Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels

Zmejkoski, Danica; Zdravković, Nemanja; Trišić, Dijana; Budimir, Milica; Marković, Zoran M.; Kozyrovska, Natalia; Marković, Biljana M. Todorović

doi:10.1016/j.ijbiomac.2021.09.118

Cited by 29 publications

(12 citation statements)

References 47 publications

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“…In this study, the authors observed that the groups treated with hydrogen peroxide and antimicrobial peptides showed eradication of MRSA biofilms in a range that varied from 13% to 75%. In a similar way, Zmejkoski et al [64] evaluated the antibiofilm activity of BC hydrogels enriched with Cs and Cs nanoparticles. This evaluation was carried out with Gram-positive bacteria, such as Streptococcus agalactiae, β-hemolytic Streptococcus, S. aureus, and Enterococcus faecalis, and with Gram-negative bacteria, such as E. coli, K. pneumoniae, P. mirabilis, and P. aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Correia,

de Almeida Campos,

de Queiroz Macêdo

et al. 2024

Biology

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The present study aimed to evaluate the in vitro antibacterial and antibiofilm activity of bacterial cellulose hydrogel produced by Zoogloea sp. (HYDROGEL) containing vancomycin (VAN) against bacterial strains that cause wound infections, such as multidrug-resistant (MDR) Staphylococcus aureus and Staphylococcus epidermidis. Initially, HYDROGEL was obtained from sugar cane molasses, and scanning electron microscopy (SEM) was performed to determine morphological characteristics. Then, VAN was incorporated into HYDROGEL (VAN-HYDROGEL). The antibacterial activity of VAN, HYDROGEL, and VAN-HYDROGEL was assessed using the broth microdilution method to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) against methicillin-sensitive S. aureus (MSSA) ATCC 25923, methicillin-resistant S. aureus (MRSA) ATCC 33591, S. epidermidis INCQS 00016 (ATCC 12228), five clinical isolates of MRSA, and nine clinical isolates of methicillin-resistant S. epidermidis, following the Clinical and Laboratory Standards Institute (CLSI) guidelines. Additionally, the antibacterial activity of VAN, HYDROGEL, and VAN-HYDROGEL was studied using the time-kill assay. Subsequently, the antibiofilm activity of VAN, HYDROGEL, and VAN-HYDROGEL was evaluated using crystal violet and Congo red methods, as well as SEM analysis. VAN and VAN-HYDROGEL showed bacteriostatic and bactericidal activity against MRSA and methicillin-resistant S. epidermidis strains. HYDROGEL did not show any antibacterial activity. Analysis of the time-kill assay indicated that HYDROGEL maintained the antibacterial efficacy of VAN, highlighting its efficiency as a promising carrier. Regarding antibiofilm activity, VAN and HYDROGEL inhibited biofilm formation but did not demonstrate biofilm eradication activity against methicillin-resistant S. aureus and S. epidermidis strains. However, it was observed that the biofilm eradication potential of VAN was enhanced after incorporation into HYDROGEL, a result also proven through images obtained by SEM. From the methods carried out in this study, it was possible to observe that HYDROGEL preserved the antibacterial activity of vancomycin, aside from exhibiting antibiofilm activity and enhancing the antibiofilm effect of VAN. In conclusion, this study demonstrated the potential of HYDROGEL as a candidate and/or vehicle for antibiotics against MDR bacteria that cause wound infections.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Correia,

de Almeida Campos,

de Queiroz Macêdo

et al. 2024

Biology

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“…A study on a bacterial cellulose-chitosan composite hydrogel revealed its significant anti-biofilm potential, reducing active biofilm by 90% and biofilm height by 65%, indicating its potential in treating chronic wounds. 81 Although natural polymers boast several advantages, including biocompatibility, degradability, affordability, and abundant availability, they often present challenges in modification for specific wound treatments. Synthetic polymers can overcome this issue.…”

Section: Hydrogels With Inherent Antibacterial Activitymentioning

confidence: 99%

Multifunctional antibacterial hydrogels for chronic wound management

Hu,

Yu,

Dai

et al. 2024

Biomater. Sci.

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“…Bacterial cellulose (BC)–CS NPs composite hydrogels fabricated by γ-irradiation (20–60 kGy) showed superb antibiofilm properties, reflected in up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height and was characterized by a higher porosity, a higher wound fluid absorption and faster in vitro healing compared to respective composite hydrogels prepared with CS polymer [ 239 ]. LEV-loaded composite scaffolds of PLA electrospun nanofibrous membranes surface-coated by CNFs and/or silk peptide, in which the CNF coating ameliorated the hydrophilicity and silk peptide coating proliferated conjunctival epithelial cells exhibiting effective bactericidal effects; they were able to stimulate structural and functional restoration of conjunctiva after transplant and thus minimize the post-surgery application of antibiotics [ 240 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels

Cited by 29 publications

References 47 publications

Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Multifunctional antibacterial hydrogels for chronic wound management

Advances in Nanostructures for Antimicrobial Therapy

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