Chronic Wound Infection and Antimicrobial Use

Landis, Stephan J.

doi:10.1097/01.asw.0000323578.87700.a5

Cited by 126 publications

(86 citation statements)

References 19 publications

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“…We excluded 29 patients with chronic wounds (54 isolates) because of their unique bacteriological characters and include the remaining 114 patients (201 isolates ) in the analysis. [10], [11] We found polymicrobial growths in 73% of W+ patients, but in only 26% of W– patients, corresponding to an OR of 7.8 (95% CI: 3.2–11.9). (Table 3) The W+ group had less Gram-positive cocci (GPC) infection (43% vs. 80%; OR: 0.2, 95% CI: 0.1–0.5).…”

Section: Resultsmentioning

confidence: 79%

Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Lin

Guo

et al. 2013

PLoS ONE

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ObjectiveThe flood after a typhoon may lead to increase in patients with cellulitis of lower limbs. However, the microbiological features of these cases are rarely reported. We conducted a study of patients with lower extremity cellulitis after a typhoon followed in southern Taiwan to study the risk factors of cellulitis and the bacteriological features of the patients.MethodsWe reviewed all the medical records of cellulitis at emergency departments of two teaching hospitals in southern Taiwan 30 days before and after the landing of Typhoon Morakot and collected data on the demographic and bacteriological characteristics. In addition, we evaluated the relationship between the daily number of patients and the rainfall in the Tainan area.ResultsThe number of cellulitis patients increased from 183 to 344 during the 30-day period after the typhoon. The number peaked in the third and fourth days and lasted for 3 weeks. The proportion of patients with water immersion of the affected limb was higher after the typhoon (6% vs. 37%, odds ratio [OR]: 9.0, 95% Confidence interval [CI]: 4.7–17.2). We found cultures from the infected limbs with immersion had more polymicrobial (73% vs. 26%, OR: 7.8, 95% CI: 3.2–19.2) and Gram-negative bacilli infection (86% vs. 34%, OR: 11.8, 95% CI: 4.1–34.5).ConclusionsFlood arose from Typhoon Morakot caused increases in cellulitis patients, which lasted for 3 weeks. Antibiotic treatment that were effective to both Gram-positive cocci and Gram-negative bacilli are recommended for patients with limbs emerged in the water.

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Section: Resultsmentioning

confidence: 79%

Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Lin

Guo

et al. 2013

PLoS ONE

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“…In normal uninjured skin, the colonization and growth of pathogenic organisms is inhibited by low surface pH, sebum, and fatty acids [1]. The wound healing process has been well characterized histologically; the various stages of wound healing have been widely investigated over the years and the orchestrated events associated with normal healing have been discussed in the Refs.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial photodynamic therapy with RLP068 kills methicillin‐resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion

Vecchio

Huang

Fantetti

et al. 2012

Journal of Biophotonics

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Photodynamic therapy (PDT) is an alternative treatment for infections that can kill drug resistant bacteria without damaging host-tissue. In this study we used bioluminescent methicillin-resistant Staphylococcus aureus, in a mouse skin abrasion model, to investigate the effect of PDT on bacterial inactivation and wound healing. RLP068/Cl, a tetracationic Zn(II)phthalocyanine derivative and toluidine blue (TBO) were used. The light-dose response of PDT to kill bacteria in vivo and the possible recurrence in the days post-treatment were monitored by real-time bioluminescence imaging, and wound healing by digital photography. The results showed PDT with RLP068/Cl (but not TBO) was able to kill bacteria, to inhibit bacterial re-growth after the treatment and to significantly accelerate the wound healing process. Successive bioluminescence images of a representative mouse skin scratch model infected with 108 CFU MRSA.

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“…Skin wounds and the clinical strategies to treat them have significantly changed over the past century: sharp or laser aseptic surgical dissection of the damaged tissues; meticulous wound bed preparation (Panuncialman & Falanga 2007); pharmacological medications to avoid wound bacterial colonization (Khan & Naqvi 2006;White et al 2006;Landis 2008); and biomaterials to replace damaged tissue ( Jones et al 2002;Horch et al 2005;Ehrenreich & Ruszczak 2006;Clark et al 2007) significantly obviated the need for the natural protective cascades involved in wound healing. Apart from function restoration, accepted by our ancestors as appropriate results of wound healing, issues of cosmesis, improved functionality and quality of life are now of great importance during skin-restoration treatment.…”

Section: Future Perspectivesmentioning

confidence: 99%

A review of tissue-engineered skin bioconstructs available for skin reconstruction

Shevchenko

James

2009

J. R. Soc. Interface.

629

469

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Situations where normal autografts cannot be used to replace damaged skin often lead to a greater risk of mortality, prolonged hospital stay and increased expenditure for the National Health Service. There is a substantial need for tissue-engineered skin bioconstructs and research is active in this field. Significant progress has been made over the years in the development and clinical use of bioengineered components of the various skin layers. Off-the-shelf availability of such constructs, or production of sufficient quantities of biological materials to aid rapid wound closure, are often the only means to help patients with major skin loss. The aim of this review is to describe those materials already commercially available for clinical use as well as to give a short insight to those under development. It seeks to provide skin scientists/tissue engineers with the information required to not only develop in vitro models of skin, but to move closer to achieving the ultimate goal of an off-the-shelf, complete full-thickness skin replacement.

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Chronic Wound Infection and Antimicrobial Use

Abstract: After reading this article and taking this test, the reader should be able to: 1. Discuss the etiology of chronic wounds. 2. Describe the agents used for the treatment of chronic wound infections.

Cited by 126 publications

References 19 publications

Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Antimicrobial photodynamic therapy with RLP068 kills methicillin‐resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion

A review of tissue-engineered skin bioconstructs available for skin reconstruction

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