Chronological changes of mumps virus genotypes in Japan between 1999–2013

Aoki, Yoko; Matoba, Yohei; Tanaka, Shizuka; Yahagi, Kazue; Itagaki, Tsutomu; Katsushima, Fumio; Katsushima, Yuriko; Takeda, Makoto; Mizuta, Katsumi

doi:10.3109/23744235.2016.1163730

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…The same sequences were also found in other countries. The sequences in lineage 2 were concentrated in Asian countries, including Japan, China, and Laos from 2000 to 2016 [17,18], but a few of them were also found in the United States in 2006 and 2014–2015. In addition, similar to genotype , the MuV genotype sequences from the different years and areas were intra-crossed within lineages 1 and 2 and did not show obvious differences in time or geography.…”

Section: Resultsmentioning

confidence: 99%

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Mumps Epidemiology and Mumps Virus Genotypes Circulating in Mainland China during 2013-2015

Cui

Zhu

et al. 2017

PLoS ONE

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With the implementation of mumps virus (MuV) vaccination in the expanded program on immunization (EPI) in mainland China since 2008, the incidence of mumps has decreased, and the natural epidemic pattern of mumps has slightly changed during 2013–2015. The two epidemic peaks (April-July and November-December) became less obvious than those observed from 2004 to 2012. Children and adolescents younger than 15, particularly in the five-to-nine-year-old age group, remain the target group and should be the focus of high-quality immunization activities in mainland China. However, it was also found that the incidence and reported cases of mumps decreased in each age group during 2013–2015, particularly in the five-to-nine-year-old and ten-to-fourteen-year-old age groups. The proportion of mumps cases among adults in some provinces also increased. Unlike the changes in the epidemiological characteristics of mumps affected by vaccination, the data of MuV virology surveillance indicated that most of the MuV transmission chains have not yet been effectively interrupted, and MuV remains a natural epidemic pattern in mainland China. In the MuV virology surveillance, 194 MuV strains during 2013–2015 were isolated from 10 of 31 provinces in mainland China. Based on the phylogenetic analysis of the small hydrophobic (SH) gene, both genotype (99.0%) and (1.0%) were identified, and genotype was still the predominant genotype continuously circulating in mainland China. Representative genotype and strains isolated in China from 1995 to 2012 were selected for further analysis. The results indicated that there were multiple transmission chains within genotype , with no obvious geographical or time differences. The high genetic diversity of genotype F strains could be a result of the continuous transmission and evolution of the MuV in mainland China. Genotype was also detected in four provinces in mainland China. Because of the limited epidemiological data, it was uncertain whether the genotype MuV strains found in 2011 and 2013 were imported from other countries. Therefore, combined high-quality epidemiological and virological surveillance is necessary for mumps control; it can also be used to observe the changes in epidemiological characteristics and viral transmission of mumps over time after mumps-containing vaccine (MuCV) implementation and to provide a comprehensive epidemiological and genetic baseline for mumps elimination in mainland China.

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Section: Resultsmentioning

confidence: 99%

“…However, other countries/areas were also found to have the virus, including countries in Asia. Lineage 2 was concentrated in Asia, particularly in Japan [17,18]. The two genotype MuV lineages were both found in China from outbreaks and sporadic cases.…”

Section: Discussionmentioning

confidence: 99%

Mumps Epidemiology and Mumps Virus Genotypes Circulating in Mainland China during 2013-2015

Cui

Zhu

et al. 2017

PLoS ONE

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“…Genotype G was the most frequently detected genotype in Spain during the period of the study, as well as in other western countries and Japan [3,17,27]. A particular variant of this genotype (MuVi/ Sheffield.GBR.1.05/[G]) seemed to be dominant, not only in Spain but also in other countries, according to GenBank records.…”

