementia and depression could further indicate that increased stress is related to cognitive function.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 49%

Cortisol levels among older people with and without depression and dementia

Barca

Eldholm

Persson

et al. 2018

Int. Psychogeriatr.

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“…This interpretation is endorsed by a study in which elderly individuals presenting light cognitive deficit and higher concentrations of cortisol also displayed higher perception of stress and more frequent memory deficit complaints (21) . These authors believe that the memory deficit perception in some elderly individuals may constitute a stressing factor capable of unleash high- er volumes of cortisol and increase stress perception compared with other elderly individuals who do not present such perception in their daily activities (21) . Notwithstanding, although these findings may support the investigation of such association in longitudinal studies, no cause-effect correlation can be sustained, as these are considered to be cross-sectional studies.…”

Section: Association Between Subjective Memory Complaint and Emotionamentioning

confidence: 94%

Queixa subjetiva de comprometimento da memória em idosos saudáveis: influência de sintomas depressivos, percepção de estresse e autoestima

Santos¹,

Costa

Souza-Talarico

2012

Rev. esc. enferm. USP

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O presente estudo analisou a relação entre percepção de estresse, sintomas depressivos e autoestima em idosos com e sem queixa subjetiva de comprometimento de memória. Foram incluídos 204 idosos (104 sem e 100 com queixa de memória) avaliados a partir do instrumento Memory Assessment Complain Questionnaire (MAC-Q). O protocolo de estudo incluiu a Escala de Estresse Percebido (EEP), a Escala de Depressão Geriátrica (GDS) e a Escala de Autoestima de Rosenberg (EAE). Os idosos com queixa de comprometimento apresentaram escores significativamente maiores na EEP e GDS e menores na EAE (p < 0.001). Foi observada correlação negativa entre o escore do MAC-Q e EPP (p < 0.001) e EAE (p = 0.01). A análise de regressão multivariada identificou somente o estresse como fator preditor da queixa subjetiva de memória. Esses dados sugerem que a percepção de estresse e os sintomas depressivos estão associados com a queixa de memória em idosos.

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“… 74 Moreover, high levels of perceived stress have been associated with elevated cortisol levels in MCI subjects. 75 …”

Section: Acute and Chronic Stress In Alzheimer Dementia-typementioning

confidence: 99%

Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging

Souza-Talarico

Marin

Sindi

et al. 2011

Dement. neuropsychol.

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Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain’s vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer’s disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia.

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Chronic Stress Is Associated with High Cortisol Levels and Emotional Coping Mechanisms in Amnestic Mild Cognitive Impairment

Cited by 15 publications

References 48 publications

Cortisol levels among older people with and without depression and dementia

Cortisol levels among older people with and without depression and dementia

Queixa subjetiva de comprometimento da memória em idosos saudáveis: influência de sintomas depressivos, percepção de estresse e autoestima

Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging

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