Chronic unpredictable stress shifts rat behavior from exploration to exploitation

Matisz, Chelsea E.; Badenhorst, Cecilia A.; Gruber, Aaron J.

doi:10.1080/10253890.2021.1947235

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…Stress increased the locomotor activity in OFT and produced anxiogenic and depressogenic effects evident by reduced time spent in enlighten box (LDT) and struggling time in FST. Stressful conditions induce hyperactivity in response to open field novelty and mild threats has been previously reported (Sequeira-Cordero et al, 2019;Matisz et al, 2021). Anxiogenic and depressive symptoms following chronic unpredictable stress are also reported previously (Qiao et al, 2020).…”

Section: Discussionmentioning

confidence: 56%

“…Neurological disorders have shown high prevalence and contributed to an increase in the burden on healthcare costs worldwide (Feigin et al, 2021). Neurological variations which includes anxious and depression-like behaviour with cognitive deficits are the most broadly defined effects of persistent exposure to stress (Matisz et al, 2021). Chronic stress reported to cause increase in oxidative stress which ultimately impairs neurogenesis and induce depressive symptoms in rodents (Sugama & Kakinuma, 2020Blossom et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2023

Pak. J. Pharm. Sci.,

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Repeated episodes of stress results in the development of neuropsychiatric symptoms associated with severe depression. Synthetic antipsychotic medication helps people experiencing the stress induced behavioral problems . These medications have serious side effects. A variety of natural herbs and their extracts are frequently used to treat neurological disorders. Camellia oleifera Abel. oil is used for treatment of metabolic and endocrine problems. Moclobemide is monoamine oxidase inhibitor, widely prescribed for the treatment of depression and anxiety. This study evaluate the neuroprotective effects of camellia oil and moclobemide in animal model of learned helplessness. Stress produced behavioral deficits, increases plasma corticosterone levels , brain lipid peroxidation and decreases the levels of endogenous antioxidant enzymes. Camellia oil pre-treated rats improved behavioral activities, as well as significant reduction in plasma corticosterone and lipid peroxidation, along with rise in activity of antioxidant enzymes. Enhanced level of brain dopamine, dihydroxyphenlyacetic acid and decreased dopamine turnover was also observed in stressed rats. These stress induced changes can be prevented in rats pre-treatment with camellia oil. However, when compared with synthetic antidepressant moclobemide, the rats treated with camellia oil exhibited more promising result.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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“…Previous research has verified that the procedures used to induce CUMS in rats not only lead to depression-like emotions and behaviors but also accurately simulate the pathological process of depression in a rat model [ 42 , 50 ]. In our study, we aimed to validate this CUMS model and further investigate the potential mechanisms of the antidepressant effect of EA in the PFC and liver.…”

Section: Discussionmentioning

confidence: 99%

“…Eighty SD rats in the model group were housed in 80 cages. They were exposed to one of 7 mild stressors daily in a random sequence for 5 weeks [ 42 ]. The following stressors were used in the experiment ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

et al. 2023

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Depression is a complex clinical disorder associated with poor outcomes. Electroacupuncture (EA) has been demonstrated to have an important role in both clinical and pre-clinical depression investigations. Evidence has suggested that the P2X7 receptor (P2X7R), NLRP3, and IL-1β play an important role in depressive disorder. Our study is aimed at exploring the role of EA in alleviating depression-like behaviors in rats. We therefore investigated the effects of EA on the prefrontal cortex and liver of rats subjected to chronic unpredictable mild stress (CUMS) through behavior tests, transmission electron microscopy, Nissl staining, HE staining, immunohistochemistry and Western blotting. Five weeks after exposure to CUMS, Sprague-Dawley (SD) rats showed depression-like behavior. Three weeks after treatment with brilliant blue G (BBG) or EA, depressive symptoms were significantly improved. Liver cells and microglia showed regular morphology and orderly arrangement in the BBG and EA groups compared with the CUMS group. Here we show that EA downregulated P2X7R/NLRP3/IL-1β expression and relieved depression-like behavior. In summary, our findings demonstrated the efficacy of EA in alleviating depression-like behaviors induced by CUMS in rats. This suggests that EA may serve as an adjunctive therapy in clinical practice, and that P2X7R may be a promising target for EA intervention on the liver–brain axis in treatment of depression.

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“…High levels of anxiety correlates to higher neuronal activity in the amygdala (Davis et al, 1994;Sehlmeyer et al, 2011) which influences both the flexibility to act and impulse control, which may lead to exaggerated responses and the inability to adjust one's behavioral course (Moustafa et al, 2017). Conversely, chronic exposure to low levels of stress may lead to a habituation of (mild) risk-avoiding behavior (Charpentier et al, 2016;Matisz et al, 2021). So, it is clear that in a given situation, people choose different options.…”

Section: Neuro-immunological Effective Processesmentioning

confidence: 99%

Action-Shapers and Their Neuro-Immunological Foundations

Paans¹,

Ehlen²

2022

Front. Psychol.

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Not all our intentions translate into actions, as our capacity to act may be influenced by a variety of mental and biochemical factors. In this article, we present a comprehensive account of how neuro-immunological processes affect our intentional abilities and our capacity to act. We do so by extending the theory of thought-shapers (TTS) through the notion of action-shapers and combining this theory with the essential embodiment thesis (EE). This thesis about the mind-body relation says that human minds are necessarily and completely embodied. Action-shapers dynamically constitute the action-space of individuals, affecting their capacity to take action or to select one course of action over another. We highlight the effects and interactions of neuro-immunological effective processes in the body to demonstrate how they shape the action-space. In this article, we consider neuro-immunological effective processes that influence the gut-brain axis, chronic stress, high levels of sugar intake, the amygdala and the effects of prolonged stress. We investigate the effects of these processes on the perception and on the capacity to form intentions and act on them. We conclude the paper by providing a concise account of action-shapers, in which we attempt to summarize the line of argumentation and provide suggestions for further research.

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Chronic unpredictable stress shifts rat behavior from exploration to exploitation

Cited by 13 publications

References 40 publications

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Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

Action-Shapers and Their Neuro-Immunological Foundations

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