Chronologic Echogenicity Changes and Histologic Correlates in Experimental Blood Clots

Abstract

Sonography using the grayscale median showed chronologic echogenicity changes in clots over a 48-hour period, and the grayscale median correlated with RBC density.

Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis

“…Although human blood clots are composed of variable proportions of fibrin, red and white blood cells in acute stroke 2 , the use of clots generated from platelet-rich plasma ( i.e ., without red blood cells) has also been reported 9 . However, high frequency ultrasound imaging fails to image these platelet-enriched clots (data not shown), because there is no backscattered echo provided by aggregated red blood cells 13 . Consequently, this imaging modality cannot monitor the thrombolytic efficacy of treatments based on a hemolytic effect, as already reported with sonothrombolysis 14 .…”