Chronic supplementation with dietary proanthocyanidins protects from diet‐induced intestinal alterations in obese rats

Abstract

This study provides evidence for the ameliorative effect of a proanthocyanidin extract on high-fat/high-carbohydrate diet-induced intestinal alterations, specifically reducing intestinal inflammation and oxidative stress and suggesting a protection against a barrier defect.

Protective Effect of Proanthocyanidins in a Rat Model of Mild Intestinal Inflammation and Impaired Intestinal Permeability Induced by LPS

“…It is necessary to emphasize that this effect of GSPE on TJ gene expression profile translates into an overall effect on intestinal permeability, considering the protective role of GSPE against increased OVA levels. [24] In summary, in the present study, LPS administration induced systemic and intestinal inflammation accompanied by the presence of intestinal oxidative stress and increased intestinal permeability. For the first time, a grape seed extract rich in proanthocyanidins has been shown to prevent LPS-induced intestinal dysfunction; however, the effect of the GSPE was different in each intestinal section.…”

“…In the ileal section, the administration of LPS had no effect on the rest of the permeability genes; however, they were slightly susceptible to GSPE. It is necessary to emphasize that this effect of GSPE on TJ gene expression profile translates into an overall effect on intestinal permeability, considering the protective role of GSPE against increased OVA levels …”

“…Specifically, we demonstrated that these bioactive compounds found in a grape seed proanthocyanidin extract (GSPE) had protective effects on intestinal oxidative stress and from barrier disruption by TJ modulation and prevented intestinal inflammation at dietary doses (5,25, and 50 mg kg -1 body weight [bw]). [24] We could also demonstrate the same effects for higher doses of GSPE (500 mg kg -1 bw) considered clearly pharmacological, and we defined that the co-administration of proanthocyanidins and an obesogenic diet prevented the increase in intestinal permeability and metabolic endotoxemia derived to the diet. [25] In addition, we have reported that GSPE administration to rats is able to modify intestinal microbiota richness and diversity significantly.…”

“…In a previous study by our group, we found that dietary doses of a grape seed extract rich in proanthocyanidins had beneficial effects when they were administered in a corrective way, in a diet‐induced obesity model of intestinal dysfunction in rats. Specifically, we demonstrated that these bioactive compounds found in a grape seed proanthocyanidin extract (GSPE) had protective effects on intestinal oxidative stress and from barrier disruption by TJ modulation and prevented intestinal inflammation at dietary doses (5, 25, and 50 mg kg –1 body weight [bw]) . We could also demonstrate the same effects for higher doses of GSPE (500 mg kg –1 bw) considered clearly pharmacological, and we defined that the co‐administration of proanthocyanidins and an obesogenic diet prevented the increase in intestinal permeability and metabolic endotoxemia derived to the diet .…”

“…[22] Proanthocyanidin effect on intestinal dysfunction animal models has been poorly studied and mostly in models with high severity. [23] In a previous study by our group, [24] we found that dietary doses of a grape seed extract rich in proanthocyanidins had beneficial effects when they were administered in a corrective way, in a diet-induced obesity model of intestinal dysfunction in rats. Specifically, we demonstrated that these bioactive compounds found in a grape seed proanthocyanidin extract (GSPE) had protective effects on intestinal oxidative stress and from barrier disruption by TJ modulation and prevented intestinal inflammation at dietary doses (5,25, and 50 mg kg -1 body weight [bw]).…”