Chronological changes of perihematomal edema of human intracerebral hematoma

Inaji, Motoki; Tomita, Hiroki; Tone, Osamu; Tamaki, Masashi; Suzuki, Ryuta; Ohno, Katsuhito

doi:10.1007/978-3-7091-0651-8_91

Cited by 79 publications

(87 citation statements)

References 5 publications

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“…This finding is consistent with results obtained from previous observational studies suggesting that perihematomal edema develops within 3 hours after onset of ICH and peaks several, perhaps between 10 and 20, days later. 6,7,14,15 In cross-sectional analyses, there were highly significant correlations between hematoma and perihematomal edema volumes at baseline and at 24 and 72 hours. Longitudinal analyses demonstrated that the baseline variables that were independently associated with absolute growth of edema volumes were lower systolic BP and baseline hematoma volume, and those independently associated with relative growth of edema were history of hypertension, baseline hematoma volume, and earlier time from onset to CT. Of these variables, however, baseline hematoma volume was the only factor that independently predicted both absolute and relative growth of perihematomal edema.…”

Section: Discussionmentioning

confidence: 91%

“…5 Development of perihematomal edema also leads to an elevation in intracranial pressure or hydrocephalus with subsequent clinical deterioration. 6,7 There are several potential mechanisms underlying the formation of cerebral edema after ICH. 4 In a very early phase (first few hours) there is the development of hydrostatic pressure and clot *The INTERACT Investigators are listed in appendix e-1 on the Neurology ® Web site at www.neurology.org.…”

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confidence: 99%

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Significance of perihematomal edema in acute intracerebral hemorrhage

et al. 2009

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Section: Discussionmentioning

confidence: 91%

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confidence: 99%

Significance of perihematomal edema in acute intracerebral hemorrhage

et al. 2009

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“…Hemostasis is eventually achieved by activation of the coagulation cascade along with mechanical tamponade. 34 In rare occasions, surgical specimens are found to have areas of both hemorrhagic and ischemic foci (Fig. 1).…”

Section: Pathogenesis Of Caa and Related Hemorrhagesmentioning

confidence: 99%

Cerebral amyloid angiopathy–associated intracerebral hemorrhage: pathology and management

Mehndiratta¹,

Manjila

Ostergard

et al. 2012

FOC

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Amyloid angiopathy–associated intracerebral hemorrhage (ICH) comprises 12%–15% of lobar ICH in the elderly. This growing population has an increasing incidence of thrombolysis-related hemorrhages, causing the management of hemorrhages associated with cerebral amyloid angiopathy (CAA) to take center stage. A concise reference assimilating the pathology and management of this clinical entity does not exist. Amyloid angiopathy–associated hemorrhages are most often solitary, but the natural history often progresses to include multifocal and recurrent hemorrhages. Compared with other causes of ICH, patients with CAA-associated hemorrhages have a lower mortality rate but an increased risk of recurrence. Unlike hypertensive arteriolar hemorrhages that occur in penetrating subcortical vessels, CAA-associated hemorrhages are superficial in location due to preferential involvement of vessels in the cerebral cortex and meninges. This feature makes CAA-associated hemorrhages easier to access surgically. In this paper, the authors discuss 3 postulates regarding the pathogenesis of amyloid hemorrhages, as well as the established clinicopathological classification of amyloid angiopathy and CAA-associated ICH. Common inheritance patterns of familial CAA with hemorrhagic strokes are discussed along with the role of genetic screening in relatives of patients with CAA. The radiological characteristics of CAA are described with specific attention to CAA-associated microhemorrhages. The detection of these microhemorrhages may have important clinical implications on the administration of anticoagulation and antiplatelet therapy in patients with probable CAA. Poor patient outcome in CAA-associated ICH is associated with dementia, increasing age, hematoma volume and location, initial Glasgow Coma Scale score, and intraventricular extension. The surgical management strategies for amyloid hemorrhages are discussed with a review of published surgical case series and their outcomes with a special attention to postoperative hemorrhage.

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“…Most hematoma enlargement occurs in the first hours following ictus, but this growth can extend for many hours [40,41] . Disruption of the blood-brain barrier implies in the formation of plasma-derived perihematomal edema [42] , which grows rapidly in the first two or three days and reaches full extension about fourteen days after ICH onset [43,44] . Edema evolution can be described in three phases [45] .…”

Section: Pathophysiologymentioning

confidence: 99%

Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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Intracerebral hemorrhage (ICH) is a very complex pathology, with many different not fully elucidated etiologies and prognostics. It is the most severe subtype of stroke, with high mortality and morbidity rates. Unfortunately, despite the numerous promising preclinical assays including neuroprotective, anti-hypertensive, and anti-inflammatory drugs, to this moment only symptomatic treatments are available, motivating the search for new alternatives. In this context, stem cell therapy emerged as a promising tool. However, more than a decade has passed, and there is still much to be learned not only about stem cells, but also about ICH itself, and how these two pieces come together. To date, rats have been the most widely used animal model in this research field, and there is much more to be learned from and about them. In this review, we first summarize ICH epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts. Core tip: In this review, we first summarize intracerebral hemorrhage (ICH) epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.Cordeiro MF, Horn AP. Stem cell therapy in intracerebral hemorrhage rat model. World J Stem Cells 2015; 7(3): 618-629

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Chronological changes of perihematomal edema of human intracerebral hematoma

Cited by 79 publications

References 5 publications

Significance of perihematomal edema in acute intracerebral hemorrhage

Significance of perihematomal edema in acute intracerebral hemorrhage

Cerebral amyloid angiopathy–associated intracerebral hemorrhage: pathology and management

Stem cell therapy in intracerebral hemorrhage rat model

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