Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus

Bhakta, Ami; Gavini, Kartheek; Yang, Euitaek; Lyman-Henley, Lani; Parameshwaran, Kodeeswaran

doi:10.1016/j.bbr.2017.08.013

Cited by 16 publications

(11 citation statements)

References 121 publications

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“… 27 One study found reduced Achl levels in the hippocampus of stressed mice. 28 Another study on mice showed that exercise-induced exhaustion produced decreased GABA and Glu in the subthalamic nucleus extracellular fluid, as expected. 29 However, although we found a negative association between exhaustion and GABA, there was a positive association between exhaustion and Glu.…”

Section: Discussionmentioning

confidence: 54%

Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: a cross-sectional study

Yao

Zhao

Zhang³

et al. 2018

J Int Med Res

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ObjectiveThe aim of the present study was to investigate the relationship between job burnout and neurotransmitter levels in medical staff.MethodsA total of 80 medical staff were enrolled in the study and assessed for occupational burnout using the Maslach Burnout Inventory – General Survey (MBI-GS). The levels of neurotransmitters in the cerebral cortex were analysed using an SP03 encephalofluctuograph.ResultsThe levels of the neurotransmitters γ-aminobutyric acid, 5-hydroxytryptamine (5-HT), norepinephrine (NE), glutamate, acetylcholine (Achl) and dopamine (DA) were significantly lower in men than in women. Medical staff with lower levels of exhaustion had significantly higher neurotransmitter levels than staff with moderate levels of exhaustion. However, there was no significant interaction between sex and exhaustion on neurotransmitter levels. Canonical correlation showed that exhaustion was positively associated with 5-HT and DA, but negatively associated with NE and Achl, regardless of age and sex.ConclusionNeurotransmitter levels in the cerebral cortex were associated with job-related burnout in medical staff. The findings suggest that long-term job-related burnout may lead to behavioural and psychiatric disorders.

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Section: Discussionmentioning

confidence: 54%

Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: a cross-sectional study

Yao

Zhao

Zhang³

et al. 2018

J Int Med Res

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“…Previous studies showed that chronic stress induced obvious neuroinflammation in the brain ( Bhakta et al, 2017 ; Kim and Won, 2017 ). Both the blocking of the inflammatory factor signal and the limiting of microglia activation alleviated chronic stress induced brain dysfunction ( Goshen et al, 2008 ; Liu et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice

Wang

et al. 2018

Front. Behav. Neurosci.

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Mounting evidence shows that chronic stress can affect both the structure and function of the brain resulting in decreased synaptic plasticity and cognitive dysfunction. Although several studies have indicated that aged brains are more vulnerable to chronic stress, it remains unknown how to prevent stress-induced memory deficits in aged animals. Neuroinflammation plays an important role in the pathogenesis of chronic stress-related brain dysfunction. Receptor-interacting protein 1 (RIP1) is a key molecule that can modulate inflammation, apoptosis, and necroptosis. Here, we investigated whether inhibiting RIP1 using necrostatin-1 during chronic stress could improve chronic stress-related brain dysfunction in D-galactose-induced aging mice. The stressed mice underwent restraint stress for 14 days. Necrostatin-1 (6.25 mg/kg) or vehicle was administered intraperitoneally once every 3 days during the stress period. Locomotor activity was tested using the open field test and cognitive function was assessed using the novel object recognition and Barnes maze tests. The hippocampus was collected to assess neuroinflammation (Iba1, IL-1α, IL-1β, TNF-α, and C1q), necroptosis [RIP1, RIP3, mixed lineage kinase domain-like (MLKL), and NF-κB], neuroplasticity (doublecortin, NR1, NR2A, NR2B, GluA1, and GluA2), and the expression of glucocorticoid and mineralocorticoid receptors. Blood samples were collected to quantify the levels of corticosterone. We found that chronic stress induced obvious memory impairment and neuroinflammation, decreased neurogenesis and GluA2 expression, and increased the expression of RIP1 and NF-κB. Inhibiting RIP1 by necrostatin-1 during chronic stress rescued the memory impairment and alleviated the pathological changes induced by stress. These suggest that inhibiting RIP1 using necrostatin-1 improves chronic stress-related brain dysfunction in D-galactose-induced aging mice. The potential mechanisms include limitation of neuroinflammation and the rescue of neurogenesis and GluA2 expression.

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“…In each trial the animal is placed in the central chamber of the maze for habituation and can then freely explore the arms until it consumes all food reward or until a maximum time. The measurement of memory is the number of errors committed, defined as entries in a previously visited arm[ 118 , 119 ]. Chronic stress induced by visual and olfactory exposure to a predator (Long Evan rat) without direct physical contact impairs performance in the radial maze[ 118 ].…”

Section: Behavioral Paradigms To Study Stress-related Psychiatric Disordersmentioning

confidence: 99%

“…The measurement of memory is the number of errors committed, defined as entries in a previously visited arm[ 118 , 119 ]. Chronic stress induced by visual and olfactory exposure to a predator (Long Evan rat) without direct physical contact impairs performance in the radial maze[ 118 ]. Similarly, maternal separation induces an overall impairment in the performance of the radial maze in adulthood; however, this impairment is observed in susceptible, but not in resilient mice[ 119 ].…”

Section: Behavioral Paradigms To Study Stress-related Psychiatric Disordersmentioning

confidence: 99%

Resilience to the effects of social stress on vulnerability to developing drug addiction

Calpe-López¹,

Martínez-Caballero²,

García-Pardo³

et al. 2022

WJP

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We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse. We define the concept of resilience and how it is applied to the field of drug addiction research. We also describe the internal and external protective factors associated with resilience, such as individual behavioral traits and social support. We then explain the physiological response to stress and how it is modulated by resilience factors. In the subsequent section, we describe the animal models commonly used in the study of resilience to social stress, and we focus on the effects of chronic social defeat (SD), a kind of stress induced by repeated experience of defeat in an agonistic encounter, on different animal behaviors (depression- and anxiety-like behavior, cognitive impairment and addiction-like symptoms). We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents. Finally, we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse, describing the current state of knowledge and suggesting future research directions.

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Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus

Cited by 16 publications

References 121 publications

Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: a cross-sectional study

Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: a cross-sectional study

Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice

Resilience to the effects of social stress on vulnerability to developing drug addiction

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