Chronic urticaria and associated coeliac disease in children: A case–control study

Caminiti, Lucia; Passalacqua, G.; Magazzù, Giuseppe; Comisi, Fabrizio; Vita, Daniela De; Barberio, G; Sferlazzas, Concetta; Pajno, G.B.

doi:10.1111/j.1399-3038.2005.00309.x

Cited by 85 publications

(70 citation statements)

References 19 publications

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“…Caminiti et al (26) reported four patients with Hashimoto thyroiditis out of 95 patients with chronic urticaria, similar to our results. Brunetti et al (23) found no autoimmune diseases in any of 93 patients with chronic urticaria.…”

Section: Discussionsupporting

confidence: 83%

High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods:The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. Results:The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. Conclusion:The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines. (Turk Pediatri Ars 2016; 51: 198-203)

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Section: Discussionsupporting

confidence: 83%

High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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“…In a study by Caminiti et al (28) conducted in Italy, 9 out of 95 (9.5%) children with chronic urticaria had anti-thyroid autoantibodies, 4 of them with Hashimoto's disease. In contrast, Brunetti et al (20) reported that none of the 93 studied children with chronic urticaria, also recruited from Italy, showed signs of thyroid autoimmunity.…”

Section: Thyroid Autoimmunitymentioning

confidence: 98%

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

Pité¹,

Wedi²,

Borrego³

et al. 2013

Acta Derm Venerol

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Urticaria, defined by the presence of wheals and/or angio-edema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identification of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acute and chronic urticaria as well as physical and other urticaria types in children. Potential underlying causes, namely infections, food and drug hypersensitivity, autoreactivity and autoimmune or other conditions, and eliciting stimuli are considered, with practical recommendations for specific diagnostic approaches. Second-generation antihistamines are the mainstay of pharmacological treatment aimed at relief of symptoms, which require dose adjustment for pae-diatric use. Other therapeutic interventions are also discussed. In addition, unmet needs are highlighted, aiming to promote research into the paediatric population, ultimately aiming at the effective management of childhood urticaria.

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“…There are case reports of an association between chronic urticaria and coeliac disease, which may improve on a gluten-free diet [105,106].…”

Section: Aetiology and Mechanismsmentioning

confidence: 99%

BSACI guideline for the management of chronic urticaria and angioedema

Powell

Leech

Till

et al. 2015

Clin Experimental Allergy

253

221

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SummaryThis guidance for the management of patients with chronic urticaria and angioedema has been prepared by the Standards of Care Committee of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a Web-based system. Their comments and suggestions were carefully considered by the Standards of Care Committee. Where evidence was lacking, a consensus was reached by the experts on the committee. Included in this management guideline are clinical classification, aetiology, diagnosis, investigations, treatment guidance with special sections on children with urticaria and the use of antihistamines in women who are pregnant or breastfeeding. Finally, we have made recommendations for potential areas of future research.

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Chronic urticaria and associated coeliac disease in children: A case–control study

Abstract: The presence of CD in children with CU was significantly more frequent than in controls. GFD resulted in urticaria remission. CD may be regarded in such subjects as a cause of CU.

Cited by 85 publications

References 19 publications

High-dose anti-histamine use and risk factors in children with urticaria

High-dose anti-histamine use and risk factors in children with urticaria

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

BSACI guideline for the management of chronic urticaria and angioedema

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