Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems

Battu, Sowjanya; Yalavarthi, Prasanna Raju; Gopireddy, Venkata Subba Reddy; Vattikuti, Uma Maheshwara Rao; Devi, Jyothshna; Vadlamudi, Harini Chowdary

doi:10.2174/1872211312666171213113127

Cited by 1 publication

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“…To begin constructing the pulsatile drug delivery system, an in-depth understanding of the disease's physiology is necessary [27]. In a condition where the body's circadian rhythms are crucial, the drugs' pharmacokinetics and/or pharmacodynamics fluctuate over a day [28,29]. A list of diseases exhibiting this kind of chronological pattern can be found in [table 1].…”

Section: Disadvantagesmentioning

confidence: 99%

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Pulsatile Drug Delivery Systems the Novel Approach

BODKE,

TEKADE,

BADEKAR

et al. 2024

Int J Pharm Pharm Sci

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Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.

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Section: Disadvantagesmentioning

confidence: 99%

“…Budesonide (Microparticles) [63,64], Fluticasone furoate (Nasal spray) [64] Asthma Asthma is a long-term lung illness that affects people of all ages. It is caused by inflammation and muscle stiffness around the airways, making breathing difficult.…”

Section: -Fluorouracil (Pulsincap) [59]mentioning

confidence: 99%