Chronic toxicity and endocrine disruption of naproxen in freshwater waterfleas and fish, and steroidogenic alteration using H295R cell assay

Kwak, Kyunghee; Ji, Kyunghee; Kho, Younglim; Kim, Pilje; Lee, Jaean; Ryu, Jisung; Choi, Kyungho

doi:10.1016/j.chemosphere.2018.04.035

Cited by 75 publications

(20 citation statements)

References 32 publications

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“…Several studies reported the effect of NSAIDs in non-target organisms [110,111]. In a study conducted by Xia et al (2017), a significant hatch delay in zebra fish (Danio rerio) due to the suppression of overall embryo motion was observed after an exposure to ibuprofen (500 µg L −1 ) and diclofenac (5 µg L −1 and 500 µg L −1 ) [110].…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective

Fernandes

Almeida

Salgado

et al. 2021

Toxics

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Various contaminants of emerging concern (CECs) have been detected in different ecosystems, posing a threat to living organisms and the environment. Pharmaceuticals are among the many CECs that enter the environment through different pathways, with wastewater treatment plants being the main input of these pollutants. Several technologies for the removal of these pollutants have been developed through the years, but there is still a lack of sustainable technologies suitable for being applied in natural environments. In this regard, solutions based on natural biological processes are attractive for the recovery of contaminated environments. Bioremediation is one of these natural-based solutions and takes advantage of the capacity of microorganisms to degrade different organic pollutants. Degradation of pollutants by native microorganisms is already known to be an important detoxification mechanism that is involved in natural attenuation processes that occur in the environment. Thus, bioremediation technologies based on the selection of natural degrading bacteria seem to be a promising clean-up technology suitable for application in natural environments. In this review, an overview of the occurrence and fate of pharmaceuticals is carried out, in which bioremediation tools are explored for the removal of these pollutants from impacted environments.

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Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective

Fernandes

Almeida

Salgado

et al. 2021

Toxics

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“…At low, environmental concentrations, ibuprofen can imbalance the oxidative status of mussels and provoke the onset of oxidative stress in freshwater invertebrates [59]. Chronic exposure to naproxen can inhibit the reproduction of crustaceans D. magna and M. macrocopa [60] and increase lipid peroxidation in freshwater mussels Elliptio complanata [61].…”

Section: Nsaids Toxicity For Invertebrates and Vertebratesmentioning

confidence: 99%

“…Chronic toxicity of naproxen evaluated on Japanese rice fish (Oryzias latipes) revealed that naproxen in concentrations of 0.5 mg/L significantly decreased the survival of juvenile fish and significantly increased transcription of erβ2 ERβ2 gene [60]. The subchronic exposure to naproxen sodium and naproxen sodium mixture with tramadol hydrochloride had also a strong effect on oxidative stress, hatching, developmental rate, morphology, histopathology, and, in the case of mixture, mortality of common carp (C. carpio) in the early life stages [67].…”

Section: Nsaids Toxicity For Invertebrates and Vertebratesmentioning

confidence: 99%

Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?

et al. 2021

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The non-steroidal anti-inflammatory drugs (NSAIDs) are the most used drugs in knee OA (osteoarthritis) treatment. Despite their efficiency in pain and inflammation alleviation, NSAIDs accumulate in the environment as chemical pollutants and have numerous genetic, morphologic, and functional negative effects on plants and animals. Ultrasound (US) therapy can improve pain, inflammation, and function in knee OA, without impact on environment, and with supplementary metabolic beneficial effects on cartilage compared to NSAIDs. These features recommend US therapy as alternative for NSAIDs use in knee OA treatment.

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“…Considerably more toxicity data are available on S(+)-naproxen (without comparative data for R(−)-naproxen) as it the 'off-the-shelf' standard available (Table 5). This includes chronic toxicity data whereby the lowest NOEC to the crustacean Moina macrocopa (7 days, reproduction) was 0.3 mg L −1 (Kwak et al 2018) (Table 5). Although S(+)-naproxen is the dominant enantiomer in the environment with enantiomeric fractions 0.84-0.98, notable R(−)-naproxen concentrations are also present (Table 4).…”

Section: Enantiospecific Toxicitymentioning

confidence: 99%

Analysis, fate and toxicity of chiral non-steroidal anti-inflammatory drugs in wastewaters and the environment: a review

Petrie

Camacho‐Muñoz

2020

Environ Chem Lett

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Non-steroidal anti-inflammatory drugs (NSAIDs) are found in the aquatic environment globally. Such drugs including naproxen, ibuprofen and ketoprofen are chiral molecules. Enantiomers of those drugs have identical physicochemical properties but can behave and interact differently in chiral environments due to differences in their three-dimensional shape. This results in enantiospecific differences in environmental fate and toxicity, which is often overlooked. Therefore, we review the analytical methods, occurrence and fate, and toxicity of chiral non-steroidal anti-inflammatory drugs at the enantiomeric level. The advancement of enantioselective chromatography methods, particularly the use of polysaccharide-based stationary phases, has enabled trace determination of enantiomers in complex environmental matrices. Macrocosm and microcosm studies of engineered and natural environments revealed that such drugs can undergo both enantioselective degradation and chiral inversion. Enantioselectivity has been reported during wastewater treatment, in surface waters and in agricultural soils. The use of microcosms spiked with individual enantiomers over racemates is essential to evaluate these degradation and inversion fate processes. The chiral inversion process whereby one enantiomer converts into its antipode can be significant if the more toxic enantiomers are formed. Existing enantiospecific effect studies report less than an order of magnitude difference in enantiomer toxicity. However, toxicity data for enantiomers are limited and further research is needed to better appreciate the environmental risk at the enantiomeric level.

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Chronic toxicity and endocrine disruption of naproxen in freshwater waterfleas and fish, and steroidogenic alteration using H295R cell assay

Cited by 75 publications

References 32 publications

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective

Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?

Analysis, fate and toxicity of chiral non-steroidal anti-inflammatory drugs in wastewaters and the environment: a review

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