Chronobiology, excessive daytime sleepiness and depression: Is there a link?

Chellappa, Sarah Laxhmi; Schröder, Carmen; Cajochen, Christian

doi:10.1016/j.sleep.2008.05.010

Cited by 67 publications

(36 citation statements)

References 89 publications

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“…Difficulty getting up in the morning is implicated in individuals with depressive disorders. These data would suggest that considering depression and negative affect in relation to sleep duration and chronotype is necessary (Chellappa et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Ethnic differences in sleep duration and morning–evening type in a population sample

Malone

Patterson

et al. 2015

Chronobiology International

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This cross-sectional population study examined associations of sleep duration and morning–evening type with sociodemographic and cardiometabolic disease in adults participating in the UK Biobank study (N = 439 933). Multivariable Poisson regression models of sleep duration and morning–evening type with a robust error variance were generated to estimate adjusted prevalence ratios and their 95% confidence intervals. All models were adjusted for sex, race, college attendance, employment status and age. Twenty five percent of the sample reported short sleep; 27% were morning, 64% intermediate and 9% evening type. Black ethnicity emerged as most strongly associated with sleep behavior. Short sleep was twice as prevalent, and morning versus intermediate type was 1.4 times more prevalent in Black than White participants. The greater prevalence of short sleep and morning type among Blacks suggests that sleep-based approaches to improving cardiometabolic outcomes may require a more multidimensional approach that encompasses adequate sleep and circadian alignment in this population.

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Section: Discussionmentioning

confidence: 99%

Ethnic differences in sleep duration and morning–evening type in a population sample

Malone

Patterson

et al. 2015

Chronobiology International

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“…Rather, the observed robust intercorrelation is likely due to other causes. Chellappa and colleagues 12 and others 14;35 suggest that disruptions to circadian and homeostatic processes involving basic neurochemistry may account for the interrelationship of depression and sleepiness. This possibility is compelling because it is consistent with our results indicating that rates of elevated depressive symptoms and excessive sleepiness are greatest at the beginning of the agricultural season; the period following migration when circadian and homeostatic processes are most likely to be disrupted from physical relocation and accompanying changes in a myriad of circumstances ranging for daily work habits and routines, to changes in eating behavior and climate, to changes in housing or sleeping accommodation and social connections.…”

Section: Discussionmentioning

confidence: 99%

“…11;12 It is possible that sleepiness and depression are reciprocally related such that the biological, affective and behavioral sequelae of depression compromises restorative sleep and contributes to subsequent sleepiness. 13;14 Sleepiness, in turn, makes individuals more vulnerable to the stresses of everyday life, which may exacerbate depressive symptoms and contribute to the onset of major depressive disorder.…”

Section: Introductionmentioning

confidence: 99%

Depressive Symptoms and Sleepiness Among Latino Farmworkers in Eastern North Carolina

Grzywacz

Chatterjee

Quandt

et al. 2011

Journal of Agromedicine

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Depression and sleepiness are both risk factors for occupational accidents and unintentional injury. Relatively little is known about the experiences of these risk factors in the immigrant Latino farmworker population. This analysis uses prospective panel data from a sample of Latino farmworkers in Eastern North Carolina that was collected at monthly intervals during the 2008 agricultural season to: describe depressive symptoms and daytime sleepiness among immigrant Latino farmworkers across the agricultural season; delineate associations of depressive symptoms with sleepiness across time; and determine whether depressive symptoms precede sleepiness, or if sleepiness precedes depressive symptoms. Results indicated that 45% of farmworkers experienced elevated depressive symptoms across the season, whereas 20% experienced elevated sleepiness. Elevated depressive symptoms were more common among farmworkers living in barracks, and less common among those living in trailers. Sleepiness was more common among women than men. There was no evidence that depressive symptoms contributed to sleepiness, or that sleepiness contributed to depressive symptoms. The pattern of results suggests that a substantial proportion of Latino farmworkers experience levels of depressive symptoms or sleepiness that places them at risk for occupational accident or unintentional injury. The results also suggest that depressive symptoms and sleepiness do not cause each; rather, the association of depressive symptoms with sleepiness hints at the possibility of a common physiologic mechanism such as circadian disruption.

