Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated ‘hives’

Weisenberg, Scott A.

doi:10.1136/bcr-2017-221877

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…This finding has been previously described in people infected with S . stercoralis [ 46 – 48 ]. This could be explained by the fact that migration of the S .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia

et al. 2022

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Background Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. stercoralis in Ethiopia is underestimated due to the lack of a “Gold” standard diagnostic method. Moreover, its prevalence across altitudinal gradient in Amhara Region has not been studied. Methods A cross-sectional study was conducted among 844 schoolchildren in Amhara Region from April to December 2019. A stool sample was collected from each study participant and processed using formol ether concentration technique (FECT), spontaneous tube sedimentation technique (STST), Baermann concentration technique (BCT), agar plate culture (APC) and real-time polymerase chain reaction (RT-PCR). Data were entered using EpiData and analyzed by SPSS version 23 statistical software. Prevalence of S. stercoralis infection was determined using a single diagnostic technique and combination of techniques. Association of clinical variables with S. stercoralis infection was assessed by logistic regression and independent variables with p<0.05 were considered statistically significant. Results Prevalence of soil-transmitted helminths (STHs) and S. mansoni infections was 38.0% and 20.4%, respectively. Among STHs, the prevalence of hookworm infection was 32.8%. Prevalence of S. stercoralis infection was 39.0%, 28.8%, 10.9%, 10.3%, 4.0% and 2.0% by the respective, combinations of the five methods, RT-PCR, APC, BCT, STST and FECT. The highest prevalence rates, 48.2%, 45.0% and 41.1% of S. stercoralis were recorded in the age group of 12–14 years, males and rural dwellers, respectively. Prevalence rates of S. stercoralis infection in highland, semi-highland and lowland areas were 40.4%, 41.8% and 25.9%, respectively. Having abdominal pain (AOR = 2.48; 95% CI:1.65–3.72), cough (AOR = 1.63;95%CI:1.09–2.42), urticaria (AOR = 2.49;95%CI:1.50–4.01) and being malnourished (AOR = 1.44;95%:1.10–2.01) were significantly associated with strongyloidiasis. Conclusion Prevalence of S. stercoralis infection was high and varied across different altitudes in Amhara Region. Some clinical syndromes were found to be significantly associated with S. stercoralis infection. Therefore, proper diagnosis and preventive strategies against S. stercoralis infection are highly recommended to be devised and implemented in Amhara Region.

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“…This finding has been previously described in people infected with S . stercoralis [ 46 – 48 ]. This could be explained by the fact that migration of the S .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia

et al. 2022

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“…stercoralis es un nematodo que causa parasitosis en los humanos. Tiene un ciclo bastante complejo que finaliza con el depósito de las larvas en el intestino delgado 7,8 , originando una infección latente crónica que podría durar décadas. Dicha infección puede cursar de forma asintomática, pero es posible una reactivación de los síntomas en momentos de inmunosupresión, como podría ser durante un tratamiento con corticoides [5][6][7][8] .…”

Section: Discussionunclassified

Larva <i>currens</i> secundaria a corticoterapia. Reporte de un caso

Liendo-Martínez¹,

Gómez-García²,

Correa-Gutiérrez³

et al. 2023

RPR

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La infección por el nuevo coronavirus (SARS-CoV2) tuvo un tratamiento debatido debido a la incógnita sobre su patogenia, que con el pasar del tiempo se aclaró evidenciándose un componente inflamatorio, siendo la corticoterapia una opción terapéutica. En pacientes con corticoides es primordial conocer las posibles reacciones colaterales por su efecto inmunosupresor. Presentamos el caso de un varón de origen ecuatoriano, de 48 años, que tras infección por SARS-CoV-2 tratada con corticoides presentó exantema serpiginoso que tras serología para Strongyloides stercoralis se confirmó el diagnóstico de larva currens.

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Chronic strongyloidiasis: a case of B symptoms and recurrent asthma exacerbations

Latif

Crupie

2020

BMJ Case Rep

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Strongyloidiasis is one of the neglected helminths infection that is often underdiagnosed and undertreated. Due to its variable presentation, its diagnosis is often a challenge. We report a case of an immigrant patient with asthma who later developed eosinophilia. After 3 years of unexplained eosinophilia, he developed B symptoms and had frequent asthma exacerbations. He was later diagnosed with strongyloidiasis and treated with ivermectin. His B symptoms resolved, and his asthma exacerbations decreased significantly. Due to the frequent use of corticosteroids in asthma exacerbations, this case illustrates the importance of Strongyloides screening in asthmatics from high-risk regions. It also displays the importance of further investigating patients with asthma who develop eosinophilia and have frequent exacerbations while on optimal asthma treatment. Having a high index of suspicion is essential when making this diagnosis, as clinical presentation is often variable and does not follow a standard time course.

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Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated ‘hives’

Cited by 6 publications

References 19 publications

Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia

Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia

Larva <i>currens</i> secundaria a corticoterapia. Reporte de un caso

Chronic strongyloidiasis: a case of B symptoms and recurrent asthma exacerbations

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