Chronobiology of Circulating Blood Cells and Platelets

Haus, Erhard

doi:10.1007/978-3-642-78734-8_37

Cited by 27 publications

(14 citation statements)

References 87 publications

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“…However, reference ranges are a precious tool for evaluating laboratory tests for sports doctors and trainers: studies on seasonal modifications of haematological parameters are then crucial for the rational use of reference values. Seasonal variations reported in the general population on blood cells and particles are very limited and inferior to the observed variations in our samples (Haus, 1992).…”

Section: Discussioncontrasting

confidence: 99%

Haematological parameters in elite rugby players during a competitive season

et al. 2006

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We assessed haematological parameters and possible modifications in elite rugby players throughout a competitive season for increasing the knowledge of physiological characteristics of these sportsmen. Blood samples were collected from the members of the Italian National rugby team at four consecutive training camps during a whole competitive season. Forty-four athletes were recruited for the first camp, 36 for the second, 30 for the third and 32 for the fourth. Due to turnover of the subjects during the season only 13 athletes could be examined at all four camps, and another six in the first three camps. Therefore, we selected the data of these 19 athletes. Iron and transferrin saturation were stable, whilst ferritin increased at the end of the season. The modifications of the soluble transferrin receptor (sTFR) were linked to those of haematocrit: sTFR increased after training and during the competition period when haemoglobin and haematocrit decreased, and decreased at the end of the season. Haemoglobin and haematocrit showed slightly higher levels during the first part of the season and decreased in the second half, when physical demand was high, as demonstrated by biochemical additional tests. Leucocytes and platelets were stable throughout the season. Haematological and iron metabolism parameters in the elite rugby players examined during a whole season fall within physiological range of values. The variability of the parameters during the season is related to training and competition workload. Reticulocytes and sTFR are the most sensitive parameters for studying the iron metabolism of the athletes.

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Section: Discussioncontrasting

confidence: 99%

Haematological parameters in elite rugby players during a competitive season

et al. 2006

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“…This study corroborates earlier results by demonstrating circadian rhythms with comparable acrophases (timing of highest values) in cortisol and hematological parameters in peripheral blood of healthy men (Halberg et al, 1977;Reinberg, 1989;Haus, 1992;Smaaland et al, 1995), as indicated in Fig. 5.…”

Section: Discussionsupporting

confidence: 94%

Circadian Variations in Human Peripheral Blood on Days With and Without Bone Marrow Sampling and Relation to Bone Marrow Cell Proliferation

Abrahamsen¹,

Sothern²,

Sandberg³

et al. 1999

Biological Rhythm Research

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Fifteen bone marrow (BM) and venous blood circadian profiles were obtained from 13 diurnallyactive, healthy men sampled every 4-5 h for 24 h. Peripheral blood (PB) was also sampled in subsets of 5 men either for 24 h immediately preceding the BM procedure or 5-6 months afterwards. Cortisol and white and red cell parameters were determined in PB. BM cell cycle distribution was investigated in parallel by flow cytometry for S-phase DNA of total mononuclear cells and subpopulations of erythroid and myeloid precursor cells. On a group basis, significant circadian rhythms were found in PB variables commonly referred to as "marker" rhythms (cortisol, total white cells [WBC], neutrophils [N], lymphocytes [L]), with acrophases less than 2 h apart between the control day prior to and during BM sampling. Thus, major, but relatively short-lasting physiological stress, like BM aspirations or blood sampling itself, although repeated several times over 24 h, seemed to have minor influence on these rhythms on days of the BM procedure. When comparing the times of highest or lowest values in PB with times of highest or lowest values in BM, several temporal relationships were found. Among other associations, timing of lowest values in WBC, N and L or highest values in cortisol was significantly predictive of highest values in myeloid cells occurring in the following 12 h, whereas highest values in erythroid cells occurred significantly more often in the 12 h interval beginning 4 h after the time of lowest values in WBC, L and N. The stability in the circadian rhythms of the PB variables suggests that information obtained on one day can be used to guide procedures on the next, such as BM myelotoxic chronotherapy or BM harvesting.

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“…Gill and Rastawicka (1986) described elevations in PCV and HB overnight in comparison to light time. Hauss (1994) relates this variation to the influence exerted by alternation between periods of light and darkness on erythropoiesis. After that, Greppi et al (1996) corroborated these results, and they also found a significant effect of biological rhythms in TPP.…”

Section: Circadian Biological Rhythmsmentioning

confidence: 99%