1987
DOI: 10.1016/0304-3940(87)90633-1
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Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo

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Cited by 100 publications
(44 citation statements)
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“…Overall, it is difficult to compare studies, as different types of voltammetry were used as well as doses of clozapine. Interestingly, both Blaha and Lane (1987) and Lane et al (1988) support the electrophysiological findings, in that chronic CLOZ treatment markedly decreased DA levels in the nucleus accumbens, while striatal DA levels were not altered. Furthermore, this decrease in DA levels in the nucleus accumbens was reversed by i.v.…”
Section: Measurement Of Da and Its Metabolites Using In Vivo Voltammetrysupporting
confidence: 71%
“…Overall, it is difficult to compare studies, as different types of voltammetry were used as well as doses of clozapine. Interestingly, both Blaha and Lane (1987) and Lane et al (1988) support the electrophysiological findings, in that chronic CLOZ treatment markedly decreased DA levels in the nucleus accumbens, while striatal DA levels were not altered. Furthermore, this decrease in DA levels in the nucleus accumbens was reversed by i.v.…”
Section: Measurement Of Da and Its Metabolites Using In Vivo Voltammetrysupporting
confidence: 71%
“…After chronic APD treatments, reduction between 36 and 50% in basal and depolarization-induced extracellular concentrations of dopamine have been observed in the terminal field of DA mesolimbic neurons (44)(45)(46)(47)(48).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, correlates of depolarization block have been described in behavioral (Rompre and Wise, 1989;Doherty and Gratton, 1991) and biochemical (Deutch and Roth, 1988;Finlay et al, 1987;Blaha and Lane, 1987;Chen et aI., 1991) studies of neuroleptic action.…”
Section: Systems Involved In the Induction Of Depolarization Blockmentioning
confidence: 98%
“…Investigators have consistently shown that acute administration of classical antipsychotic drugs results in an increase in extracellular DA levels Zetterstrom et al, 1984;Imperato and DiChiara, 1985), whereas repeated administration of these drugs decreases DA levels in the striatum and accumbens Ichikawa and Meltzer, 1991;Finlay et al, 1987). In contrast, repeated treatment with atypical neuroleptics does not alter DA levels in the striatum (Ichikawa and Meltzer, 1991;Blaha and Lane, 1987;Chen et al, 1991;Invernizzi et al, 1990). The effects reported for chronic clozapine administration on DA levels in the accumbens, on the other hand, are not as consistent, in that studies employing voltammetry report a decrease in DA levels (Chen et al, 1991;Blaha and Lane, 1987), whereas studies employing microdialysis find no change in DA levels (Ichikawa and Meltzer, 1991;Invernizzi et al, 1990).…”
Section: Systems Involved In the Induction Of Depolarization Blockmentioning
confidence: 99%