Chronological change of antibiotic use and antibiotic resistance in Escherichia coli causing urinary tract infections

Shigemura, Katsumi; Yamashita, Masuo; Tanaka, Kazushi; Arakawa, Soichi; Fujisawa, Masato; Adachi, Masayo

doi:10.1007/s10156-011-0241-2

Cited by 36 publications

(40 citation statements)

References 10 publications

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“…1 UTI is generally classified as uncomplicated or complicated according to the presence of urinary tract and/or systematic underlying diseases. 2 Complicated UTI, in particular, sometimes causes or leads to urosepsis, defined as bacteremia associated with urinary tract occlusion by stone or cancer, for instance.…”

Section: Introductionmentioning

confidence: 99%

Shock due to urosepsis: A multicentre study

Yamamichi

Shigemura

Kitagawa

et al. 2017

CUAJ

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Introduction: Urosepsis is a severe infection that can cause shock afterwards. The purpose of this study is to investigate the clinical and bacterial risk factors for shock in those cases with urosepsis caused by urinary tract infection in a multicentre study. Methods: Our study included 77 consecutive urosepsis cases from four hospitals. We examined factors such as patient characteristics, underlying disease, serum white blood cell (WBC) count, platelet count, C-reactive protein (CRP) level at the time of diagnosis of urosepsis, urinary tract occlusion, causative bacteria, and bacterial antibiotic susceptibilities. Statistical analyses were performed to assess the potential risk factors for shock during the clinical course of urosepsis by a multivariate analysis. Results: We had 38 male and 39 female patients aged 25-104 (median 73). Underlying diseases included cancers (n=22, 28.6 %) and diabetes mellitus (n=17, 22.1 %). Positive blood culture was seen in 74 cases; these involved 88 bacterial strains, of which Escherichia coli was the most common (34 strains, 38.6 %). There were 31 cases with shock (40.3 %) and multivariate analyses demonstrated that serum CRP was the only clinical risk factor for shock due to urosepsis. Conclusions: Our study demonstrated that serum CRP was a risk factor for shock during urosepsis in a multicentre analysis. Further prospective studies with a greater number of patients are needed to draw more definitive conclusions.

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Section: Introductionmentioning

confidence: 99%

Shock due to urosepsis: A multicentre study

Yamamichi

Shigemura

Kitagawa

et al. 2017

CUAJ

Self Cite

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“…Patógenos multidroga resistentes, incluindo Staphylococcus aureus resistente à metilcilina, Streptococcus pneumoniae resistente à penicilina e enterococus resistentes à vancomicina 7 , assim como E. coli resistente a fluoroquinolona (FQRE) e produtora de betalactamase de espectro estendido (ESBL) 11 , estão emergindo nas inúmeras instituições de saúde, em todo o mundo. A emergência de cepas resistentes pode ser consequência do uso excessivo de um mesmo agente antimicrobiano 11 .…”

Section: Discussionunclassified

Perfil epidemiológico da infecção nosocomial do trato urinário em hospital universitário de Campina Grande (PB)

et al. 2013

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rESUMo introdução: A infecção do trato urinário (ITU) é a infecção hospitalar mais frequente. objetivo: Este estudo tem como objetivo categorizar e identificar aspectos relacionados à infecção nosocomial do trato urinário (ITUN) no Hospital Universitário Alcides Carneiro (HUAC), em Campina Grande (PB), traçando um perfil dos pacientes com este diagnóstico durante internação de janeiro a julho de 2012 em enfermarias clínicas do hospital (clínica geral, cardiologia, endocrinologia, infectologia e pneumologia). Métodos: Foram analisados prontuários referentes a 436 internamentos. A pesquisa de base quantitativa e qualitativa se caracterizou por um estudo descritivo. As variáveis examinadas incluíram idade, sexo, enfermaria, tempo de internação, sondagem vesical de demora (SVD) e sua duração, exames diagnósticos, evolução para ITUN, drogas utilizadas como terapia empírica inicial, agentes isolados em uroculturas e susceptibilidade antimicrobiana dos patógenos isolados. resultados: Foi identificada a evolução para ITUN em 12,61% das internações, predominando entre pacientes idosos e naqueles com SVD, além da supremacia da Escherichia coli entre os patógenos isolados e sua taxa de resistência às fluoroquinolonas de 50%. Conclusão: As cepas de E. coli isoladas mostraram sensibilidade às cefalosporinas de 2ª e 3ª gerações, amicacina e meropenem. As cepas isoladas de Klebsiella pneumoniae, segundo patógeno mais frequente, foram sensíveis apenas à cefoxitina e ao meropenem. As fluoroquinolonas foram, em nossa pesquisa, as mais prescritas como terapia empírica, o que pode justificar as elevadas taxas de resistência encontradas, tornando, então, seu uso impróprio para tratamento empírico de novos casos.Palavras-chave: infecções urinárias; perfil de saúde; testes de sensibilidade microbiana. ABStrACt introduction:The urinary tract infection (UTI) is the most frequent nosocomial infection. objective: This study aims to categorize and identify issues related to nosocomial urinary tract infection (NUTI) at the Hospital Universitário Alcides Carneiro (HUAC), in Campina Grande (PB), delineating a profile of patients with this diagnosis during hospitalization from January to July of 2012 in the wards hospital (general medicine, cardiology, endocrinology, pulmonology and infectious diseases). Methods: We analyzed 436 medical records pertaining to admissions. The research based on quantitative and qualitative data is characterized by a descriptive study. Variables examined included age, sex, ward, length of hospitalization, indwelling catheter (IC) and duration, diagnostic tests, evolution to NUTI, drugs used as initial empirical therapy, agents isolated from urine culture and antimicrobial susceptibility of isolated pathogens. results: It was identified in the evolution to NUTI 12.61% of hospitalizations, predominantly among elderly patients and those with SVD, beyond the supremacy of Escherichia coli among pathogens and their rate of fluoroquinolone resistance in 50%. Conclusion: The strains of E. coli isolated showed sensitivity ...

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“…Despite aggressive antibiotic therapy, the morbidity and mortality rates associated with P. aeruginosa infection are extremely high due to the intrinsic resistance of P. aeruginosa to many antibiotics and the emergence of multi-drug resistant strains (Koch, 2002;Engel, 2003). P. aeruginosa is a highly versatile pathogen, capable of infecting various human tissues so long as the tissue defences are compromised in some manner (Yamaguchi & Yamada, 1991;Zahm et al, 1991;Tsang et al, 1994;de Bentzmann et al, 1996;Engel, 2003;Daas et al, 2009;Lin et al, 2009;Shigemura et al, 2009). Articular joints, however, are rarely infected with bacterial pathogens, including P. aeruginosa.…”

Section: Introductionmentioning

confidence: 99%