Chronic Toxicity Evaluation of Majoon-e-Kundur

Abstract

Background: Majoon-e-Kundur (MK) is a compound Unani formulation used in Taqteer-ul-Baul (Dribbling of urine), Salasul-Baul (Urinary incontinence), Baul Filfarash (Nocturnal enuresis), Surat-e-Inzal (Premature ejaculation) and Zof-e-Masana (weakness of urinary bladder). However, toxicity studies on MK have not been carried out for its long-term use .Objective: The present study was carried out to study the 180 days repeated dose toxicity of MK in rats. Materials and methods:The study was carried out on Sprague Dawley (SD) rats of both sexes. Animals were divided into two groups (n = 15). MK was administered at a limit dose of 2000 mg/kg bw/day p.o. for 180 days. After completion of 180 days blood samples were collected for hematological and biochemical analysis and animals were sacrificed, and organs were harvested for relative organ weight determination followed by histopathological evaluation.Results: Animals in groups treated with MK did not show any abnormal behavior or clinical signs indicative of systemic toxicity. There was no toxicologically significant alteration observed in body weight, feed intake, hematological and biochemical parameters, relative organ weights and histopathological findings of control and MK treated rats of either sex. Conclusion:There were no toxicologically significant alterations with respect to clinical signs of toxicity, body weight gain and feed intake, hematology, clinical chemistry, organ weight, gross necropsy and histopathological findings in MK treated rats at a dose of 2000 mg/kg bw as compared to control group. It may be concluded based on the above observations that MK is safe up to the limit dose tested in rats.

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“…Although it is a traditional system of medicine being practiced since centuries, there is negligible documented evidence regarding their safety and effectiveness. However, the need of the time is to validate these medicines as per the current regulatory requirements 4 . The major hypothetical advantage of botanicals over conventional drugs is the presence of multiple active compounds that together can provide a potentiating effect that may not be achievable by any single compound.…”