Chronobiology of Mood Disorders

Iasevoli, Felice; Avvisati, Livia; Gilardi, Valentina; Latte, Gianmarco; Prinzivalli, Emiliano; Berardis, Domenico De; Valchera, Alessandro; Fornaro, Michele; Tomasetti, Carmine; Bartolomeis, Andrea de

doi:10.1007/978-81-322-2803-5_20

Cited by 3 publications

(14 citation statements)

References 190 publications

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“…The relationship between chronotypes and several psychiatric disorders has been studied to date and the evening chronotype has been related to a vulnerability to depression and increased alcohol and stimulant drug use. 129 Although sleep/wake cycle alteration, which is considered as a consequence of circadian system disruption, had been the best-known contributor to the pathophysiology of mood disorders for years, today, it is well-recognized that circadian rhythm is entangled with a wide range of molecular and cellular processes that are hypothesized to lead to mood disorders. 130 Accordingly, below we discuss in detail internal and external factors that may play a role in the emergence of mood disorders through various psychophysiological mechanisms within the circadian rhythm processes.…”

Section: Schmentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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Objective Several lines of evidence support a relationship between circadian rhythms disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities.Methods The Medline, Embase, PsycInfo, and Scopus databases were comprehensively and systematically searched and articles published between January 1990 and October 2019 were reviewed. Different combinations of the relevant keywords were polled. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders.Results Although subject characteristics and study designs vary across studies, current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. Impaired HPA-axis function-related glucocorticoid rhythm and disrupted melatonin homeostasis have been prominently demonstrated in schizophrenia and other psychotic disorders, while alterations of molecular expressions of circadian rhythm genes including <i>CLOCK, PER</i>, and <i>CRY</i> have been reported to be involved in the pathogenesis of mood disorders.Conclusion Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.

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Section: Schmentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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“…Chronotype has usually been used to denote sleep habits: morning and evening types. The relationship between chronotypes and several psychiatric disorders has been studied to date and the evening chronotype has been related to a vulnerability to depression and increased alcohol and stimulant drug use (Iasevoli et al, 2016).…”

Section: Mood Disordersmentioning

confidence: 99%

“…Sleep behavior changes, such as difficulties in initiating/maintaining sleep or early morning awakening have been determined in 90% of patients with MDD (Wulff et al, 2010). Sleepwake disruptions are among the criteria for the diagnosis of depression, and comorbid parasomnias are associated with poor treatment outcomes, increased suicidality, and greater relapse risk in depression (Iasevoli et al, 2016;Stubbs et al, 2016;Vadnie and McClung, 2017;Vargas et al, 2019). Sleep architecture alterations including shortened latency of the initial rapid eye movement (REM) sleep, prolonged first REM period, increased total REM time, increased REM density and proportion of REM sleep, and decreased non-REM sleep have been demonstrated in depression (Kupfer and Foster, 1972; 'The application of EEG sleep for the differential diagnosis of affective disorders Kupfer et al, 1984;Rush et al, 1986;Giles et al, 1987;Monteleone and Maj, 2008;Pillai, Kalmbach and Ciesla, 2011).…”

Section: Major Depressive Disordermentioning

confidence: 99%

“…In addition, elevated nocturnal body temperature and daily mean temperature degrees are observed in patients with depression and these higher values normalized with antidepressant treatment (Iasevoli et al, 2016). However, several studies were unable to explain the causal association between body temperature abnormalities and the melatonin increase in depression (Shafii et al, 1996;Hasler et al, 2010).…”

Section: Major Depressive Disordermentioning

confidence: 99%

“…Melatonin activity alteration is also associated with BD due to circadian dysregulations such as changes in the release timing, phase alterations of melatonin secretion, and the sleep-wake cycle (Dallaspezia and Benedetti, 2017). Although findings of melatonin function in patients with BD are inconsistent, circadian system characteristics generally vary depending on the current episode; mania or depression (Iasevoli et al, 2016). Melatonin levels were found higher in the daytime in manic patients than in healthy controls and patients with depressive episode (Nováková et al, 2015).…”

Section: Bipolar Disordermentioning

confidence: 99%

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Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2019

Preprint

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Several lines of evidence support a relationship between circadian disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders. Current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. However, much more work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders, and to develop sound pharmacologic interventions.

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A scenario of unhealthy life cycle: The role of circadian rhythms in health

Chandramouli,

Basavanna,

Ningaiah

2024

Aging Medicine

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Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer. Human pathologies alter circadian clock gene expression, and transgenic rats with clock gene defects progress to cancer and age prematurely. In the growth of age‐linked pathologies and carcinogenesis, cell proliferation and genome integrity play critical roles. The relationship concerning the cell cycle regulation and circadian clock is discussed in this article. The circadian clock controls the behavior and countenance of many main cell cycle and cell cycle check‐point proteins, and cell cycle‐associated proteins, in turn, control the activity and expression of circadian clock proteins. The circadian clock can be reset by DNA disruption, providing a molecular mechanism for mutual control amid the cell cycle and the clock. This circadian clock‐dependent regulation of cell proliferation, composed with other circadian clock‐dependent physiological functions including metabolism control, genotoxic and oxidative stress response, and DNA repair, unlocks new avenues for studying the processes of aging and carcinogenesis.

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Chronobiology of Mood Disorders

Cited by 3 publications

References 190 publications

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

A scenario of unhealthy life cycle: The role of circadian rhythms in health

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