Chronic Toxicity, Oncogenic Potential, and Reproductive Toxicity of <i>p</i>-Nitroaniline in Rats

Nair, Rashmi S.; Auletta, Carol; Schroeder, Raymond E.; Johannsen, Frederick R.

doi:10.1093/toxsci/15.3.607

Cited by 15 publications

(9 citation statements)

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“…The primary target of aniline insult in rats appears to be the hemopoietic system, and injury is characterized by methemoglobinemia, hemolysis, and hemolytic anemia (Harrison & Jollow, 1986;Kim & Carlson, 1986;Khan et al, 1993Khan et al, , 1995 and by the development of hyperplasia, siderosis, and a variety of sarcomas of the spleen on prolonged exposure (Bus & Popp, 1987). Many of the characteristics of splenic toxicity in rats such as splenomegaly, hyperplasia, hyperpigmentation, and/or formation of highly malignant tumors (e.g., fibrosarcomas) are not restricted to aniline but also occur when animals are fed with substituted anilines such as o-toluidine (Goodman et al, 1984), chloroaniline (Ward et al, 1980;Chhabra et al, 1990), p-nitroaniline (Nair et al, 1990), 4,4'-sulfonyldianiline (Goodman et al, 1984), D&C red dye no. 9 (Weinberger et al, 1985) and substituted phenylurea herbicides (Wang et al, 1993).…”

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confidence: 99%

Erythrocyte‐aniune interaction leads to their accumulation and iron deposition in rat spleen

Khan

Kaphalia

Ansari

1995

Journal of Toxicology and Environmental Health

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In order to understand the splenic toxicity of aniline in rats, early interaction of aniline with erythrocytes and its subsequent deposition and covalent binding to macromolecules in target (spleen) and nontarget (liver) organs have been studied. Male Sprague-Dawley (SD) rats were given 1 or 3 doses of 1 mmol/kg [14C]aniline hydrochloride (1 dose/d) by gavage and euthanized 24 h after the treatment. Among blood components, maximum radioactivity was found to be associated with red blood cells (RBCs). After 3 doses, there was 112, 79, and 67% increase in the radioactivity in the whole blood, RBCs, and hemolysate, respectively, in comparison to 1 dose. In comparison to RBCs, plasma had only 40 and 16% radioactivity after the administration of 1 and 3 doses, respectively. Spleen homogenate at 1 dose had one-third of the radioactivity in the TCA precipitate, which increased to 40% at 3 doses, while the total radioactivity increased 256% over 1 dose. Liver, which had almost double the radioactivity on a per gram tissue basis compared to the spleen at one dose, did not show any appreciable increase in the radioactivity at three doses. However, radioactivity in the TCA precipitate of liver homogenate increased by 92% after 3 doses. The iron content of the spleen in rats given 3 doses of [14C]aniline increased by 85% compared to the rats given just 1 dose. The iron content of liver did not show any change at three doses. These data thus demonstrate a dose-dependent binding and accumulation of radioactivity in erythrocytes and spleen. These interactions, along with parallel increases in the iron content of the spleen, could be critical in the splenic toxicity of anilines.

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Erythrocyte‐aniune interaction leads to their accumulation and iron deposition in rat spleen

Khan

Kaphalia

Ansari

1995

Journal of Toxicology and Environmental Health

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“…Amines are used for many applications, but their release in the environment needs to be carefully monitored and controlled. Para-nitroaniline (p-NA) is a harmful compound due to its hematoxicity, splenotoxicity, hepatoxicity, and nephrotoxicity: accordingly, its dispersion in water strongly affects human health and represents a huge threat to the environment [1,2,3]. p-NA is resistant to chemical and biological oxidation degradation due to the presence of a nitro group linked to the aromatic ring.…”

Section: Introductionmentioning

confidence: 99%

Polyethersulfone Mats Functionalized with Porphyrin for Removal of Para-nitroaniline from Aqueous Solution

et al. 2019

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The dispersion of para-nitroaniline (p-NA) in water poses a threat to the environment and human health. Therefore, the development of functional adsorbents to remove this harmful compound is crucial to the implementation of wastewater purification strategies, and electrospun mats represent a versatile and cost-effective class of materials that are useful for this application. In the present study, we tested the ability of some polyethersulfone (PES) nanofibers containing adsorbed porphyrin molecules to remove p-NA from water. The functional mats in this study were obtained by two different approaches based on fiber impregnation or doping. In particular, meso-tetraphenyl porphyrin (H2TPP) or zinc(II) meso-tetraphenyl porphyrin (ZnTPP) were immobilized on the surface of PES fiber mats by dip-coating or added to the PES electrospun solution to obtain porphyrin-doped PES mats. The presence of porphyrins on the fiber surfaces was confirmed by UV–Vis spectroscopy, fluorescence measurements, and XPS analysis. p-NA removal from water solutions was spectrophotometrically detected and evaluated.

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“…p-NA has been used as a precursor in various industrial products such as drugs, pesticides, dyes, plastic, explosives, rubber, and epoxy polymers and combustion products [5,6]. It has harmful effects such as genotoxic, allergenic, mutagenic, and carcinogenic on human health [2][3][4]. Various manufacturers of herbicides, pesticides, dyes, and pharmaceuticals industries release toxic effluents consisting of p-NA in it [6].…”

Section: Introductionmentioning

confidence: 99%

Electrooxidation and Kinetic Study of p-Nitroaniline in Acidic Solution

Paliwal¹

2018

IJRASET

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Chronic Toxicity, Oncogenic Potential, and Reproductive Toxicity of p-Nitroaniline in Rats

Cited by 15 publications

References 0 publications

Erythrocyte‐aniune interaction leads to their accumulation and iron deposition in rat spleen

Erythrocyte‐aniune interaction leads to their accumulation and iron deposition in rat spleen

Polyethersulfone Mats Functionalized with Porphyrin for Removal of Para-nitroaniline from Aqueous Solution

Electrooxidation and Kinetic Study of p-Nitroaniline in Acidic Solution

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