Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human

Pouzet, Bruno; Mow, Tomas; Kreilgård, Mads; Velschow, Sten

doi:10.1016/s0091-3057(03)00042-x

Cited by 131 publications

(118 citation statements)

References 32 publications

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“…In keeping with this, body weight was not affected when haloperidol was administered orally to male rats for three or six weeks (Minet-Ringuet et al, 2005 andPouzet et al, 2003), and was even suppressed under the longer treatment period of 80 weeks (Yoshida et al, 1995). The early stages of obesity, indicated by an increase in percent body fat, have been observed even in the absence of increases in body weight or food intake (Kushi et al, 1998, Pedrazzini et al, 1998and Sainsbury et al, 1997.…”

Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning

confidence: 59%

“…A similar effect on body weight gain was observed in risperidone-treated female mice but without any accompanying increase in food intake (Cope et al, 2005). In contrast to the commonly observed body weight gain in female rodents, haloperidol or risperidone did not induce body weight gain in male rats (Baptista et al, 2002b andPouzet et al, 2003). However, the antipsychotic-induced effect on body weight is dose-sensitive, as another study reported body weight gain in male rats at low but not high doses of risperidone (Ota et al, 2002) and another study showed that female rats receiving a low dose of haloperidol (0.04 mg/kg/day) did not gain weight (Arjona et al, 2004).…”

Section: Introductionmentioning

confidence: 56%

“…In k weight was not affected when halope orally to male rats for three or six et al., 2005;Pouzet et al, 2003), and w der the longer treatment period of 80 1995). The early stages of obesity, in in percent body fat, have been observ of increases in body weight or food 1998; Pedrazzini et al, 1998; Sainsbu due to preferential channelling of f such as muscle and bone towards wh the influence of hormonal changes su levels of insulin (Cusin et al, 1990laume-Gentil et al, 1993 and growt 1996) and reduced serum levels of t et al, 1966), IGF-1 (Shaw et al, 2 (Mudali and Dobs, 2004).…”

Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning

confidence: 92%

“…Haloperidol has been reported to increase body weight in female rats with or without increase in food intake (Fell et al, 2004, Fell et al, 2005and Pouzet et al, 2003. Chronic risperidone treatment lead to increases in both body weight gain and food intake in female rats (Baptista et al, 2002b andPouzet et al, 2003). A similar effect on body weight gain was observed in risperidone-treated female mice but without any accompanying increase in food intake (Cope et al, 2005).…”

Section: Introductionmentioning

confidence: 90%

“…Current literature on the effects of haloperidol and risperidone on body weight gain and food intake vary, which is mostly likely due to the widely different drug treatment designs (dose and duration of drug treatment, mode of administration, diet composition, species and gender of experimental subjects). Haloperidol has been reported to increase body weight in female rats with or without increase in food intake (Fell et al, 2004, Fell et al, 2005and Pouzet et al, 2003. Chronic risperidone treatment lead to increases in both body weight gain and food intake in female rats (Baptista et al, 2002b andPouzet et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats

et al. 2006

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Antipsychotic drugs have been used effectively for the treatment of schizophrenia symptoms, but they are often associated with metabolic side effects such as weight gain and endocrine disruptions. To investigate the possible mechanisms of antipsychotic-induced metabolic effects, we studied the impact of chronic administration of a typical antipsychotic drug (haloperidol) and an atypical antipsychotic (risperidone) to male rats on food intake, body weight, adiposity, and the circulating concentrations of hormones and metabolites that can influence energy homeostasis. Chronic (28 days) haloperidol administration had no effect on food intake, weight gain or adiposity in male rats, whereas risperidone treatment resulted in a transient reduction in food intake and significantly reduced body weight gain compared to vehicle-treated control rats. Whereas neither antipsychotic had any effect on serum lipid profiles, glucose tolerance or the circulating concentrations of hormones controlled by the hypothalamo-pituitary-thyroid (free T4), -adrenal (corticosterone), -somatotropic (IGF-1), orgonadotropic axes (testosterone), haloperidol increased circulating insulin levels and risperidone increased serum glucagon levels. This finding suggests that haloperidol or risperidone induce distinct metabolic effects. Since metabolic disorders such as obesity and type 2 diabetes mellitus represent serious health issues, understanding antipsychotic-induced endocrine and metabolic effects may ultimately allow better control of these side effects.

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Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 56%

Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats

et al. 2006

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Endocrine and testicular changes induced by olanzapine in adult Wistar rats

Bringel

Júnior

Amorim

et al. 2011

J of Applied Toxicology

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Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen-dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.

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Essential Oil from Citrus aurantifolia prevents ketotifen‐induced weight‐gain in mice

Asnaashari

Delazar

Habibi

et al. 2010

Phytotherapy Research

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Obesity is a major health problem world-wide. Medical intervention is often needed to tackle this problem, and accordingly the need for developing more effective, safer and cheaper weight reducing drugs has become paramount in recent years. In the present study, the effects of lime (Citrus aurantifolia) essential oils in reducing body weight, individually and in co-administration with ketotifen, an antihistaminic drug that causes weight gain, has been investigated using a mouse model. During the 45 days experimental period, the mice that received ketotifen demonstrated an enhancement both in the amount of food intake and body weight compared with the control group. Groups treated with lime essential oil displayed a reduction in body weight and food consumption in mice, possibly through promoting anorexia which might have played a role in weight loss. Interestingly, co-administration of the lime essential oil and ketotifen caused significant suppression in gaining weight, as well as decreased body weights of mice. The data obtained in this study suggested that lime essential oil plays an important role in weight loss and could be useful in the treatment of drug-induced obesity and related diseases. The GC-MS analysis of the essential oils of C. aurantifolia was also performed and approximately 22 main components, with limonene (28.27%) being the principal one, were identified and quantified.

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Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human

Cited by 131 publications

References 32 publications

Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats

Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats

Endocrine and testicular changes induced by olanzapine in adult Wistar rats

Essential Oil from Citrus aurantifolia prevents ketotifen‐induced weight‐gain in mice

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