Chronological Changes on Magnetic Resonance Images in a Case of Desmoplastic Infantile Ganglioglioma

Abstract

Desmoplastic infantile gangliogliomas (DIGs) are rare tumors during infancy. They often occur as huge cystic tumors in the frontal and parietal lobes, with their solid component being adjacent to the leptomeningeal membrane. This report presents a patient with DIG and intractable epilepsy. Due to hesitation by the patient’s family in allowing surgery, this is the first time that the chronological changes in DIG have been observed on imaging studies. During the follow-up, the tumor changed from a pure solid tumor to a cystic one, which is a typical picture of DIG. Surgical pathology confirmed the diagnosis of DIG. However, for a patient with epilepsy, it is recommended that this condition should be treated immediately with surgery.

Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis

“…8 This suggests our first patient's tumour was solid because it was in the earlier stages of development, with some support for early cyst development from the presence of microscopic cystic change on histology. It may have presented earlier due to the position.…”

Cervico‐medullary desmoplastic infantile ganglioglioma: An unusual case with diffuse leptomeningeal dissemination at diagnosis

“…More generally, in low‐grade gliomas, the incidence of leptomeningeal dissemination is currently reported to be higher than in past (5%); there is speculation as to which, among low‐grade gliomas, most frequently present with leptomeningeal dissemination 16. Second, only three cases of purely solid DIG on neuroimaging have been reported in the literature 5,14,15. As in the case reported by Tseng 14, the MRI changes in our case showed the appearance and changes of a cystic component.…”

Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

“…Histologically, desmoplasia is prominent within dense stroma, with fibroblastic and neuroepithelial elements. Neoplastic cells are limited to the solid nodule and adjacent leptomeninges (5,(10)(11)(12)(13). Neuroepithelial elements vary in proportions of astrocytic and neuronal cells, and as the names suggest, presence of neuronal differentiation distinguishes DIG from DIA.…”