Section: Discussionmentioning

confidence: 99%

Genomic non-coding regions reveal hidden patterns of mumps virus circulation in Spain, 2005 to 2015

et al. 2018

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BackgroundSince mumps vaccination was introduced in 1981 in Spain, the incidence of the disease has dropped significantly. However, cyclic epidemic waves and outbreaks still occur, despite high vaccination coverage. The World Health Organization (WHO) recommends genotyping to trace the pattern of mumps virus (MuV) circulation. Genotype H was predominant in Spain, but was replaced in 2005 by genotype G which has subsequently remained dominant. Of the small hydrophobic protein gene sequences, 78% are identical and belong to the MuVi/ Sheffield.GBR.1.05/[G]-variant. Our study aimed to investigate whether the circulation of MuV strains in Spain was continuous after the emergence of genotype G in 2005. We obtained 46 samples from Spanish patients infected with MuVi/Sheffield.GBR.1.05/[G] during two epidemic waves and analysed them using new molecular markers based on genomic non-coding regions (NCRs) that discriminate subvariants of this virus strain. Phylogenetic analyses of the nucleoprotein-phosphoprotein and matrix protein-fusion protein NCR indicated strain replacement after a drop in incidence in 2009, which had not been detectable by SH sequencing. Clustering of sequences from patients epidemiologically linked in the same outbreak suggests a potential use for these NCRs in outbreak characterisation. We suggest to consider their use in conjunction with the SH gene in the future WHO recommendations for MuV epidemiological surveillance.

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“…The reason for this is that from 2008–2011, only children aged 2–5 years were the target population of the EPI, while all children above five years are at high risk of mumps. Besides, the cluster 2 strains of genotype G strains first appeared in 2011, and were dominant in 2011 and 2012 [ 32 ]. Thus, the intervention effect was indiscernible in the first three years.…”

Section: Discussionmentioning

confidence: 99%

A Multi-Age-Group Interrupted Time-Series Study for Evaluating the Effectiveness of National Expanded Program on Immunization on Mumps

et al. 2022

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The national Expanded Program on Immunization (EPI) in China has covered vaccines for measles, mumps, and rubella, among children aged 18–24 months since September 2008. However, no previous studies have quantified the effectiveness of the EPI on mumps incidence. There are methodological challenges in assessing the effect of an intervention that targets a subpopulation but finally influences the whole population. In this study, monthly data on mumps incidence were collected in Guangzhou, China, during 2005–2019. We proposed a multi-age-group interrupted time-series design, setting the starting time of exerting effect separately for 14 different age groups. A mixed-effects quasi-Poisson regression was applied to analyze the effectiveness of the EPI on mumps incidence, after controlling for long-term and seasonal trends, and meteorological factors. The model also accounted for the first-order autocorrelation within each age group. Between-age-group correlations were expressed using the contact matrix of age groups. We found that 70,682 mumps cases were reported during 2005–2019, with an annual incidence rate of 37.91 cases per 100,000 population. The effect of EPI strengthened over time, resulting in a decrease in the incidence of mumps by 16.6% (EPI-associated excess risk% = −16.6%, 95% CI: −27.0% to −4.7%) in September 2009 to 40.1% (EPI-associated excess risk% = −40.1%, 95% CI: −46.1% to −33.3%) in September 2019. A reverse U-shape pattern was found in age-specific effect estimates, with the largest reduction of 129 cases per 100,000 population (95% CI: 14 to 1173) in those aged 4–5 years. The EPI is effective in reducing the mumps incidence in Guangzhou. The proposed modeling strategy can be applied for simultaneous assessment of the effectiveness of public health interventions across different age groups, with adequate adjustment for within- and between-group correlations.

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Chronological changes of mumps virus genotypes in Japan between 1999–2013

Abstract: These data demonstrated that the genotype G strains have been endemically perpetuating as the major type over a wide area of Japan since 2001, although the genotype G strains that emerged after 2011 differed from the earlier strains.

Cited by 5 publications

References 19 publications

Mumps Epidemiology and Mumps Virus Genotypes Circulating in Mainland China during 2013-2015

Mumps Epidemiology and Mumps Virus Genotypes Circulating in Mainland China during 2013-2015

Genomic non-coding regions reveal hidden patterns of mumps virus circulation in Spain, 2005 to 2015

A Multi-Age-Group Interrupted Time-Series Study for Evaluating the Effectiveness of National Expanded Program on Immunization on Mumps

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