Chronological Improvement in Survival of Patients with Breast Cancer: A Large-Scale, Single-Center Study

Lee, Sae Byul; Sohn, Guiyun; Kim, Ji Sun; Chung, Il Yong; Kim, Hee Jeong; Ko, Beom Seok; Lee, Jong Won; Son, Byung Ho; Kim, Sung‐Bae

doi:10.4048/jbc.2018.21.1.70

Cited by 12 publications

(14 citation statements)

References 25 publications

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“…Anti-HER2 treatments were administered to approximately 60% of our patients with HER2+ cancer. Because it has not been long since anti-HER2 therapies became available in treating node-positive breast cancer in our country [ 31 ], not all HER2+ OBC patients could have received anti-HER2 treatment. Given that HER2-targeted therapies result in favorable outcomes in node-positive HER2-positive breast cancer [ 32 ], such target agent should be incorporated in the management of OBC.…”

Section: Discussionmentioning

confidence: 99%

Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

et al. 2020

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Purpose We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). Conclusions Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.

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Section: Discussionmentioning

confidence: 99%

Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

et al. 2020

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“…The outcomes and survival of women with breast cancer have experienced a significant improvement in the last years comparing to the past decades [27]. This is related to the greater life expectancy and the development of new personalized therapies that improve the quality of life of these patients [28].…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a sexual relations satisfaction scale in patients with breast cancer — “SEXSAT-Q”

Mancha

Muñoz²,

Cruz‐Merino

et al. 2019

Health Qual Life Outcomes

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Purpose Because the currently available questionnaires to evaluate sexual changes on breast cancer women only address the sexual sphere with a few questions our purpose was to develop a questionnaire that assesses changes in sexual dysfunction and satisfaction in women treated for breast cancer. Methods A sample was selected of women aged between 18 and 65 who had had surgery for breast cancer, completed neoadjuvant/adjuvant chemotherapy treatment and could be receiving adjuvant hormonal treatment, with an active sex life at least 3 months before starting treatment. Metastatic disease was excluded. A questionnaire structured in 4 dimensions was developed. The MOS SF-12 and QLQ-BR23 questionnaires were also provided. The following metric properties were evaluated: item analysis; internal consistency; temporal stability; construct validity; concurrent, convergent and divergent validity; and feasibility. Results Three samples were recruited: a pilot sample of 20; a reduction sample of 152; and a validation sample of 148. The presence of 6 dimensions was confirmed: 1) Loss of sex drive; 2) worsening of body image; 3) psychological coping; 4) discomfort during intercourse; 5) satisfaction with sexual relations; and 6) satisfaction with breast reconstruction. Good goodness-of-fit statistics were obtained (χ 2 /df = 1.5, GFI = 0.9, AGFI = 0.84, CFI = 0.959, RMSEA = 0.062). Reliability was good ( α = 0.855 ), as was test–retest stability ( r = 0.838 ). The correlation with the convergent questionnaires proved to be higher than that obtained with generic measurements. Conclusions We were able to develop a short questionnaire (17 items) capable of measuring sexual satisfaction in women with breast cancer with good metric properties. Electronic supplementary material The online version of this article (10.1186/s12955-019-1197-7) contains supplementary material, which is available to authorized users.

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“…According to the statistics of the Korea Central Cancer Registry, breast cancer was the most common cancer in women reported in Korea in 2016 [ 2 ]. Early detection and development of surgical treatment and systemic therapy have led to an improvement in the prognosis of breast cancer [ 3 ]. Over time, there has been an increase in breast cancer survival, and efforts to improve the quality of life of these patients have been emphasized [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Poloxamer-Based Thermo-Sensitive Sol-Gel Agent on Upper Limb Dysfunction after Axillary Lymph Node Dissection: A Double-Blind Randomized Clinical Trial

et al. 2021

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Purpose Restricted shoulder motion is a major morbidity associated with a lower quality of life and disability after axillary lymph node dissection (ALND) in patients with breast cancer. This study sought to evaluate the antiadhesive effect of a poloxamer-based thermosensitive sol-gel (PTAS) agent after ALND. Methods We designed a double-blind, multicenter randomized controlled study to evaluate the clinical efficacy and safety of PTAS in reducing upper-limb dysfunction after ALND. The primary outcome was the change in the range of motion (ROM) of the shoulder before surgery and 4 weeks after ALND (early postoperative period). Secondary outcomes were shoulder ROM at six months, axillary web syndrome, and lymphedema (late postoperative period). Results A total of 170 patients with planned ALND were randomly assigned to one of 2 groups (poloxamer and control) and 15 patients were excluded. In the poloxamer group (n = 76), PTAS was applied to the surface of the operative field after ALND. ALND was performed without the use of poloxamer in the control group (n = 79). Relative to the control group, the poloxamer group had significantly lower early postoperative restrictions in total shoulder ROM at four weeks (−30.04 ± 27.76 vs. −42.59 ± 36.79; p = 0.0236). In particular, the poloxamer group showed greater reductions in horizontal abduction at four weeks (−3.92 ± 9.80 vs. −10.25 ± 15.42; p = 0.0050). The ROM of the shoulder at 24 weeks, axillary web syndrome, and lymphedema were not significantly different between the two groups. No adverse effects were observed in either group. Conclusion We suggest that poloxamer might improve the early postoperative shoulder ROM in patients with breast cancer who have undergone ALND. Trial Registration ClinicalTrials.gov Identifier: NCT02967146

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Chronological Improvement in Survival of Patients with Breast Cancer: A Large-Scale, Single-Center Study

Cited by 12 publications

References 25 publications

Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

Development and validation of a sexual relations satisfaction scale in patients with breast cancer — “SEXSAT-Q”

Effect of Poloxamer-Based Thermo-Sensitive Sol-Gel Agent on Upper Limb Dysfunction after Axillary Lymph Node Dissection: A Double-Blind Randomized Clinical Trial

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