Chronobiology and Aging

Brock, Mary Anne

doi:10.1111/j.1532-5415.1991.tb05909.x

Cited by 157 publications

(48 citation statements)

References 163 publications

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“…Moreover, evidence suggests that our internal clock may also mediate cognitive functioning (Antoniadis et al 2000;Brock 1991, Stone 1989van Gool 1986;van Someren et al 1993a). In this article, we review recent research on aging and circadian rhythms, with a focus on the senescence-accelerated mouse line.…”

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“…Age-related disruptions of circadian rhythms are a common occurrence in many species, including humans, and are characterized by changes in both behavior and physiology (Brock 1991;Ingram et al 1982;Miles and Dement 1980;van Gool 1986). In elderly humans, rhythm disturbances include fragmented sleep-wake patterns, weak coupling with environmental rhythms, reduced amplitude of daily body temperature rhythms, alterations in the daily rhythm of hormone secretion, high levels of nighttime activity, and reduced daytime cognitive performance (Brock 1991;van Someren et al 1993b;van Someren et al 1996;Weitzman et al 1982).…”

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Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.Key words aging . C-Fos . circadian rhythms . mouse . running wheel . SAMP8 . suprachiasmatic nucleus Cognitive impairments are well-known complaints of the elderly. Despite their obvious clinical importance, many questions remain unanswered. One important issue concerns whether cognitive impairments are due to direct alterations in the cognitive function, or to other difficulties that may in turn result in cognitive deficits. For example, the elderly often report poor night-time sleep quality, daytime sleepiness, lack of energy, and difficulty adjusting to a time shift (increased "jet lag"). Could these effects contribute to cognitive impairments?Although a confluence of factors may lead to poor sleep quality, etc., it is likely that one general culprit is aging of the internal (circadian) clock that regulates these behaviors (Munch et al. 2005;Turek et al. 1995;Weitzman et al. 1982). Moreover, evidence suggests that our internal clock may also mediate cognitive functioning (Antoniadis et al. 2000;Brock 1991, Stone 1989van Gool 1986;van Someren et al. 1993a). In this article, we review recent research on aging and circadian rhythms, with a focus on the senescence-accelerated mouse line. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for the study of age-related changes in cognition.Circadian rhythms are predictable and regularly occurring daily changes in behavior and physiological states. The term circadian, literally meaning "around a day," has its origins in two Latin words: Circa (around) and dies (day). Two defining characteristics AGE (2006) of circadian rhythms are their continued persistence in the absence of external cues in the environment and their ability to be entrained (synchronized) by environmental cues. With respect to the former property, it is the endogenous (self-sustaining) nature of circadian rhythms that engenders an internal clock. With respect to the latter property, the major external cue that serves to synchronize the circadian rhythms of humans and other mammals is light, but almost any periodic event can act as a Zeitgeber ("time-giver").Research on the biological basis of circadian rhythms in humans and other mammals implicates the s...

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Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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“…(Brock, 1991;Copinschi & Van Cauter, 1995;Monk, Buysse, Reynolds Iii, Kupfer, & Houck, 1995;Renfrew, Pettigrew, & Rapoport, 1987). O fato de o idoso acordar mais cedo pode estar relacionado ao aumento da quantidade de sono sincronizado e superfi cial na parte fi nal do sono e, com isso, o indivíduo fi ca mais suscetível aos estímulos ambientais (Dijk, Duffy, & Czeisler, 2000).…”

Section: Fragmentação E Avanço Do Ciclo Vigília/sonounclassified

Ontogênese do sistema de temporização: a construção e as reformas dos ritmos biológicos ao longo da vida humana

Menna‐Barreto

Wey

2007

Psicol. USP

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“…Les effets d'une désynchronisation des rythmes biologiques par rapport aux facteurs environnementaux restent peu connus mais, chez l'homme, les perturbations rythmiques pourraient être à l'origine des altérations physiques, métaboliques et pathologiques observées en situation de dérégulation temporelle artificielle (travail posté, voyages transméridiens), mais aussi lors du vieillissement. En effet, les études conduites chez les mammifères, y compris l'homme, ont démontré, qu'avec l'âge, apparaissaient des perturbations rythmiques caractérisées par des modifications d'amplitude, de phase ou de période selon les paramètres testés, modifications révélatrices d'une possible désynchronisation interne pouvant altérer la survie [1][2][3][4][5]. Ces effets du vieillissement ont surtout été démontrés sur les rythmes journaliers et peu de travaux concernent les rythmes saisonniers présents chez les primates et l'homme.…”

Section: Martine Perret Fabienne Aujardunclassified

“…La fragmentation de ces rythmes s'explique en partie par une augmentation des épisodes de sommeil pendant la journée et de fréquents réveils pendant la nuit [1,10]. À ces phénomènes, s'ajoutent des modifications dans les modalités de resynchronisation lors d'avances ou de retards de phase [11].…”

Section: Vieillissement Et Rythme D'activité Généraleunclassified

Vieillissement et rythmes biologiques chez les primates

Perret

Aujard

2006

Med Sci (Paris)

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Chronobiology and Aging

Cited by 157 publications

References 163 publications

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Ontogênese do sistema de temporização: a construção e as reformas dos ritmos biológicos ao longo da vida humana

Vieillissement et rythmes biologiques chez les primates

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