Chronic Unilateral Hearing Loss Disrupts Neural Tuning to Sound-Source Azimuth in the Rat Primary Auditory Cortex

Wang, Xiuwen; Liu, Jing; Zhang, Ji Ping

doi:10.3389/fnins.2019.00477

Cited by 10 publications

(17 citation statements)

References 43 publications

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“…This finding corroborates evidence that asymmetric hearing in early life promotes enhanced representation of the better (or only) hearing ear in the auditory cortices (for review, Gordon and Kral 2019) 13 . Strengthened cortical responses to the better hearing ear have been observed in animal models with conductive hearing loss 18,19 and profound sensory/neural hearing loss 20,43 . Abnormal preference for the better hearing ear also develops in young children with asymmetric hearing and is more difficult to reverse as the duration of CI ear averaged daily CI use (hours) Temporal change of CL C Figure 5.…”

Section: Aural Preference: Auditory Cortex Ipsilateral To Nh Earmentioning

confidence: 99%

“…These findings are consistent with evidence from animals with experimentally induced hearing loss in one ear at different ages. Strengthened responses in the ipsilateral cortex from the intact ear have been found in both juvenile-onset and adult-onset SSD, though the effect size reduces with age 18,19,21 . Similarly, in both adults and children with SSD, imaging studies demonstrate increased ipsilateral cortical responses to the intact ear 17,[23][24][25][26] .…”

Section: Aural Preference: Auditory Cortex Ipsilateral To Nh Earmentioning

confidence: 99%

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Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Lee

Smieja

Polonenko

et al. 2020

Sci Rep

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Potentially neuroprotective effects of CI use were studied in 22 children with single sided deafness (SSD). Auditory-evoked EEG confirmed strengthened representation of the intact ear in the ipsilateral auditory cortex at initial CI activation in children with early-onset SSD (n = 15) and late-onset SSD occurring suddenly in later childhood/adolescence (n = 7). In early-onset SSD, representation of the hearing ear decreased with chronic CI experience and expected lateralization to the contralateral auditory cortex from the CI increased with longer daily CI use. In late-onset SSD, abnormally high activity from the intact ear in the ipsilateral cortex reduced, but responses from the deaf ear weakened despite CI use. Results suggest that: (1) cortical reorganization driven by unilateral hearing can occur throughout childhood; (2) chronic and consistent CI use can partially reverse these effects; and (3) CI use may not protect children with late-onset SSD from ongoing deterioration of pathways from the deaf ear.

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Section: Aural Preference: Auditory Cortex Ipsilateral To Nh Earmentioning

confidence: 99%

Section: Aural Preference: Auditory Cortex Ipsilateral To Nh Earmentioning

confidence: 99%

Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Lee

Smieja

Polonenko

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…That A1 neurons also show location-tuning is more surprising, because A1 activity has hitherto not been associated with animal location. However, in many mammals this area is required for sound localization (Heffner, 1978;Jenkins and Merzenich, 1984;Kavanagh and Kelly, 1987;Thompson and Cortez, 1983) and contains neurons tuned to the location of sound sources (Middlebrooks and Pettigrew, 1981;Town et al, 2017;Wang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Coherent mapping of position and head direction across auditory and visual cortex

Mertens

Marchesi

Lohuis

et al. 2021

Preprint

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Neurons in primary visual cortex (V1) may not only signal current visual input but also relevant contextual information such as reward expectancy and the subject's spatial position. Such location-specific representations need not be restricted to V1 but could participate in a coherent mapping throughout sensory cortices. Here we show that spiking activity in primary auditory cortex (A1) and lateral, secondary visual cortex (V2L) of freely moving rats coherently represents a location-specific mapping in a sensory detection task performed on a figure-8 maze. Single-unit activity of both areas showed extensive similarities in terms of spatial distribution, reliability and position coding. Importantly, reconstructions of subject position on the basis of spiking activity displayed decoding errors that were correlated between areas in magnitude and direction. In addition to position, we found that head direction, but not locomotor speed or head angular velocity, was an important determinant of activity in A1 and V2L. Finally, pairs of units within and across areas showed significant correlations in instantaneous variability of firing rates (noise correlations). These were dependent on the spatial tuning of cells as well as the spatial position of the animal. We conclude that sensory cortices participate in coherent, multimodal representations of the subject's sensory-specific location. These may provide a common reference frame for distributed cortical sensory and motor processes and may support crossmodal predictive processing.

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“…This deprivation reduces the local information processing capacity of auditory and attention networks. Interestingly, UHL can disrupt neural tuning to localize sound in the rat primary auditory cortex (Wang et al, 2019). This may partly explain the finding that, despite improvements on sound localization tests, the localization abilities of children fitted with bone conductive devices for congenital conductive UHL were lower than the localization abilities of children with normal hearing (Nelissen et al, 2016).…”

Section: Impact Of Congenital Uchl On Brain Networkmentioning

confidence: 99%

Poor speech recognition, sound localization and reorganization of brain activity in children with unilateral microtia-atresia

Liu

Wang

Yang

et al. 2021

Brain Imaging and Behavior

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Microtia-atresia is a congenital malformation of the external ear, often affecting one side and being associated with severe-to-profound unilateral conductive hearing loss (UCHL). Although the impact of unilateral hearing loss (UHL) on speech recognition, sound localization and brain plasticity has been intensively investigated, less is known about the subjects with unilateral microtia-atresia (UMA). Considering these UMA subjects have hearing loss from birth, we hypothesize it has a great effect on brain organization. A questionnaire on speech recognition and spatial listening ability was administered to 40 subjects with UMA and 40 age- and sex-matched controls. UMA subjects showed poorer speech recognition in laboratory and poorer spatial listening ability. However, cognitive scores determined by the Montreal Cognitive Assessment (MoCA) and Wechsler Intelligence Scale for Children (WISC-IV) did not differ significantly in these two groups. The impact of hearing loss in UMA on brain functional organization was examined by comparing resting-state fMRIs (rs-fMRI) in 27 subjects with right-sided UMA and 27 matched controls. UMA subjects had increased nodal betweenness in visual networks and DMN but decreases in auditory and attention networks. These results indicate that UCHL in UMA causes significant abnormalities in brain organization. The impact of UCHL on cognition should be further examined with a battery of tests that are more challenging and better focused on the cognitive networks identified.

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Chronic Unilateral Hearing Loss Disrupts Neural Tuning to Sound-Source Azimuth in the Rat Primary Auditory Cortex

Cited by 10 publications

References 43 publications

Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Coherent mapping of position and head direction across auditory and visual cortex

Poor speech recognition, sound localization and reorganization of brain activity in children with unilateral microtia-atresia

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