Chronic urticaria associated with dental infection

Sonoda, Tadashige; Anan, Takashi; Ono, Keiichiro

doi:10.1111/j.1365-2133.2001.04395.x

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Nevertheless, in many cases the relationship is difficult to prove and the mechanism itself remains unclear. 16 Despite the controversy, in some cases dental treatment 17–20 or tonsillectomy result in resolution or reduction of CSU symptoms, 16 which is in line with our unpublished clinical observations. The main studies on dental infection and chronic urticaria are presented in Table 2.…”

Section: Association Between Apr and Csu And Infectious/inflammatory supporting

confidence: 79%

“…It seems that concurrent infectious/inflammatory processes may trigger or aggravate the CSU symptoms by stimulating: (1) autoimmune/autoreactive reactions; (2) the ongoing urticarial inflammation; and (3) mast cells hyperactivity. 16–18 In this regard different immunological and non-immunological factors (e.g. bacteriaemia, toxins, anaphylatoxins) have been proposed.…”

Section: Association Between Apr and Csu And Infectious/inflammatory mentioning

confidence: 99%

“…bacteriaemia, toxins, anaphylatoxins) have been proposed. 16–18 We suggest that CRP and other APR biomarkers may also stimulate severity of the urticarial inflammation; it is known that CRP may directly and via a classic complement-dependent mechanism contribute to the pro-inflammatory state. 3,4…”

Section: Association Between Apr and Csu And Infectious/inflammatory mentioning

confidence: 99%

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Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

Kasperska−Zając

Grzanka

Kowalczyk

et al. 2015

Int J Immunopathol Pharmacol

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Controversy surrounds the role of dental infection/inflammation in the oral cavity in chronic spontaneous urticaria (CSU) and atrial fibrillation (AF), which is mainly due to scarce literature in this area. Therefore, this case report and review of literature illustrate a possible association between the acute-phase response (APR) and clinical conditions, such as CSU and dental infection/inflammation of oral cavity and AF.We describe a 36-year-old man with an 8-year history of difficult-to-treat, uncontrolled CSU, co-existent with dental infection/inflammatory processes of oral cavity and permanent atrial fibrillation (AF). In the presented case, the most likely triggering or aggravating/maintaining factor of the symptoms was the inflammation/dental infection of the oral cavity because of rapid reduction of the urticarial symptoms, drug doses, and serum CRP levels after the dental therapy. Dental treatment may have a beneficial effect on the systemic inflammatory response, reducing/normalizing the circulating levels of APR markers. APR activation appears to worsen CSU course, early identification and treatment of infectious/inflammatory foci in the oral cavity would form the mainstay of supportive therapy for CU probably through reduction of the systemic inflammatory burden. APR associated with infectious/inflammatory foci in the oral cavity could be taken into account as a predisposing agents to AF.

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Section: Association Between Apr and Csu And Infectious/inflammatory supporting

confidence: 79%

Section: Association Between Apr and Csu And Infectious/inflammatory mentioning

confidence: 99%

Section: Association Between Apr and Csu And Infectious/inflammatory mentioning

confidence: 99%

See 1 more Smart Citation

Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

Kasperska−Zając

Grzanka

Kowalczyk

et al. 2015

Int J Immunopathol Pharmacol

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“…In addition, cases have been reported of resolution of urticaria after treatment of dental infections 8, 9 . In one case bacterial cultures from dental lesions grew the gram-negative bacteria Veillonella parvula 10 . It is thought that Lipopolysaccharide from gram negative bacteria induces an inflammatory response characterised by histamine release from mast cells and resulting urticaria 11 .…”

Section: Discussionmentioning

confidence: 99%

Case Report: Resolution of chronic urticaria following treatment of odontogenic infection

2019

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Background: Chronic spontaneous urticaria (CSU) is a condition characterised by the presence of hives with/without angioedema, that affects individuals on more days than not for 6 weeks or more. The role of infection as a potential trigger for CSU is well described, but the current clinical guidelines do not recommend routine screening for underlying infections. Main observations: We report a case of severe prolonged chronic spontaneous urticaria in a 19-year-old, that went into rapid remission following the treatment of dental infection. Conclusions: Clinicians should recognise the potential role that infection can have in causing chronic urticaria. There should be a low threshold to treat infection in such circumstances.

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How does the periapical inflammatory process compromise general health?

Márton¹

2004

Endodontic Topics

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Several lines of evidence support the causative role of oral inflammatory lesions and certain systemic diseases, such as atherosclerosis and cardiovascular diseases, adverse pregnancy outcome and lung diseases. Properly executed epidemiologic studies identified increased odds ratios. Local or metastatic spread of oral microorganisms, local production of microbial or host‐derived soluble regulatory molecules, that may initiate or sustain inflammatory events in remote tissues and organs and the presence of (a) common – extrinsic‐ or intrinsic‐pathological mechanism(s) may result in or contribute to both local and systemic inflammation. A number of cross‐sectional studies addressing a possible association between oral health and systemic diseases have also investigated the presence or the absence of periapical lesions. However, these studies cannot either confirm or refute a role of the periapical inflammatory lesion in the observed associations, since other variables of oral health might have exerted an inestimable influence on general health of the assessed population. The literature, dealing with patients with root canal infections and apical periodontitis as sole oral inflammatory lesions is extremely sparse. Our group has demonstrated that young adults with apical periodontitis exhibit certain biochemical changes, such as elevated levels of C‐reactive protein and an increased whole blood chemiluminescence, which have been shown to elevate the risk for cardiovascular diseases. Future research will be required to determine whether and to what extent may endodontic diseases affect general health.

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Chronic urticaria associated with dental infection

Cited by 5 publications

References 7 publications

Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

Case Report: Resolution of chronic urticaria following treatment of odontogenic infection

How does the periapical inflammatory process compromise general health?

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