Chronic treatment with repetitive transcranial magnetic stimulation inhibits seizure induction by electroconvulsive shock in rats

Fleischmann, Amos; Hirschmann, Shmuel; Dolberg, Ornah T.; Dannon, Pinhas N.; Grunhaus, Leon

doi:10.1016/s0006-3223(98)00211-x

Cited by 43 publications

(22 citation statements)

References 16 publications

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“…However, studies of rTMS in epileptic patients do not support this idea, possibly because of anticonvulsant therapy (Wassermann, 1998), and there is even evidence for an anticonvulsive effect of rTMS (Ebert and Ziemann, 1999;Fleischmann et al, 1999). Although Digitimer Ltd. (2002) advises against TES with epilepsy, this is not always considered a contraindication (Burke, personal communication).…”

Section: Safety Of Tes Mep Monitoringmentioning

confidence: 99%

Safety of Intraoperative Transcranial Electrical Stimulation Motor Evoked Potential Monitoring

MacDonald¹

2002

Journal of Clinical Neurophysiology

310

130

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Section: Safety Of Tes Mep Monitoringmentioning

confidence: 99%

Safety of Intraoperative Transcranial Electrical Stimulation Motor Evoked Potential Monitoring

MacDonald¹

2002

Journal of Clinical Neurophysiology

310

130

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“…This anticonvulsant effect was seen only with 25-Hz stimulation, and not with 1-or 5-Hz stimulation. Chronic stimulation twice daily for 16 days made these anticonvulsant effects more marked and long lasting, up to 5 days [Fleischmann et al, 1999]. Other measures of neuronal excitability have demonstrated even more prolonged effects of rTMS.…”

Section: Proconvulsant and Anticonvulsant Effectsmentioning

confidence: 99%

Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): Comparisons with electroconvulsive shock (ECS)

Lisanby

Belmaker

2000

Depress. Anxiety

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Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive means of brain stimulation with a broad range of basic neuroscience and potential future clinical applications. Recent animal studies have shed some light on the mechanisms of action of rTMS, and broadened our understanding of how this intervention affects brain functioning acutely and chronically. Differences in the physical properties of magnetic and electrical stimulation result in marked disparities in the amount and distribution of electrical current induced in the brain; nevertheless, rTMS shares many of the behavioral and biochemical actions of electroconvulsive shock (ECS) and other antidepressant treatments. rTMS reduces immobility in the Porsolt swim task and enhances apomorphine‐induced stereotypy, as does ECS. Although rTMS can induce a seizure when given at high enough doses, most studies have found subconvulsive levels of rTMS to be anticonvulsant. rTMS acutely modulates dopamine and serotonin content and turnover rates. Chronic rTMS modulates cortical β‐adrenergic receptors, reduces frontal cortex 5‐HT2 receptors, increases 5‐hydroxytryptamine1A receptors in frontal cortex and cingulate, and increases N‐methyl‐D‐aspartate receptors in the ventromedial hypothalamus, basolateral amygdala, and parietal cortex. More work will be needed to clarify and explore the mechanism behind the early suggestions that rTMS may exert long‐term‐potentiation‐like or long‐term‐depression‐like action on hippocampal activity. Finally, rTMS is emerging as yet another intervention, like ECS and other antidepressants, that can regulate gene expression and may have an impact on neuronal viability and synaptic plasticity. Depression and Anxiety 12:178–187, 2000. © 2000 Wiley‐Liss, Inc.

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“…A EMTr pode modificar o processamento cortical, sensorial, motor ou cognitivo (Pascual-Leone e cols., 1998; Ziemann e cols., 1998), podendo promover disfunções temporárias em diferentes áreas corticais; por exemplo, a estimulação temporal e frontal inferior podem levar a afasia transitória (Fregni, 2001). O efeito da EMTr sobre o desempenho de diferentes tarefas tornou esta técnica uma importante ferramenta na investigação do papel fisiológico de diferentes áreas cerebrais.…”

Section: Efeitos Neurobiológicos Da Emtrunclassified

Estimulação magnética transcraniana de repetição associada a antidepressivo: início e intensidade da resposta antidepressiva

Rumi¹,

Ortiz²,

Marcolin³

2004

Rev. psiquiatr. clín.

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ResumoObjetivos: Avaliar diferentes estudos que analisam o grau de eficácia da resposta antidepressiva entre a associação de estimulação magnética transcraniana de repetição (EMTr) com antidepressivos em pacientes deprimidos graves. Métodos: Os autores revisaram vários estudos em que a EMTr foi usada concomitantemente a antidepressivos em pacientes deprimidos graves. Adicionalmente, relatou-se um estudo feito no Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Estudo duplo-cego, randomizado, unicêntrico, placebo-controlado com 46 pacientes atendendo aos critérios diagnósticos da DSM-IV para episódio depressivo severo. Os pacientes estavam em uso de amitriptilina. Resultados: De forma geral, a maioria dos estudos mostra que a EMTr apresenta boa eficácia antidepressiva quando associada a antidepressivos. Há grande diversidade de parâmetros técnicos utilizados, tipos de bobina, diferentes técnicas de placebo e uso de diferentes antidepressivos. O estudo realizado no Instituto de Psiquiatria mostrou que o emprego da EMTr de alta freqüência aumentou a resposta antidepressiva à amitriptilina e diminuiu o tempo para o início da resposta antidepressiva em relação ao grupo placebo. Conclusões: EMTr é um método novo, promissor e com grande potencial para o tratamento da depressão. Apesar disso, observa-se que não há ainda uniformidade no emprego dos parâmetros técnicos, nem tampouco das técnicas de placebo. O estudo realizado no Instituto de Psiquiatria do HC-FMUSP mostrou grandes taxas de resposta e remissão em relação ao grupo com estimulação sham e amitriptilna.

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Chronic treatment with repetitive transcranial magnetic stimulation inhibits seizure induction by electroconvulsive shock in rats

Cited by 43 publications

References 16 publications

Safety of Intraoperative Transcranial Electrical Stimulation Motor Evoked Potential Monitoring

Safety of Intraoperative Transcranial Electrical Stimulation Motor Evoked Potential Monitoring

Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): Comparisons with electroconvulsive shock (ECS)

Estimulação magnética transcraniana de repetição associada a antidepressivo: início e intensidade da resposta antidepressiva

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