Chronobiological Therapy for Mood Disorders

Dallaspezia, Sara; Suzuki, Masahiro; Benedetti, Francesco

doi:10.1007/s11920-015-0633-6

Cited by 57 publications

(46 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Delayed sleep phase syndrome (Skene et al, 1999) -Sleep-onset insomnia (Wang-Weigand et al, 2009) -Non-24 h sleep/wake disorder -SW schedule disorder (Roth, 2012) -Smith-Magenis syndrome (Chen et al, 2015) -Delirium (Furuya et al, 2012) -Peptic ulcer disease (Moore & Merki, 1997) -Depression, mania, seasonal affective disorder and seasonal affective bipolar disorder (Dallaspezia et al, 2015;Geoffroy et al, 2015;Klemfuss & Kripke, 1989;Melrose, 2015;Salgado-Delgado et al, 2011) -Nocturnal asthma (Smolensky & D'Alonzo, 1997;) -AI (Chan & Debono, 2010;Debono et al, 2009;Ekman et al, 2014;Johannsson et al, 2009;Quinkler et al, 2015) -Nocturia (Bliwise et al, 2014;Ebell et al, 2014;Miller, 2000;Moon et al, 2004) -Sleep-time non-dipping and rising 24 h BP patterns, that is nocturnal hypertension Hermida et al, 2011aHermida et al, , b, c, 2013cPortaluppi & Smolensky, 2010;Smolensky et al, 2015b).…”

Section: Discussionmentioning

confidence: 99%

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky

Hermida

Reinberg

et al. 2016

Chronobiology International

155

View full text Add to dashboard Cite

Biological processes are organized in time as innate rhythms defined by the period (τ), phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level. The human time structure in its entirety is comprised of ultradian (τ < 20 h), circadian (20 h > τ < 28 h) and infradian (τ > 28 h) bioperiodicities. The circadian time structure (CTS) of human beings, which is more complicated than in lower animals, is orchestrated and staged by a brain central multioscillator system that includes a prominent pacemaker - the suprachiasmatic nuclei of the hypothalamus. Additional pacemaker activities are provided by the pineal hormone melatonin, which circulates during the nighttime, and the left and right cerebral cortices. Under ordinary circumstances this system coordinates the τ and Φ of rhythms driven by subservient peripheral cell, tissue and organ clock networks. Cyclic environmental, feeding and social time cues synchronize the endogenous 24 h clocks and rhythms. Accordingly, processes and functions of the internal environment are integrated in time for maximum biological efficiency, and they are also organized and synchronized in time to the external environment to ensure optimal performance and response to challenge. Artificial light at night (ALAN) exposure can alter the CTS as can night work, which, like rapid transmeridian displacement by air travel, necessitates realignment of the Φ of the multitude of 24 h rhythms. In 2001, Stevens and Rea coined the phrase "circadian disruption" (CD) to label the CTS misalignment induced by ALAN and shift work (SW) as a potential pathologic mechanism of the increased risk for cancer and other medical conditions. Current concerns relating to the effects of ALAN exposure on the CTS motivated us to renew our long-standing interest in the possible role of CD in the etiopathology of common human diseases and patient care. A surprisingly large number of medical conditions involve CD: adrenal insufficiency; nocturia; sleep-time non-dipping and rising blood pressure 24 h patterns (nocturnal hypertension); delayed sleep phase syndrome, non-24 h sleep/wake disorder; recurrent hypersomnia; SW intolerance; delirium; peptic ulcer disease; kidney failure; depression; mania; bipolar disorder; Parkinson's disease; Smith-Magenis syndrome; fatal familial insomnia syndrome; autism spectrum disorder; asthma; byssinosis; cancers; hand, foot and mouth disease; post-operative state; and ICU outcome. Poorly conceived medical interventions, for example nighttime dosing of synthetic corticosteroids and certain β-antagonists and cyclic nocturnal enteral or parenteral nutrition, plus lifestyle habits, including atypical eating times and chronic alcohol consumption, also can be causal of CD. Just as surprisingly are the many proven chronotherapeutic strategies available today to manage the CD of several of these medical conditions. In clinical medicine, CD seems to be a common, yet mostly unrecognized, pathologic mechanism of human disease as are the many effective chronotherapeutic int...

show abstract

Section: Discussionmentioning

confidence: 99%

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky

Hermida

Reinberg

et al. 2016

Chronobiology International

155

View full text Add to dashboard Cite

show abstract

“…Finally, a total sleep deprivation paradigm has also been developed to temporarily alleviate SAD symptoms. Its biological basis is not well understood, although it has been shown to impact neurotransmitter function and rapidly reset behavioral and circadian rhythms (104). Therefore, behavioral and environmental cues employed in these therapies reset and potentiate circadian rhythms, mainly at the behavioral levels, to counter the debilitating depressive tendency.…”

Section: Mood Disorders and Aging As Potential Pathophysiological Tarmentioning

confidence: 99%

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

2017

View full text Add to dashboard Cite

Normal physiological functions require a robust biological timer called the circadian clock. When clocks are dysregulated, misaligned, or dampened, pathological consequences ensue, leading to chronic diseases and accelerated aging. An emerging research area is the development of clock-targeting compounds that may serve as drug candidates to correct dysregulated rhythms and hence mitigate disease symptoms and age-related decline. In this review, we first present a concise view of the circadian oscillator, physiological networks, and regulatory mechanisms of circadian amplitude. Given a close association of circadian amplitude dampening and disease progression, clock-enhancing small molecules (CEMs) are of particular interest as candidate chronotherapeutics. A recent proof-of-principle study illustrated that the natural polymethoxylated flavonoid nobiletin directly targets the circadian oscillator and elicits robust metabolic improvements in mice. We describe mood disorders and aging as potential therapeutic targets of CEMs. Future studies of CEMs will shed important insight into the regulation and disease relevance of circadian clocks.

show abstract

“…Circadian rhythms and sleep researches have been the starting point of the developing of chronobiological therapies of mood disorder [123,124], named chronotherapeutics.…”

Section: Chronotherapeutics In Bipolar Disordermentioning

confidence: 99%

Chronobiology of Bipolar Disorder: Therapeutic Implication

Dallaspezia

Benedetti

2015

Curr Psychiatry Rep

Self Cite

View full text Add to dashboard Cite

Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder arise in part from a malfunction of the circadian system, linking the disease with an abnormal internal timing. Alterations in circadian rhythms and sleep are core elements in the disorders, characterizing both mania and depression and having recently been shown during euthymia. Several human genetic studies have implicated specific genes that make up the genesis of circadian rhythms in the manifestation of mood disorders with polymorphisms in molecular clock genes not only showing an association with the disorder but having also been linked to its phenotypic particularities. Many medications used to treat the disorder, such as antidepressant and mood stabilizers, affect the circadian clock. Finally, circadian rhythms and sleep researches have been the starting point of the developing of chronobiological therapies. These interventions are safe, rapid and effective and they should be considered first-line strategies for bipolar depression.

show abstract

Chronobiological Therapy for Mood Disorders

Cited by 57 publications

References 147 publications

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Chronobiology of Bipolar Disorder: Therapeutic Implication

Contact Info

Product

Resources

About