Chronopharmacological studies of ketamine in normal and NMDA Ε1 receptor knockout mice †

Sato, Yuki; Kobayashi, Eiji; Hakamata, Yoji; Kobahashi, M.; Wainai, Tasuku; Murayama, Takanori; Mishina, Masayoshi; Seo, Norimasa

doi:10.1093/bja/aeh144

Cited by 51 publications

(38 citation statements)

References 35 publications

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“…Our results agree with those of preceding studies showing that the anesthetic effects of other agents, such as althesin, pentobarbital, ketamine, and halothane, are higher during the natural sleep period (Bruguerolle et al, 1977;Giedt et al, 1978;Nelson and Halberg, 1973). Recent experiments in rodents also showed that the duration of Ketamine effects varies over 24 h (Rebuelto et al, 2004;Sato et al, 2004). We did not measure blood levels of propofol in this study.…”

Section: Chronopharmacology Of Propofol Anesthesiasupporting

confidence: 92%

“…No significant time-dependent differences in plasma concentrations of ketamine between activity and resting periods in mice were observed, in contrast to the time-of-day differences in the duration of ketamine anesthesia. In that study, the results observed using NMDA receptor epsilon1 subunit KO mice (ie absence of daily variations in ketamine effects, ketamine constituting an NMDA antagonist) suggest rather that daily variations in anesthetic effect depend on circadian differences in the sensitivity of the central nervous system to the drug (Sato et al, 2004). Propofol is supposed to act mainly via GABA A receptors to induce anesthesia (Trapani et al, 2000).…”

Section: Chronopharmacology Of Propofol Anesthesiamentioning

confidence: 87%

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Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Challet

Gourmelen

Pévet

et al. 2006

Neuropsychopharmacol

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Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (72 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant resetting effect at other times of the day. Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock. Neuropsychopharmacology (2007) 32, 728-735.

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Section: Chronopharmacology Of Propofol Anesthesiasupporting

confidence: 92%

Section: Chronopharmacology Of Propofol Anesthesiamentioning

confidence: 87%

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Challet

Gourmelen

Pévet

et al. 2006

Neuropsychopharmacol

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“…For example, in rats, the duration of sleep that is caused by anaesthetic agents such as pentobarbital, hexobarbital and others, is dependent on the state of the circadian system. Potentiated hypnotic effects are likely the result of changes in the daytime sensitivity of the central nervous system to ketamine in the active phase of the circadian cycle (Sato et al, 2004). In mice that were active between 19:00 h and 01:00 h, and less active between 07:00 h and 19:00 h, it was found that after the administration of ketamine and pentobarbital at 22:00 h (active phase), significantly more episodes of the loss of righting reflex occurred compared with the administration at 10:00 h (inactive phase) (Sato et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Autonomic Nervous System under Ketamine/xylazine and Pentobarbital Anaesthesia in a Wistar Rat Model: A Chronobiological View

2013

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Key words: Anaesthesia -Interval -Ketamine/xylazine -Pentobarbital -RatHeart rate variability Abstract:The aim of the present study was to determine the effect of ketamine/ xylazine and pentobarbital anaesthesia on heart rate variability as a marker of autonomic nervous system activity. The experiments were performed in ketamine/ xylazine (10 mg/kg/15 mg/kg) and pentobarbital (40 mg/kg, i.p.) anaesthetized female Wistar rats, after adaptation to a light-dark cycle of 12 hours light: 12 hours dark. Heart rate variability parameters (RR interval, power VLF (very low frequency), power LF (low frequency), power HF (high frequency) and relative powers) were evaluated during spontaneous breathing as a function of the light-dark cycle (LD cycle). Significant LD differences were found in the duration of RR intervals in ketamine/xylazine compared with pentobarbital-anaesthetized rats. Correlation analysis revealed moderate dependency between the RR interval duration and HF and LF power parameters in ketamine/xylazine anaesthesia in both light and dark parts of the cycle. In pentobarbital-anaesthetized rats, correlation analysis demonstrated a moderate dependence between RR interval duration and HF and VLF power parameters, but only in the dark part of the LD cycle. Ketamine/xylazine anaesthesia increased parasympathetic activity, and suppressed sympathetic and baroreceptor activity independently of the light-dark cycle. LD differences in RR interval duration were not eliminated. Pentobarbital anaesthesia increased parasympathetic activity, decreased sympathetic and baroreceptor activity, and eliminated LD differences in RR interval duration.

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“…Também está demonstrada a menor latência da bupivacaína e da lidocaína na analgesia da raquianestesia. Embora o impacto do tempo sobre a ação e o efeito dos anestésicos, analgésicos, sedativos e adjuvantes esteja cientificamente demonstrado, ainda não é corrente na pesquisa anestesiológica o estudo cronobiológico e/ou cronofarmacológico no ato anestésico [86][87][88][89][90][91][92][93][94][95] .…”

Section: Tempounclassified

“…The reduced latency of bupivacaine and lidocaine in epidural analgesia has also been demonstrated. Although the impact of time on the action and effect of anesthetics, analgesics, sedatives, and adjuvants has been demonstrated scientifically, it is not frequent the chronobiological and/or chronopharmacological study during anesthesia in anesthetic research [86][87][88][89][90][91][92][93][94][95] . strawberry pie, and even chicken soup [96][97][98][99] .…”

Section: Timementioning

confidence: 99%

Analgesia adjuvante e alternativa

Vale¹

2006

Rev. Bras. Anestesiol.

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Chronopharmacological studies of ketamine in normal and NMDA Ε1 receptor knockout mice †

Cited by 51 publications

References 35 publications

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Autonomic Nervous System under Ketamine/xylazine and Pentobarbital Anaesthesia in a Wistar Rat Model: A Chronobiological View

Analgesia adjuvante e alternativa

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