Chronic thrombosis of bioprostheses: Diagnosis and management

Shahinian, Jasmin H.; Chan, Vincent; Pislaru, Sorin

doi:10.1016/j.pcad.2022.06.008

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Subclinical leaflet thrombosis is diagnosed when imaging findings reveal HALT/RLM or HAM, but without significant deterioration of valve hemodynamics or associated symptoms/sequelae. It is worth noting that subclinical thrombosis may spontaneously resolve without any treatment in up to 50% of cases [15]. Currently, there is no evidence to suggest that subclinical leaflet thrombosis significantly impacts clinical outcomes.…”

Section: Thrombosismentioning

confidence: 99%

Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?

Fazzari,

Baggiano,

Fusini

et al. 2023

JCM

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Biological valve failure (BVF) is an inevitable condition that compromises the durability of biological heart valves (BHVs). It stems from various causes, including rejection, thrombosis, and endocarditis, leading to a critical state of valve dysfunction. Echocardiography, cardiac computed tomography, cardiac magnetic resonance, and nuclear imaging play pivotal roles in the diagnostic multimodality workup of BVF. By providing a comprehensive overview of the pathophysiology of BVF and the diagnostic approaches in different clinical scenarios, this review aims to aid clinicians in their decision-making process. The significance of early detection and appropriate management of BVF cannot be overstated, as these directly impact patients’ prognosis and their overall quality of life. Ensuring timely intervention and tailored treatments will not only improve outcomes but also alleviate the burden of this condition on patients’ life. By prioritizing comprehensive assessments and adopting the latest advancements in diagnostic technology, medical professionals can significantly enhance their ability to manage BVF effectively.

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Section: Thrombosismentioning

confidence: 99%

Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?

Fazzari,

Baggiano,

Fusini

et al. 2023

JCM

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Thrombosis of Bioprosthetic Aortic Valve: Is the Entire Arsenal Deployed?

Loardi,

Zanobini,

Vermes

et al. 2024

Rev. Cardiovasc. Med.

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The proliferation of transcatheter aortic valve implantation has alerted clinicians to a specific type of prosthetic degeneration represented by thrombosis. The pathogenesis of this clinical or subclinical phenomenon, which can occur in up to 15% of both surgical and percutaneous procedures, is poorly understood, as is its potential impact on patient prognosis and long-term bioprosthesis durability. Based on this lack of knowledge about the real meaning and importance of bioprosthetic valve thrombosis, the aim of the present review is to draw the clinicians’ attention to its existence, starting from the description of predisposing factors that may require a closer follow-up in such categories of patients, to an in-depth overview of all available imaging modalities with their respective pros and cons. Finally, a glimpse into the future of technology and biomarker development is presented. The hope is to increase the rate of bioprosthetic diagnosis, especially of the subclinical one, in order to understand (thanks to a strict and prolonged follow-up) if it can only be considered as an incidental tomographic entity without significant clinical consequences, or, on the contrary, if it is associated with neurological events or accelerated bioprosthetic degeneration. Nevertheless, despite the technical advances of echocardiography and cardiac tomography in terms of accurate bioprosthesis thrombosis detection, several diagnostic and therapeutic issues remain unresolved, including possible prevention strategies, tailored treatment protocols, and follow-up modalities.

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Chronic thrombosis of bioprostheses: Diagnosis and management

Cited by 2 publications

References 43 publications

Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?

Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?

Thrombosis of Bioprosthetic Aortic Valve: Is the Entire Arsenal Deployed?

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