Chronic Ultraviolet Irradiation to the Skin Dysregulates Adrenal Medulla and Dopamine Metabolism In Vivo

Lim, Hye Sun; Yoon, Kyeong No; Chung, Jin Ho; Lee, Yong Seok; Lee, Dong Hun; Park, Gunhyuk

doi:10.3390/antiox10060920

Cited by 6 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice were anesthetized using a respiratory anesthetic (Hana Pharm Co., Ltd., Seoul, Republic of Korea) and subjected to UV irradiation lamps (VL-6MC, Vilber Lourmat, Collégien, France) emitting 312 nm UVB. The UVB dosage was established according to previous studies [ 23 , 24 ], set at 200 mJ/cm 2 ( Figure 1 B,C). All mice, except those in the control group, were irradiated with UVB once daily for a total of three days before sacrifice.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Red Light-Emitting Diode against UV-B Radiation-Induced Skin Damage in SKH:HR-2 Hairless Mice

Cho,

Ahn,

Shin

et al. 2024

CIMB

View full text Add to dashboard Cite

In this in vivo study on hairless mice, we examined the effects of light-emitting diode (LED) treatment applied prior to ultraviolet B (UVB) irradiation. We found that pre-treating with LED improved skin morphological and histopathological conditions compared to those only exposed to UVB irradiation. In our study, histological evaluation of collagen and elastic fibers after LED treatment prior to UVB irradiation showed that this pretreatment significantly enhanced the quality of fibers, which were otherwise poor in density and irregularly arranged due to UV exposure alone. This suggests that LED treatment promotes collagen and elastin production, leading to improved skin properties. Additionally, we observed an increase in Claudin-1 expression and a reduction in nuclear factor-erythroid 2-related factor 2 (Nrf-2) and heme-oxygenase 1 (HO-1) expression within the LED-treated skin tissues, suggesting that LED therapy may modulate key skin barrier proteins and oxidative stress markers. These results demonstrate that pretreatment with LED light can enhance the skin’s resistance to UVB-induced damage by modulating gene regulation associated with skin protection. Further investigations are needed to explore the broader biological effects of LED therapy on other tissues such as blood vessels. This study underscores the potential of LED therapy as a non-invasive approach to enhance skin repair and counteract the effects of photoaging caused by UV exposure.

show abstract

Section: Methodsmentioning

confidence: 99%

Protective Effect of Red Light-Emitting Diode against UV-B Radiation-Induced Skin Damage in SKH:HR-2 Hairless Mice

Cho,

Ahn,

Shin

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…This may be one mechanism by which sun exposure in people with SLE causes acute exacerbation of nephritis (inflammation of the kidney). In another study in mice, chronic exposure of the skin to broadband UV-B radiation (100–300 m J cm −2 for 3 days per week for 10 weeks) significantly reduced levels of dopamine and related enzymes (tyrosine hydroxylase and dopamine beta-hydroxylase) in the blood and adrenal glands and induced marked damage in the adrenal medulla [ 31 ]. These studies add to our emerging understanding of wide-ranging systemic effects of exposing the skin to UV radiation, noting that studies in mice do not always translate to humans but that similar studies in humans may not be feasible.…”

Section: New Knowledge About Mechanisms Underpinning the Effects Of U...mentioning

confidence: 99%

The effects of exposure to solar radiation on human health

Neale

Lucas

Byrne

et al. 2023

Photochem Photobiol Sci

View full text Add to dashboard Cite

This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts. Of particular note, there is new information about the way in which exposure to UV radiation modulates the immune system, causing both harms and benefits for health. The burden of skin cancer remains high, with many lives lost to melanoma and many more people treated for keratinocyte cancer, but it has been estimated that the Montreal Protocol will prevent 11 million cases of melanoma and 432 million cases of keratinocyte cancer that would otherwise have occurred in the United States in people born between 1890 and 2100. While the incidence of skin cancer continues to rise, rates have stabilised in younger populations in some countries. Mortality has also plateaued, partly due to the use of systemic therapies for advanced disease. However, these therapies are very expensive, contributing to the extremely high economic burden of skin cancer, and emphasising the importance and comparative cost-effectiveness of prevention. Photodermatoses, inflammatory skin conditions induced by exposure to UV radiation, can have a marked detrimental impact on the quality of life of sufferers. More information is emerging about their potential link with commonly used drugs, particularly anti-hypertensives. The eyes are also harmed by over-exposure to UV radiation. The incidence of cataract and pterygium is continuing to rise, and there is now evidence of a link between intraocular melanoma and sun exposure. It has been estimated that the Montreal Protocol will prevent 63 million cases of cataract that would otherwise have occurred in the United States in people born between 1890 and 2100. Despite the clearly established harms, exposure to UV radiation also has benefits for human health. While the best recognised benefit is production of vitamin D, beneficial effects mediated by factors other than vitamin D are emerging. For both sun exposure and vitamin D, there is increasingly convincing evidence of a positive role in diseases related to immune function, including both autoimmune diseases and infection. With its influence on the intensity of UV radiation and global warming, the Montreal Protocol has, and will have, both direct and indirect effects on human health, potentially changing the balance of the risks and benefits of spending time outdoors. Graphical abstract

show abstract

“…Neurotransmitters are crucial neuronal mediators involved in brain aging and disorders such as Parkinson's Disease and Alzheimer's disease 11 . Both the skin and neuroendocrine systems produce neurotransmitters under stimulating conditions 10,[12][13][14] . Furthermore, neurotransmitters produced by the skin might influence specific brain areas that constitute the skin-brain axis 15 .…”

Section: Introductionmentioning

confidence: 99%

Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway

Yoon,

Kim,

et al. 2024

Exp Mol Med

Self Cite

View full text Add to dashboard Cite

The effects of ultraviolet (UV) radiation on brain function have previously been investigated; however, the specific neurotransmitter-mediated mechanisms responsible for UV radiation-induced neurobehavioral changes remain elusive. In this study, we aimed to explore the mechanisms underlying UV radiation-induced neurobehavioral changes. In a mouse model, we observed that UV irradiation of the skin induces deficits in hippocampal memory, synaptic plasticity, and adult neurogenesis, as well as increased dopamine levels in the skin, adrenal glands, and brain. Chronic UV exposure altered the expression of genes involved in dopaminergic neuron differentiation. Furthermore, chronic peripheral dopamine treatments resulted in memory deficits. Systemic administration of a dopamine D1/D5 receptor antagonist reversed changes in memory, synaptic plasticity, adult neurogenesis, and gene expression in UV-irradiated mice. Our findings provide converging evidence that chronic UV exposure alters dopamine levels in the central nervous system and peripheral organs, including the skin, which may underlie the observed neurobehavioral shifts, such as hippocampal memory deficits and impaired neurogenesis. This study underscores the importance of protection from UV exposure and introduces the potential of pharmacological approaches targeting dopamine receptors to counteract the adverse neurological impacts of UV exposure.

show abstract

Chronic Ultraviolet Irradiation to the Skin Dysregulates Adrenal Medulla and Dopamine Metabolism In Vivo

Cited by 6 publications

References 19 publications

Protective Effect of Red Light-Emitting Diode against UV-B Radiation-Induced Skin Damage in SKH:HR-2 Hairless Mice

Protective Effect of Red Light-Emitting Diode against UV-B Radiation-Induced Skin Damage in SKH:HR-2 Hairless Mice

The effects of exposure to solar radiation on human health

Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway

Contact Info

Product

Resources

About