Chronic wound bed preparation using a cleansing solution

Chamanga, Edwin; Hughes, Maria; Hilston, Keith; Sparke, Ann; Jandrisits, Johanna M

doi:10.12968/bjon.2015.24.sup12.s30

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…The antiseptic (OCT/PE) itself as well as the rinse and the gel are well tolerated, as shown by studies (Table 6) and case reports [62,63,64]. As an MD (rinse), it is suitable for wound cleansing [62] and supports biofilm removal [59]. Especially the gel is particularly suitable for antisepsis in patients with burn injuries.…”

Section: Octenidinementioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Octenidinementioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

View full text Add to dashboard Cite

show abstract

“…Efficacy of OCT in promoting complete wound closure or reduction in wound surface over a 4 to 12 week period for VLUs was demonstrated in four small Level 1 7,8 and Level 2 5,6 studies. Evidence from four Level 4 studies [9][10][11][12] conducted in other chronic wound types also established that OCT is associated with positive wound healing outcomes. This evidence supported a Grade B recommendation (a weak recommendation).…”

Section: Clinical Questionmentioning

confidence: 99%

“…• In a small number of case studies at high risk of bias, OCT irrigation (often used in combination with an OCT gel) was associated with a reduction in slough and an increase in granulating tissue and epithelialisation for chronic wounds of different aetiologies [9][10][11][12] (Level 4).…”

Section: Improvement In Wound Healing Outcomesmentioning

confidence: 99%

Evidence Summary: Octenidine for chronic wounds

Haesler

2020

WPR

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“…Biofilms are a precursor to wound infection and they lead to the development of chronic wounds because they typically present in wounds stuck in the inflammatory phase exhibiting high levels of MMPs, which can be a result of chemical imbalance in the wound bed (Phillips et al 2010). As a result of advances in technology and wound care research, irrigation solutions and gels that contain antimicrobial agents, for example, antiseptics such as polyhexanide that are active against Gram-negative and Gram-positive bacteria, have been developed that clean, moisten and decontaminate chronic wounds, thereby reducing the bacterial load in the wound bed (Horrocks 2006, Chamanga et al 2015.…”

Section: Biofilm Removalmentioning

confidence: 99%

Clinical management of non-healing wounds

Chamanga

2018

Nursing Standard

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Chronic wounds are defined as those that have failed to heal after three months. There are various intrinsic and extrinsic factors that may result in the development of chronic wounds, including comorbidities such as diabetes mellitus and venous insufficiency, and lifestyle factors such as obesity, alcohol consumption and smoking. Chronic wounds represent a significant burden on healthcare resources and can have a negative effect on patients' quality of life. This article discusses the assessment and treatment of non-healing chronic wounds. It examines the normal wound-healing process and the management of chronic wounds, including advanced interventions such as electrical stimulation therapy, negative pressure wound therapy and various dressings. This article does not focus on specific wound types; instead, it provides an overview of the factors that can lead to the development of chronic wounds and how these wounds can be managed in clinical practice.

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Chronic wound bed preparation using a cleansing solution

Cited by 11 publications

References 13 publications

Consensus on Wound Antisepsis: Update 2018

Consensus on Wound Antisepsis: Update 2018

Evidence Summary: Octenidine for chronic wounds

Clinical management of non-healing wounds

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