Chronic venous insufficiency disease

Shami, S.; Sarin, S.; Scurr, J.

doi:10.1055/s-0031-1276036

Cited by 2 publications

(9 citation statements)

References 126 publications

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“…Chronic venous disease (CVD) refers to a broad range of abnormal clinical changes arising from morphological and functional abnormalities of the lower extremity venous system, especially the incompetence of superficial, deep, and perforating veins [1]. "Chronic venous insufficiency" is often mistakenly used as a synonym of CVD, but it should be restricted to the latest stages of the disease [2].…”

Section: Introductionmentioning

confidence: 99%

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Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

Steinbruch

Nunes

Gama

et al. 2020

International Journal of Vascular Medicine

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Background. Phlebotonics have beneficial effects on some symptoms related to chronic venous disease (CVD) of the lower limbs. The most commonly used one is diosmin, available in a pure semisynthetic form or as a micronized purified flavonoid fraction. Patients and Methods. The primary objective of this single-blind, randomized, parallel-group, prospective study was to assess the clinical noninferiority of nonmicronized diosmin 600 mg once daily (D-group) compared to micronized diosmin 900 mg plus hesperidin 100 mg once daily (D/H-group) over a 6-month treatment period. Adult patients with a symptomatic CVD of the lower limbs (C0-C3 grade; 20-60 mm on a 100 mm visual analog scale (VAS)) were included. The primary endpoint was the change (from baseline to last postbaseline value) of the intensity of the lower-limb symptoms on VAS. Results. 114 patients (mean age, 44.4 years; women, 90.4%) were randomized in the per-protocol analysis (D-group, n=57; D/H-group, n=57). Symptoms significantly improved in both groups with adjusted mean VAS changes of -24.9 mm (p<0.0001) in the D-group and -22.8 mm (p<0.0001) in the D/H-group, corresponding to approximately 50% reduction in basal symptom intensity. The difference between groups was -2.1 mm with an upper limit of one-sided 90% confidence interval equal to 1.0 mm for a noninferiority margin set at 20 mm (noninferiority demonstrated). Intent-to-treat analysis confirmed per-protocol analysis. Difficulty in swallowing the tablets (VAS) was significantly lower in the D-group compared to the D/H-group (9.4 mm and 54.7 mm at 6 months, respectively; p<0.0001). The overall safety of both study drugs was good. Conclusion. Nonmicronized diosmin 600 mg was proven to have a noninferior efficacy compared to micronized diosmin 900 mg plus hesperidin 100 mg, associated with greater ease in swallowing the tablet.

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Section: Introductionmentioning

confidence: 99%

“…These symptoms are chronic and progressive and they can alter significantly the quality of life of patients [5]. In industrialized countries, the prevalence of the disease is 2-6.4/1000 with an increased frequency in women and elder individuals [1].…”

Section: Introductionmentioning

confidence: 99%

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

Steinbruch

Nunes

Gama

et al. 2020

International Journal of Vascular Medicine

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“…The prevalence of venous leg ulcer varies from one study to another. Shami S., et al looked at a few Swedish studies, one of them reported prevalence of 6.4/1000 whilst the other reported a prevalence of 3.05/1000 of population (Shami, Sarin, & Scurr, 1997). A study conducted in Ireland revealed a prevalence of 15.2/1000 of population, whilst in North America, chronic venous leg ulcer affect between 500,000 and 2 million individuals per year and over 50% of leg ulcers are considered to be venous leg ulcer (Lazarus, Mahmud, Umair, & Nisa, 2014).…”

Section: Epidemiologymentioning

confidence: 99%

“…A venous leg ulcer occurs on the gaiter area of the lower limb between the ankle joint and knee joint and usually affects the full thickness of the skin. Some studies have defined venous leg ulcers as "a break in the skin below the knee that has not healed within two weeks or a healed venous leg ulcer" (Shami, Sarin, & Scurr, 1997). Others have defined them as a "loss of skin on the leg or foot that takes more than 6 weeks to heal" (Brem, Kirsner, & Falanga, 2004).…”

Section: Chapter One: Introduction and Review Of The Literature 1introductionmentioning

confidence: 99%

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The influence of exercise on ulcer healing in patients with chronic venous insufficiency

Mutlak¹,

Aslam²,

Standfield³

2018

Int Angiol

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Chronic venous insufficiency disease

Cited by 2 publications

References 126 publications

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

The influence of exercise on ulcer healing in patients with chronic venous insufficiency

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