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“…Non-pharmacological (light therapy, sleep deprivation) and pharmacological (lithium, antidepressants, agomelatine, vitamin D) (Parker and Brotchie 2011, and Chapter 23) therapies of affective disorders influence circadian rhythms, which might indicate that they play a role in these disorders (Schulz and Steimer 2009). There are several connections between endogenous depression and circadian rhythms (Chellappa et al 2009;Germain and Kupfer 2008;Lamont et al 2007;McClung 2007), the causes of which are not well understood. Animal models could help here (Kronfeld-Schor and Einat 2012;Workman and Nelson 2011;Ashkenazy et al 2009a, b).…”

Section: Affective Disorders Endogenous Depressionsmentioning

confidence: 99%

How Light Resets Circadian Clocks

2014

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The daily revolutions of the earth around its axis are responsible for day and night and its annual orbit around the sun for the seasons with their fluctuations in day length. Most organisms have adapted to these diurnal and annual cycles. The strategies and mechanisms used are quite delicate and complicated.It came as a surprise that photosynthesis and many other processes are, however, additionally controlled by internal clocks. Thus, photosynthesis fluctuates not only during the daily light-dark cycle (=LD; see the List of Abbreviations and http://www.circadian.org/dictionary.html) but also when the plants are kept under LL and constant temperature (Hennessey and Field 1991). However, the period length (period for short) of this rhythmic event then deviates from exactly 24 h and is therefore called circadian (from Latin circa, about, and dies, day). If in the absence of LD and temperature cycles other 24 h time cues (also called zeitgeber, German for time giver) would control the rhythm, it should show an exact 24 h rhythm. This is not the case, demonstrating the endogenous nature of a clock that is locked to light signals (see Fig. 18.1). Spectrum of RhythmsEndogenous rhythms of organisms are not only tuned to the daily cycle of 24 h. The range of rhythms found in organisms covers ultradian (with periods of several hours to very short ones), circadian, and annual (with periods of about a year) rhythms. Other rhythms such as tidal, 14-day, and monthly ones cope with influences of the moon on the earth, mainly on the water movements of the oceans, and they are therefore found in organisms at the coasts and in the sea. Annual rhythms interact with the day-length changes during the year (see below). There are furthermore rhythms with periods covering several years. The following discussion of a "biological clock" is restricted to circadian rhythms. Even they are often not just composed of one clock type but form a "circadian system" consisting of two or more clocks with different prop- Function of Circadian ClocksThe term "clock" usually implies a time-measuring device or function. For instance, the day length (or night length) can be determined by an organism. Since day length is a function of the time of the year (long days in summer, short days in winter), it can be used to time certain events such as flowering or tuber formation of a plant or breeding of birds and mammals during the most appropriate season. These processes are denoted photoperiodism (see Chap. 19).However, a clock can also be used to set a certain temporal order. For instance, the circadian control of our sleepwake cycle ensures that we rise in the morning and fall asleep in the evening at a preferred time. Food intake and digestion are likewise controlled by this clock and gated to certain times of the day (Silver et al. 2011;Duguay and Cermakian 2009;Forsgren 1935). The circadian clock will time these events also under constant conditions. Furthermore, circadian clocks can serve as alarm clocks.

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Chronobiology, excessive daytime sleepiness and depression: Is there a link?

Cited by 67 publications

References 89 publications

Ethnic differences in sleep duration and morning–evening type in a population sample

Ethnic differences in sleep duration and morning–evening type in a population sample

Depressive Symptoms and Sleepiness Among Latino Farmworkers in Eastern North Carolina

How Light Resets Circadian Clocks

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