Chronic Traumatic Encephalopathy: Advocacy and Communicating with the Public

Uretsky, Madeline; Nowinski, Christopher J.

doi:10.1055/s-0040-1713621

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…This coincides with consensus confirmation of the CTE pathognomonic lesion and publication of the NINDS pathological criteria [ 58 ]. It further correlates with the increase in postmortem brain donations to the VA-BU-CLF brain bank due to increased efforts to promote brain donation by the CLF, including the relaunch of the brain donation campaign and a transition to an online signup system [ 86 ]. Assessment of the 42 tissue studies indicated that the CTE cases were sourced from at least 13 different brain banks.…”

Section: Resultsmentioning

confidence: 99%

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

Murray

Osterman

Bell

et al. 2022

acta neuropathol commun

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Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma and is characterised by the perivascular accumulation of hyperphosphorylated tau (p-tau) in the depths of cortical sulci. CTE can only be diagnosed postmortem and the cellular mechanisms of disease causation remain to be elucidated. Understanding the full scope of the pathological changes currently identified in CTE is necessary to identify areas requiring further research. This systematic review summarises the current literature on CTE pathology from postmortem human tissue histology studies published until 31 December 2021. Publications were included if they quantitively or qualitatively compared postmortem human tissue pathology in CTE to neuropathologically normal cases or other neurodegenerative diseases such as Alzheimer’s disease (AD). Pathological entities investigated included p-tau, beta-amyloid, TDP-43, Lewy bodies, astrogliosis, microgliosis, axonopathy, vascular dysfunction, and cell stress. Of these pathologies, p-tau was the most frequently investigated, with limited reports on other pathological features such as vascular dysfunction, astrogliosis, and microgliosis. Consistent increases in p-tau, TDP-43, microgliosis, axonopathy, and cell stress were reported in CTE cases compared to neuropathologically normal cases. However, there was no clear consensus on how these pathologies compared to AD. The CTE cases used for these studies were predominantly from the VA-BU-CLF brain bank, with American football and boxing as the most frequent sources of repetitive head injury exposure. Overall, this systematic review highlights gaps in the literature and proposes three priorities for future research including: 1. The need for studies of CTE cases with more diverse head injury exposure profiles to understand the consistency of pathology changes between different populations. 2. The need for more studies that compare CTE with normal ageing and AD to further clarify the pathological signature of CTE for diagnostic purposes and to understand the disease process. 3. Further research on non-aggregate pathologies in CTE, such as vascular dysfunction and neuroinflammation. These are some of the least investigated features of CTE pathology despite being implicated in the acute phase response following traumatic head injury.

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Section: Resultsmentioning

confidence: 99%

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

Murray

Osterman

Bell

et al. 2022

acta neuropathol commun

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“…CTE can only be officially diagnosed upon post-mortem analysis. The pathognomonic lesions for this disease are perivascular, hyperphosphorylated tau-immunoreactive neurofibrillary tangles and abnormal neurites distributed at the sulcal depths [ 60 , 61 ]. Though it may not be officially diagnosed while patients are alive, there are clinical characteristics that when paired with a patient’s history, can strongly indicate CTE.…”

Section: Outcomes Of Tbi Due To Domestic Violencementioning

confidence: 99%

“…Though it may not be officially diagnosed while patients are alive, there are clinical characteristics that when paired with a patient’s history, can strongly indicate CTE. CTE is a progressive disease, with most patients not showing symptoms until years or decades after their head injuries [ 59 , 60 ]. Patient with CTE may exhibit childish behavior, including violent and disinhibited outbursts.…”

Section: Outcomes Of Tbi Due To Domestic Violencementioning

confidence: 99%

Update on Domestic Violence and Traumatic Brain Injury: A Narrative Review

Costello

Greenwald

2022

Brain Sciences

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Research on traumatic brain injury (TBI) as a result of domestic violence has greatly increased in the past decade, with publications addressing the prevalence, diagnosis, evaluation, and treatment. Although TBI due to domestic violence has recently been found to occur quite frequently, it was not widely understood until the 1990s. Individuals who suffer from domestic violence TBI often experience sequelae such as decreased cognitive functioning, memory loss, and PTSD. The goal of this article is to increase awareness about TBI secondary to domestic violence, with the intent that it will highlight areas for future research on the diagnosis, evaluation, and treatment of TBI in this population. The articles in this study were first found using the search terms traumatic brain injury and domestic violence. Although, in recent years, there has been a significant increase in research on TBI due to domestic violence, the overall conclusion of this review article is that there is still a need for future research in many areas including the effects on minority populations, the effects of COVID-19, and improvements of screening tools.

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“…In recent decades, there has been an increase in research on sport-associated concussion as a result of neurological symptoms experienced by high-profile and retired athletes, consequently lawsuits with large media coverage have ensued. Studies have linked repeated incidence of concussive events with some neurological conditions such as chronic traumatic encephalopathy (CTE) ( 1 ). This profound link clearly indicates the importance for researchers into the acute and chronic effects of concussion to make participation in sport safer for both professional and amateur/community athletes during their playing careers and beyond.…”

Section: Introductionmentioning

confidence: 99%