Chronic toxicity of 50 metals to Ceriodaphnia dubia

Abstract

Metals are essential elements for human life but may cause disorders when exposure is excessive. Previously, we reported on the acute toxicity of 50 metals; however, the chronic toxicity data of some metals are not available. Therefore, we conducted chronic toxicity tests to determine the effects of 50 metals on the water flea, Ceriodaphnia dubia. The IC20 of 20 metals (Be, Sc, Cr, Co, Ni, Cu, Zn, Y, Ru, Ag, Cd, In, Te, W, Os, Pt, Au, Hg, Tl and Pb) were <100 μg/L; nine metals (Al, V, As, Se, Zr, Nb, Rh, Sb and Bi) were 100 ≤ IC20 < 1000 μg/L; 16 metals (Li, Mg, K, Ti, Mn, Fe, Ga, Ge, Rb, Sr, Mo, Sn, Cs, Ba, Re and Ir) were 1000 ≤ IC20 ≤ 100 000 μg/L; and two metals (Na and Ca) were >100 000 μg/L. Three metals (Pd, Hf and Ta) did not show IC20 at the upper limit of respective aqueous solubility, and IC20s were not obtained. The maximum test concentrations (almost aqueous solubility) of Pd, Hf and Ta were 83, 2400 and 5.3 μg/L, respectively. These data show the high correlation between our IC50s for C. dubia and those for Dahpnia magna published previously. The IC50s of 47 metals were not correlated with electronegativity, first ionization energy, atomic weight, atomic number, covalent radius, atomic radius or ionic radius.

Analysis of Novel Schiff Base-Fe Complexes Against Breast Cancer Cells’ Viability

“…The aim of using radiosensitizers is to give a low dose of radiation and subsequently induce a higher dose at the target cancer site while minimizing the effects on other organs at risk. Low doses of radiosensitizers were usually used, obtained from IC20, to minimize the agents' effect and emphasize the radiation effects [3,46,63].…”