Chronic vascular changes in the walls of experimental berry aneurysms of the aortic bifurcation in rabbits.

Stehbens, William E.

doi:10.1161/01.str.12.5.643

Cited by 30 publications

(5 citation statements)

References 11 publications

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“…These results indicate the suitability of this model for studies of thrombogenesis in aneurysms. Though the model differs from those in humans in shape and origin, previous experiments indicate that arterial aneurysms of different types (lateral, fusiform, spherical and berry) in rabbits exhibit similar histological and ultrastructural mural responses to those rn Homo sapiens (25)(26)(27). Despite haemodynamic differences in the models, the major stress remains the pulsatile distension under augmented mural tension.…”

Section: Discussionmentioning

confidence: 93%

Observations on the Development of Mural Thrombi in Chronic Experimental Aneurysms in Sheep

Stehbens

1997

Thromb Haemost

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SummaryObservations were made on mural thrombi in experimental venous pouch aneurysms in sheep. Thrombi associated with mural tears and dissection consisted predominantly of laminated fibrin masking the earlier platelet deposition and infiltrating the wall to some extent. Thrombus growth was associated with platelet masses of Zahn and secondary fibrin deposition. Intervening spaces contained a variable quantity of coagulated plasma, fibrin mesh, leucocytes, disintegrating red cells and platelets rather than red thrombus as often suggested. Periodic deposition of platelet masses with surface rippling, the whorling patterns of laminated fibrin and mechanical disruption of red cells indicated the importance of haemodynamics. Coarse macroscopic lamination of mural thrombi was attributed in part to recurrent dissections between the wall and the mural thrombus and of the thrombus itself. These accounted for growth of thrombus with expansion of the wall and interference with organization of the thrombus. The model has proved suitable for the study of thrombogenesis and thrombus behaviour in aneurysms.

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Section: Discussionmentioning

confidence: 93%

Observations on the Development of Mural Thrombi in Chronic Experimental Aneurysms in Sheep

Stehbens

1997

Thromb Haemost

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“…4 Cartilage tissue is also found within human atherosclerotic plaque, 9 but its frequency has not been systematically assessed. Ectopic tissue occurs in veins as well as arteries 10 and in animal models of atherosclerosis. 11 In mice, vascular ectopic tissue is most often in the form of cartilage.…”

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confidence: 99%

Mesenchymal Stem Cells and the Artery Wall

Abedin

Tintut

Demer

2004

Circulation Research

201

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Abstract-The presence of ectopic tissue in the diseased artery wall is evidence for the presence of multipotential stem cells in the vasculature. Mesenchymal stem cells were first identified in the marrow stroma, and they differentiate along multiple lineages giving rise to cartilage, bone, fat, muscle, and vascular tissue in vitro and in vivo. Transplantation studies show that marrow-derived mesenchymal stem cells appear to enter the circulation and engraft other tissues, including the artery wall, at sites of injury. Recent evidence indicates that mesenchymal stem cells are also present in normal artery wall and microvessels and that they also may enter the circulation, contributing to the population of circulating progenitor cells and engrafting other tissues. Thus, the artery wall is not only a destination but also a source of progenitor cells that have regenerative potential. Although potential artifacts, such as fusion, need to be taken into consideration,

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“…Other researchers previously established a growth pattern of aneurysm in the rabbit and the rat respectively (Stehbens 1981b; Quigley et al, 1988; Kirse et al, 1996). It is generally accepted that most untreated intracranial aneurysms will get larger in human as they did in this model (Allcock & Canham, 1976).…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, there was increased cellularity of perivascular tissues. The inflammatory response was resolved in acute phase, but phlebosclerosis developed in the aneurysms and progressed to severe fibrosis, calcification, ossification, mural thrombosis and lipid deposition resembling human atherosclerosis, with eventual loss of the media, in long term study (Stehbens 1981b). In our study, infiltration of inflammatory cells are composed of neutrophils, lymphocytes and along with mild hemorrhage were found in the junction of the carotid artery and the vein pouch at 1 week.…”

Section: Discussionmentioning

confidence: 99%

“…There is extensive debate within the neurosurgical literature on criteria for surgical candidates, timing of surgery after an acute hemorrhage, and efficacy of different treatment modalities. Many treatment modalities have been available such as direct surgical obliteration of the aneurysm, surgical clamping of the aneurysm, ligation of the feeding vessel proximal to the aneurysm, and endovascular occlusion techniques using balloons or coils (Stehbens 1981b; Krings et al, 2002). Moreover, advanced techniques have been continuously applied and tested in the treatment of aneurysm because established procedures sometimes yield insufficient, complicated or unreliable clinical results (Drake et al, 1984; Heilman et al, 1992; Szikora et al, 1997; Byrne et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits

et al. 2010

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In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after surgery, saccular aneurysms were fashioned on the right common carotid artery in 17 rabbits using a vein pouch technique. Selective angiography of the common carotid artery was performed immediately after surgery, and at 1 week, 4 weeks, and 8 weeks after surgery. Also, histological changes in the aneurysms were observed. In 16 rabbits with established successful experimental aneurysm, no differences were found in diet intake and behavior before and after surgery. The patency of the carotid artery was confirmed by selective angiography. The average size of the aneurysm immediately after surgery was similar to that of 1 week postoperatively in selective angiography, however it increased with time at 4weeks and 8 weeks. Histologically, infiltration of inflammatory cells and hemorrhage were found at the junction of the carotid artery and the vein pouch at 1 week, which disappeared at 4 weeks and 8 weeks. This study suggests experimental saccular aneurysm using the vein pouch technique might form aneurysms similar to that of the human in its properties such as increment of size, and selective angiography might be suitable for assessment of experimental aneurysm. Therefore, this animal model may be suitable for investigating new treatment methodologies for human aneurysms.

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Chronic vascular changes in the walls of experimental berry aneurysms of the aortic bifurcation in rabbits.

Cited by 30 publications

References 11 publications

Observations on the Development of Mural Thrombi in Chronic Experimental Aneurysms in Sheep

Observations on the Development of Mural Thrombi in Chronic Experimental Aneurysms in Sheep

Mesenchymal Stem Cells and the Artery Wall

Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits

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