Chronicles of Sponge Biomaterials: The Saga in Biomedicine

Bhatnagar, Ira; Pallela, Ramjee; Bramhachari, Pallaval Veera; Ealla, Kranti Kiran Reddy

doi:10.1007/978-81-322-2794-6_15

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…The vast biological diversity of the marine ecosystem, such as coral reefs and marine sponges is extremely varied as compared to the tropical rainforest (Costello & Chaudhary, 2017;De et al, 2018). Porifera is a group of multicellular primitive metazoans being reported as the source of numerous bioactive secondary metabolites by past research (Bhatnagar et al, 2016). Due to the broad degree of chemical constituents and novel molecular structure, secondary metabolites isolated from marine natural products like marine sponges have been reported to be potential candidates for novel therapeutic drugs for critical diseases (Jimenez, 2018).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Biological Activity of Three Marine Sponges From Theonella and Haliclona Genera Collected From Bidong Island, Terengganu, Malaysia

Jamaludin,

Bakar,

Saidin

2023

MAB

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Marine sponges are primitive sessile animals that are rich sources of biologically active compounds. This paper aimed to assess the in-vitro biological activity of marine sponges from Theonella and Haliclona genera collected from Bidong Island, Terengganu, Malaysia. Biological activities such as antibacterial (discs diffusion assay), antioxidant (DPPH free-radical scavenging assay), and cytotoxicity activity (against cancerous HeLa, MCF-7, HepG-2 cell lines and the normal cell line Vero) were evaluated using MTT cytotoxicity assay. The bioassays were done on methanol extracts at different concentrations. Results indicate that T. swinhoei, and T. cf cupola showed low antibacterial capabilities ranging from 0 to 50 mg/mL and exhibited medium antioxidant activity with the IC50 value of 23.25 ± 1.57 and 18.52 ± 0.86 mg/mL, respectively. Cytotoxicity activities indicate that both species of T. swinhoei and T. cf cupola possesses toxic capabilities to inhibit the proliferation of all cancer cell lines used and demonstrated no significant toxicity for the normal cell line used in this study. Haliclona fascigera showed medium antibacterial activity against all Gram-positive bacteria and low activity against Gram-negative bacteria used. Haliclona fascigera exhibited antioxidant activity with an IC50 value of 1.80 ± 0.08 mg/mL and outcomes of the cytotoxicity activity assay against all cancer cells showed IC50 below 30 µg/mL. Marine sponges evaluated in this study indicate promising bioactive compounds that can be an excellent candidate for drug discovery in prospecting novel antibiotics and anticancer. Despite showing low antibacterial and medium antioxidant activity, species from both Theonella can be further studied in other assays to explore other biological activities whilst marine sponge H. fascigera possesses excellent capabilities in antibacterial, antioxidant, and cytotoxicity activities that can be further studied its chemical compositions for future research.

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Section: Introductionmentioning

confidence: 99%

In Vitro Biological Activity of Three Marine Sponges From Theonella and Haliclona Genera Collected From Bidong Island, Terengganu, Malaysia

Jamaludin,

Bakar,

Saidin

2023

MAB

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“…Marine organisms are a valuable source of active substances that could be used in medicine. Numerous pharmacological and biological properties originating from marine organisms have been established, such as antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antitumor, antimalarial, and antiplatelet activities [1,2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro Cytotoxic Potential of Avarol towards Human Cancer Cell Lines and In Vivo Antitumor Activity in Solid Tumor Models

et al. 2022

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The goal of this study was to determine the activity in vitro and in vivo of avarol, a sesquiterpene hydroquinone originating from the Dysidea avara sponge from the south Adriatic Sea, against different cancer cell lines and two types of mouse carcinoma. To investigate the in vitro cytotoxicity, a human cervix adenocarcinoma cell line (HeLa), human colon adenocarcinoma (LS174), human non-small-cell lung carcinoma (A549), and a normal human fetal lung fibroblast cell line (MRC-5) were used. The in vivo antitumor activity was investigated against two transplantable mouse tumors, the Ehrlich carcinoma (EC) and cervical cancer (CC-5). The effect of avarol on cancer cell survival, which was determined by the microculture tetrazolium test, confirmed a significant in vitro potency of avarol against the investigated cell lines, without selectivity towards MRC-5. The highest cytotoxicity was exhibited against HeLa cancer cells (10.22 ± 0.28 μg/mL). Moreover, potent antitumor activity against two tumor models was determined, as the intraperitoneal administration of avarol at a dose of 50 mg/kg resulted in a significant inhibition of tumor growth in mice. After three administrations of avarol, a 29% inhibition of the EC growth was achieved, while in the case of CC-5, a 36% inhibition of the tumor growth was achieved after the second administration of avarol. Therefore, the results indicate that this marine sesquiterpenoid hydroquinone could be a promising bioactive compound in the development of new anticancer medicine.

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