Chronopharmacology of Morphine in Mice

Cui, Yu Xin; Sugimoto, Koh‐ichi; Araki, Nobutaka; Sudoh, Toshiaki; Fujimura, Akio

doi:10.1081/cbi-200062397

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…1). Number of the writhing reaction was peaked at just before the active phase (dusk) and reduced during the active phase (dark period) under ad libitum feeding condition as previously reported [4,7,[18][19][20]. The number of writhes, however, was peaked from late night to morning and reduced from dusk to early night under the daytime restricted feeding condition.…”

Section: Resultssupporting

confidence: 64%

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CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice

Oishi

Ohkura²,

Séi³

et al. 2007

NeuroReport

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Kaolin-induced writhing reaction is a simple and convenient model of bradykinin-induced pain for assessment of analgesic actions. In this study, we demonstrated that the number of kaolin-induced writhing reaction was fluctuated in a circadian manner that peaked at the end of the resting period (dusk) and reduced during the active (dark) period in mice. Circadian rhythm of the writhing intensity was completely phase-shifted by a time-imposed restricted feeding. On the other hand, 24 h of food deprivation did not affect the writhing intensity, suggesting that the endogenous clock that can be entrained to the scheduled feeding is responsible to the circadian intensity of the writhing reaction. Day/night fluctuation of the writhing intensity was completely abolished and the writhing reaction was significantly reduced in the circadian clock deficient Clock-mutant mice, although the kaolin-induced bradykinin production and blood pressure suppression were not affected in these mutant mice. Our present study suggested that the circadian variation of the pain sensitivity is governed by the food-entrainable endogenous clock and by the circadian clock molecules in mammals.

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Section: Resultssupporting

confidence: 64%

“…In this study, we at first showed the circadian changes in the number of kaolin-induced writhing reaction in mice under a light-dark condition as previously reported [4,7,[18][19][20]. The intensity of writhing reaction is peaked at the end of the resting period (dusk) and reduced during the active (dark) period.…”

Section: Discussionmentioning

confidence: 79%

CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice

Oishi

Ohkura²,

Séi³

et al. 2007

NeuroReport

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“…In contrast, nocturnally active rats as well as night shift workers were apparently little affected (Brelis, 1984). Circadian rhythmicity in host tolerance to, and toxicity of, chemical agents was first documented in laboratory experiments almost 50 yrs ago; more recent examples include ketamine/midazolam (Rebuelto et al, 2005), nedaplatin (Cui et al, 2004), irinotecan (Filipski et al, 2004), alcohol (Danel and Touitou, 2004), loratadine (Dridi et al, 2005), and morphine (Cui et al, 2005). The hypothesis of the MIC chronotoxic effect, however, has never been tested.…”

Section: Introductionmentioning

confidence: 97%

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Sani¹,

Gadacha²,

Boughattas

et al. 2006

Chronobiology International

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Thiosulfate sulfurtransferase (TST) is an important 'enzyme of protection,' that accelerates the detoxification of cyanide, converting it into thiocyanate. The TST physiological rhythm was investigated at wks 2, 4, and 8 of post-natal development (PND) in the mouse. The results revealed a statistically significant gender-related difference, with the highest activity in females, at all the documented PND stages. In the second week of PND (pre-weaning time), the circadian rhythm of the enzyme activity was associated with ultradian components. The prominent circadian rhythm (tau=24 h) peaked at the beginning of the light span, more precisely approximately 3 HALO (Hours After Light Onset). A week after weaning (wk 4 of PND), an impairment of the rhythm, with the peak shifted toward the second half of photophase, was recorded. Four to 6 wks later, about wk 8 of PND, the circadian rhythm pattern was stabilized, with its peak then located at the beginning of the dark span (13 HALO). The obtained results showed a 12 h phase-shift of the circadian TST peak time during PND, suggesting that the rhythm stabilization is age-dependent.

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“…There are several indications that time of day influences morphine's effect in both humans and animal models [3][4][5][6][7][8][9][10][11][12][13][14]. However, the physiological mechanisms that underlie these variations in morphineinduced analgesia are unknown.…”

Section: Introductionmentioning

confidence: 99%

Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

Kervezee

Hartman

Berg

et al. 2017

European Journal of Pharmaceutical Sciences

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The pharmacokinetics and pharmacodynamics of drugs are influenced by daily fluctuations in physiological processes. The aim of this study was to determine the effect of dosing time on the pharmacokinetics and brain distribution of morphine. To this end, 4mg/kg morphine was administered intravenously to Wistar rats that were either pre-treated with vehicle or tariquidar and probenecid to inhibit processes involved in the active transport of morphine. Non-linear mixed effects modelling was used to describe the concentration-time profiles of morphine and its metabolite M3G in plasma and brain tissue. We found that the concentrations of morphine in the brain and of M3G in plasma depended on the time of day, which could be quantified by a 24-hour rhythm in the efflux of morphine from brain tissue back into the circulation, with the lowest efflux during the two light-dark phase transitions with a difference between peak and trough of 20%. The active processes involved in the clearance of morphine and its metabolite M3G from plasma also showed 24-hour variation with the highest value in the middle of the dark phase being 54% higher than the lowest value at the start of the light phase. Hence, time of day presents a considerable source of variation in the pharmacokinetics of morphine, which could be used to optimize the dosing strategy of morphine.

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Chronopharmacology of Morphine in Mice

Cited by 17 publications

References 14 publications

CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice

CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

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