Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine

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doi:10.12891/ceog3157.2016

Cited by 2 publications

(1 citation statement)

References 8 publications

(8 reference statements)

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“…One teenager had such severe constipation that in the last 6 years she never had a bowel movement any sooner than 9 days apart and frequently went 6-9 weeks without one. She has had one bowel movement for multiple years now as long as she takes the amphetamine [71]. We recently published another case of severe constipation ameliorated by amphetamine, but the purpose was to show that one does not necessarily have to have pelvic pain to have uterine implantation defects but may be associated with other manifestations of the increased cellular permeability syndrome e.g., constipation.…”

Section: Dopaminergic Drugs To Treat Medical Conditions That Are More...mentioning

confidence: 99%

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

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2024

J Biomed Res Environ Sci

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Based on a conglomeration of basic science research studies a model of hypothetical mechanisms of how the fetal semi-allograft can develop into a live baby was created. One of the tenets of the model is that it is necessary to remodel some of the typically thick-walled uterine arteries found during the proliferative phase into thin-walled spiral arteries to allow nutrient exchange between mother and fetus through an autoimmune mechanism during the luteal phase. The model suggests that the rise in progesterone inhibits dopamine. One function of dopamine is to diminish cellular permeability allowing irritants to infuse into the endometrium thus evoking an inflammatory reaction. The body must suppress these cellular immune cells from attacking the fetus. Progesterone activates membrane progesterone receptors which produces immunomodulatory proteins e.g., the Progesterone Induced Blocking Factor (PIBF), which negates the killing effect of cellular immunity. One hypothesis suggested that PIBF may be secreted by malignant tumors facilitating these tumors with foreign antigens to escape immunosurveillance and thus metastasize. Progesterone receptor antagonists e.g., mifepristone, which suppresses PIBF, have successfully increased length and quality of life in patients with a large variety of end stage treatment resistant cancers. Excessive permeability of various tissues was hypothesized to be related to possible relative deficiency of dopamine. A large variety of medical conditions have been ameliorated significantly by the use of dopaminergic drugs e.g. dextroamphetamine or cabergoline. The model explains why certain conditions may get worse premenstrually e.g., pelvic pain or headaches by the added suppressive effect of progesterone on dopamine. Though possibly further research may modify this model, based on the present hypothesis, a large number of treatment refractory conditions had very successful improvement based on treating with drug releasing dopamine thus correcting tissue permeability disorders.

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Section: Dopaminergic Drugs To Treat Medical Conditions That Are More...mentioning

confidence: 99%

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

H Check*

2024

J Biomed Res Environ Sci

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Pain Sensitivity in Schizophrenia Spectrum Disorders: A Narrative Review of Recent Work

González-Rodríguez

Labad

Seeman

2021

Psychiatry International

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Many patients with schizophrenia seem relatively immune to physical pain while others complain of constant pain. This may result from disturbances or alterations of the sensory threshold for pain in populations with psychosis, a possibility for which there is some preliminary evidence. The inconsistency in pain perception may, in part, be explained by the treatments patients receive, but treatment-naïve patients also exhibit differences in response to pain. This suggests that decreased pain sensitivity may represent a specific psychosis endophenotype. Thus far, few experimental studies have investigated sensory thresholds, pain modalities, or other factors contributing to the perception or expression of physical pain in psychosis. A digital search for information on this topic was conducted in PubMed and Google Scholar. The result is a non-systematic, narrative review focusing on recent clinical and experimental findings of pain sensitivity in patients with psychosis. Importantly, physical and mental pain are closely connected constructs that may be difficult to differentiate. Our hope is that the review provides some clarity to the field in the specific context of schizophrenia.

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Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine

Cited by 2 publications

References 8 publications

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Pain Sensitivity in Schizophrenia Spectrum Disorders: A Narrative Review of Recent Work

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